antipsychotic (AP), and mood stabilizer (MS) use, in aggregate and individually, were compared in BDI versus BDII patients, either in. Milan and Stanford pooled ...
26th European Congress of Psychiatry / European Psychiatry 48S (2018) S72–S140
OR0014
Differential patterns of psychotropic prescription in bipolar I and Ii disorder among European and American patients not in a syndromal episode C. Arici1* , B. Dell’Osso1 , L. Cremaschi1 , F. Hooshmand2 , L. Oldani1 , M.C. Palazzo1 , B. Benatti1 , B. Grancini1 , M. Vismara1 , V. De Carlo1 , S. Miller2 , T.A. Ketter2 , A.C. Altamura1 1 Fondazione IRCCS Ca’Granda Ospedale Maggiore Policlinico University of Milan, Department of Psychiatry, Milan, Italy; 2 Stanford University School of Medicine, Department of Psychiatry and Behavioral Sciences, Stanford, CA, USA * Corresponding author Introduction.– Limited evidence is available about differential pharmacological management of Bipolar Disorder (BD) I vs II. Indeed, pharmacological treatment choices have been usually based on specific clinical dimensions rather than diagnostic subtypes. Objectives.– The present study was aimed to assess different patterns of psychotropic prescription in European and American bipolar patients, not in a syndromal episode, referred to Milan and Stanford University BD Clinics, respectively, and stratified by bipolar subtype. Methods.– Prevalence and clinical correlates of antidepressant (AD), antipsychotic (AP), and mood stabilizer (MS) use, in aggregate and individually, were compared in BDI versus BDII patients, either in Milan and Stanford pooled sample and in Milan vs Stanford samples. Results.– BDI (n = 424) vs BDII (n = 239) patients (Milan and Stanford pooled) significantly more often took APs (69.8% vs 44.8%), MSs (68.6% vs 57.7%), and valproate (40.1% % vs 17.5%), but significantly less often ADs (23.1% vs 55.6%) and lamotrigine (9.9% vs 25.2%). Milan (n = 380) compared with Stanford sample (n = 283) significantly more often took APs (BDI and BDII), ADs (BDII), and valproate (BDII), but significantly less frequently MSs (BDI) and lamotrigine (BDI). Conclusions.– The present study highlights specific differences in BD psychotropic prescription patterns, either considering the geographic areas of recruitment and the diagnostic subgroups. Investigation on pharmacotherapy in relation to bipolar subtype and treatment location is warranted in order to enhance clinical management of patients suffering from different bipolar disorders. Disclosure of interest.– The authors have not supplied a conflict of interest statement.
OR0015
Prague bipolar offspring study: Psychopathological, neuropsychological and QEEG correlates M. Brunovsky1,2* , J. Horacek1,2 , M. Viktorinova1,2 , T. Novak2,3 , A. Sebela3 , M. Goetz4 1 National Institute of Mental Health, Applied Brain ElectroPhysiology, Klecany, Czech Republic; 2 Third Faculty of Medicine, Charles University, Department of Psychiatry, Prague, Czech Republic; 3 National Institute of Mental Health, Inpatient Ward 2: Mood Disorders, Klecany, Czech Republic; 4 Second Faculty of Medicine, Motol University Hospital, Charles University, Department of Paediatric Psychiatry, Prague, Czech Republic * Corresponding author
S77
Introduction.– Studies in adults show that approximately 30–60% of individuals diagnosed with bipolar disorder (BD) retrospectively report the onset of their illness in childhood. Objectives.– To determine psychopathology, cognitive functions and identify early markers in EEG cortical sources, cortical connectivity and event-related potentials (ERPs) in a sample of offspring of parents with BD (BDO) compared to healthy controls (HC). Methods.– Lifetime and current presence of DSM-5 diagnoses were assessed in 43 BDO (mean age: 12.5 ± 3.1 years) and 43 HC matched for sex, age and IQ. ERP(P300,N2/P3) and EEG were available for 34 subjects in both subgroups. The comparison of the distribution of current densities and functional connectivity was done by independent t-tests of log-transformed s/eLORETA values. Results.– Thirty-seven BDO (86%) and 18 controls (42%) met criteria for at least one lifetime psychiatric diagnosis (adjusted OR = 7.2). While the groups did not differ in ERP and extended neuropsychological testing, significant differences were observed in alpha-1, beta-3 and gamma sources in resting EEG: BDO showed decreased alpha-1, beta-3 and gamma sources in temporal gyri and cingulate as well as decreased connectivity in alpha-1 between bilateral temporal areas and an increase within the right fronto-temporal areas in gamma band. Conclusions.– We found a higher rate of lifetime anxiety and mood disorders in children at confirmed familial risk for BD. The differences in activity during resting EEG could represent trait vulnerability marker for later onset of BD and suggest an altered functioning of cortical networks in high-risk population. Disclosure of interest.– The authors have not supplied a conflict of interest statement. Acknowledgement.– Supported by projetcs AZV-MZCR 15-33250A, 17-32478A and PROGRES Q35.
OR0016
Relationship between childhood adversity and impulsivity in major depression and bipolar types I and Ii A. Do, T. Cassis* , M. Saint Laurent, P. Cervantes, N. Low Institute of research, McGill University Health Center, Psychiatry, Montreal, Canada * Corresponding author Background.– Impulsivity in mood disorders has been associated with increased risk for substance misuse and suicide. Childhood adversity is also common risk factor for impulsivity in mood disorders. To date, there is data lacking related to the specific differences and predictors (including childhood adversity) of impulsivity among the mood disorder types. Aims.– To examine the prevalence of impulsivity in patients with major depression (MDD), bipolar type I (BPI) or bipolar type II (BPII). To examine childhood adversity as a modifier of the association between impulsivity and mood disorder type. Methods.– Participants were recruited from the McGill University Health Center in Montreal, Quebec. Mood diagnoses were determined using the Structured Clinical Interview for DSM-IV Axis I Disorders (SCID). Barrett’s Impulsivity Scale (BIS) was impulsivity in the attentional, motor and non-planning domains. Childhood adversity was assessed using the Childhood Experiences of Care and Abuse Questionnaire (CECA-Q). ANOVA and kruskal-wallis tests and linear regression models were conducted. Results.– Impulsivity in the attentional and non-planning domains was greater in BPII than MDD and BPI. However, when childhood adversity is examined, the association between mood disorder type was explained by maternal psychological abuse which is associated with greater impulsivity in the attentional domain. Similarly, for impulsivity in the non-planning domain, the association between
