Figure S1. Mixed acid-2,3-butanediol pathway (dashed lines represent the pathways that are active only under the aerobic conditions). TCA: tricarboxylic acids ...
Additional file 1-Metabolic pathways of acetoin and 2,3-butanediol in the bacteria Monosaccharide 1
CO2 12
Phosphoenolpyruvate ADP
CO2
2
ATP 16
H2 GTP
TCA
CoA-SH
CO2
18
Acetyl-CoA
NADH+ H+
3 NAD+ FAD
2CO2
11
NAD+
4
CoA-SH NAD+ CO2 NADH+ H+
14
H2O TPP
Acetylaldehyde
CO2
CoA-SH
9
NAD+
5
Ethanol
7
ATP
Acetate
NADH+ H+ NAD+
Acetyl-phosphate ADP
Fumarate
α-Acetolactate
CoA-SH NADH+ H+
Malate
Pyruvate
8
Pi 6
13
NAD+
Lactate
TPP
17
3
GDP 3 NADH+ H+ FADH2
NADH+ H+ NAD+
PYRUVATE
Formate
Oxaloacetate NADH+ H+
Acetoin
NADH+ H+ NAD+
15
Succinate
10
2,3-Butanediol
Figure S1. Mixed acid-2,3-butanediol pathway (dashed lines represent the pathways that are active only under the aerobic conditions). TCA: tricarboxylic acids cycle, Enzymes: 1, enzymes of glycolysis (and pentose phosphate pathway); 2, pyruvate kinase; 3, pyruvate-formate lyase; 4, acetaldehyde dehydrogenase; 5, ethanol dehydrogenase; 6, phospho-transacetylase; 7, acetate kinase; 8, acetolactate synthase; 9, acetolactate decarboxylase; 10, acetoin reductase (2,3-butanediol dehydrogenase); 11, lactate dehydrogenase; 12, phosphoenolpyruvate decarboxylase; 13, malate dehydrogenase; 14, fumarase; 15, succinate dehydrogenase; 16, formate-hydrogen lyase; 17, pyruvate dehydrogenase multienzyme complex; and 18, citroyl synthetase.