Diagnosis of gastric adenocarcinoma using a scoring system ...

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Jul 22, 1994 - JAW-TOWN LIN, WEN-CHUNG LEE, MING-SHIANG Wu, JIN-TOWN WANG, TEH-HONG WANG, and CHIEN-JEN CHEN. Department of ...
Journalof

GastroenterologyI

J Gastroenterol 1995; 30:156-161

9 Springer-Verlag 1995

Diagnosis of gastric adenocarcinoma using a scoring system: Combined assay of serological markers of Helicobacter pylori infection, pepsinogen I and gastrin JAW-TOWN LIN, WEN-CHUNGLEE, MING-SHIANGWu, JIN-TOWN WANG,TEH-HONGWANG,and CHIEN-JEN CHEN Department of Internal Medicine, Collegeof Medicine and Institute of PublicHealth, Collegeof PublicHealth, National Taiwan University, Taipei, Taiwan

Abstract: This study was carried out to develop a scoring system for the diagnosis of gastric adenocarcinoma (GAC). A total of 686 subjects, 150 patients with GAC, 182 with gastric ulcer, 127 with duodenal ulcer, and 227 subjects with negative findings, were enrolled. Analysis of the likelihood ratio (LR) showed that patients with advanced age, ulcer in the stomach, low serum levels of pepsinogen I (PGI), low PGI • gastrin values, and low PGI/gastrin ratio were likely to have GAC. Of these indicators, the serum PGI level had the greatest weight, with a LR of 7.59 for the group with a level