Disruption of the Axonal Trafficking of Tyrosine

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Research Article: New Research | Neuronal Excitability

Disruption of the Axonal Trafficking of Tyrosine Hydroxylase mRNA Impairs Catecholamine Biosynthesis in the Axons of Sympathetic Neurons Axonal TH and catecholamine synthesis Aschrafi Armaz1, Gioio E Anthony1, Dong Lijin2 and Barry B. Kaplan1 1

Laboratory of Molecular Biology Division of Intramural Research Programs, National Institute of Mental Health National Institutes of Health, Bethesda, MD 20892, USA 2

Genetic Engineering Core, National Eye Institute National Institutes of Health, Bethesda, MD 20892, USA

DOI: 10.1523/ENEURO.0385-16.2017 Received: 28 December 2016 Revised: 2 May 2017 Accepted: 17 May 2017 Published: 26 May 2017

Author contributions: A.A., A.E.G., L.D., and B.B.K. designed research; A.A., A.E.G., L.D., and B.B.K. analyzed data; A.A. and B.B.K. wrote the paper; A.E.G. contributed unpublished reagents/analytic tools. Funding: HHS | NIH | National Institute of Mental Health (NIMH) 100000025 ZIA-MH002768

The authors declare no competing financial interests. This work was supported by the Division of Intramural Research Programs of the National Institute of Mental Health (ZIA- MH002768). Correspondence should be addressed to Barry B. Kaplan, Laboratory of Molecular Biology, Division of Intramural Research Programs, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA. E-mai: [email protected] Cite as: eNeuro 2017; 10.1523/ENEURO.0385-16.2017 Alerts: Sign up at eneuro.org/alerts to receive customized email alerts when the fully formatted version of this article is published.

Accepted manuscripts are peer-reviewed but have not been through the copyediting, formatting, or proofreading process. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed. Copyright © 2017 the authors





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