Dissolvable films of silk fibroin for ultrathin conformal ...

Dissolvable films of silk fibroin for ultrathin conformal bio-integrated electronics Dawn John Mullassery Electrical and Computer Engineering University of British Columbia 1

The Paper

John A Rogers

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Overview • Motivation and Background • The technology • Future

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MOORE’s LAW “The observation made in 1965 by Gordon Moore, co-founder of Intel, that the number of transistors per square inch on integrated circuits had doubled every year since the integrated circuit was invented. Moore predicted that this trend would continue for the foreseeable future.” - Webopedia

http://www.singularitysymposium.com/moores-law.html

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Bio-Integration

6th International Conference on Intelligent and Advanced Systems 2016 (ICIAS2016), ieeemy.org, http://www.computerhope.com/jargon/e/edsac.htm,

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Bio-Integration

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Existing Technology – Utah

http://www.sci.utah.edu/~gk/abstracts/bisti03/, 7 Acute human brain responses to intracortical microelectrode arrays: challenges and future prospects - Eduardo et.al , doi: 10.3389/fneng.2014.00024

Electro - Corticography

Recording Human Electrocorticographic (ECoG) Signals for Neuroscientific Research and Real-time Functional Cortical Mapping N. Jeremy Hill et.al ; doi: 10.3791/3993

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Two main areas! • Bio-integrated or Biocompatible electronics • Transient electronics or Bioresorbable electronics

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Bio-Integrated Electronics • Epidermal Electronics

• Non – uniform surfaces inside the body 10

Bio-Integrated Electronics - Brain

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Bio-Integrated Electronics - Brain

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13 http://rogers.matse.illinois.edu/multimedia.php

Bio-Integrated Electronics - Cardiac Electrophysiology

A Conformal, Bio-Interfaced Class of Silicon Electronics for Mapping Cardiac Electrophysiology: Jonathan Viventi, et.,al; Flexible, foldable, actively multiplexed, high-density electrode array for mapping brain activity in vivo: Jonathan Viventi, et.al;

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Bio-Integrated Electronics - Cardiac Electrophysiology

A Conformal, Bio-Interfaced Class of Silicon Electronics for Mapping Cardiac Electrophysiology: Jonathan Viventi, et.,al;

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Bio-Integrated Electronics Spatiotemporal cardiac measurements

ECG sensor

Si strain gauge μ-ILED

pH sensor

Temperature sensor

3D multifunctional integumentary membranes for spatiotemporal cardiac measurements and stimulation across the entire epicardium. Lizhi Xu et.al;

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Bio-Integrated Electronics - Advantages • High resolution results • Less complicated process • Similar process can be used for epidermal electronics • Non – invasive method

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Transient Electronics Electronic systems that dissolve, resorb, or otherwise physically disappear at programmed rates or specific triggered times.

A Physically Transient Form of Silicon Electronics, et.al, 2012 VOL 337 SCIENCE

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Thin Silicon Membranes Dissolve


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Water Soluble Silicon Silicon for Transient Electronics

Silicon for Regular Electronics

• Silicon Thickness - 35 nm

• Silicon Thickness 700 µm

• Dissolution Time – 10 days

• Dissolution Time – 600 to 1000 years

• Water – 0.4 ml

• Water - 8 L


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Silk membranes dissolve

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Transient Electronic Device

23 A Physically Transient Form of Silicon Electronics, et.al, 2012 VOL 337 SCIENCE




Why a novel approach? • Biomedical Purposes • Environmental Sensors • Consumer Electronics

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Biomedical Application – Transient Electronics


Biomedical Application – Surgical Site Infections


Edible and Good! Magnesium ~ 100 mg vs ~ 300 mg

Silicon ~ 2 µg vs ~ 10 mg

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Biomedical Applications • Drug Delivery

• Electronic Aspirin

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Environmental sensors & e- waste

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Next Few Years & Future • Human body • Non – biomedical applications • Further R & D required

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Why will this be a classic paper? • New approach to existing techniques of biomedical methods • Any form of biological surface – with minimal invasion • Not limited to biomedical

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