Salomon O, Rosenberg N,* Steinberg DM, Huna-Baron R, Moisseiev J, ...
Loewenthal R, Rosenberg N*, Kalt R, Dardik R, Landau M, Yahalom V, Avishai.
CURRICULUM VITAE
Nurit Rosenberg, Ph.D Institute of Thrombosis & Hemostasis Sheba Medical Center Tel Hashomer 52621 Israel Tel: +972-3-5302105 ext 2 Fax: +972-3-5351568 Email:
[email protected]
Education – Academic degrees 1975 – 1978
B.Sc. (with distinction) The Hebrew University of Jerusalem, Microbiology and Phytopathology
1978 – 1980
M.Sc (with distinction) The Hebrew University of Jerusalem, Genetics
1980
Certificate of teaching in Biology Hebrew University of Jerusalem, Israel
1985 – 1989
Ph.D - The Hebrew University of Jerusalem Thesis: Nucleic acids introduction into plant cells, using liposomes and other means.
1990 – 1993
Postdoctoral fellowship Weizmann Institute of Science, Rehovot, Israel. Molecular and cellular biology of wheat storage proteins
2009 – present
Senior Lecturer Tel Aviv University, Faculty of Medicine
2009-2012
B.A. (with distinction) Psychology, The Open University, Israel
Academic and Professional Experience 1979 – 1980
Research Assistant Volcani Center, The Agricultural Research Organization, Bet-Dagan, Israel. Department of Flowers and Ornamental Plants.
1985 – 1989
Israel Research Associate The Otto Warburg Center for Biotechnology in Agriculture, Rehovot.
2 1990 – 1993
Research Fellowship Weizmann Institute of Science, Rehovot, Israel. Plant Genetics and Biochemistry.
1993 – 2003
Junior Researcher Institute of Thrombosis and Hemostasis, Department of Hematology, Sheba Medical Center, Tel-Hashomer Head of Molecular Biology
2003- present Senior Researcher Institute of Thrombosis and Hemostasis, Department of Hematology & Amalia Biron research Institute of Thrombosis and Hemostasis, Sheba Medical Center, Tel-Hashomer Deputy of Laboratory Manager 2009 – present Senior Lecturer Tel Aviv University, Sackler Faculty of Medicine
Selected publications 1. Rosenberg N, Yatuv R, Orion Y, Zivelin A, Dardik R, Peretz H, Seligsohn U. 1997, Glanzmann thrombasthenia caused by an 11.2 kb deletion in the GPIIIa (3) is a second mutation in Iraqi-Jews that stemmed from a distinct founder. Blood 89:3654-3662. 2. Rosenberg N, Dardik R, Rosenthal E, Zivelin A, Seligsohn U. 1998, Mutations in the IIb and 3 genes that cause Glanzmann thrombasthenia can be distinguished by a simple procedure using transformed Blymphocytes. Thromb. Haemost. 79:244-248, 3. Yatuv RS, Rosenberg NPI, Zivelin AC, Peretz HC, Trakhtenbrot LT, Seligsohn UPI. 2001, Identification of a region in glycoprotein (GP)IIIa involved in subunit association with GPIIb – further lessons from Iraqi-Jewish Glanzmann thrombasthenia. Blood 98:1063-1069 4. Rosenberg N, Murata M, Ikeda Y, Opare-Sem O, Zivelin A, Geffen E, Seligsohn U. 2002. The frequent 5,10-methylenetetrahydro-folate reductase C677T polymorphism is associated with a common haplotype in Caucasians, Japanese and Africans. Am J Hum Genet 70:758-762, 5. Rosenberg N, Yatuv R, Sobolev V, Peretz H, Zivelin A, Seligsohn U. 2003, Major mutations in calf-1 and calf-2 domains of glycoprotein IIb in patients with Glanzmann thrombasthenia enable GPIIb/IIIa complex formation but abolish its transport from the endoplasmic reticulum to the Golgi apparatus. Blood 101: 4808-4815 6. Salomon O, Rosenberg N,* Steinberg DM, Huna-Baron R, Moisseiev J, Dardik R, Goldan O, Kurtz S, Ifrah A, Seligsohn U. 2004, Nonarteritic
3 anterior ischemic optic neuropathy is associated with a specific platelet polymorphism located on the glycoprotein Ib gene. Ophtomology 111: 184-188, *The first two authors contributed equally to this study. 7. Rosenberg N, Landau M, Luboshitz J, Rechavi G, Seligsohn U. 2004, A novel Phe171Cys mutation in integrin IIb causes Glanzmann thrombasthenia by abrogating IIb3 complex formation. J Thromb Haemost 2: 1167-1175. 8. Rosenberg N, Hauschner H, Peretz H, Mor-Cohen R, Landau M, Shenkman B, Kenet G, Coller BS, Awidi AA, Seligsohn U. 2005, A 13bp deletion in IIb gene is a founder mutation that predominates in Palestinian Arab patients with Glanzmann thrombasthenia. J Thromb Haemost 3:2764-2772 9. Peretz H, Rosenberg N, Landau M, Usher S, Nelson EJR, Mor-Cohen R, French DL, Mitchell BW, Chandy M, Coller BS, Srivastava A, Seligsohn U. 2006, Molecular Diversity of Glanzmann thrombasthenia in Southern India: New insights into mRNA splicing and structure-function correlations of αIIbβ3 integrin. Human Mutation. 27: 359-69 10. Rosenberg N, Lalezari S, Landau M, Shenkman B, Seligsohn U, Izraeli S. 2007, Trp207Gly in platelet glycoprotein Ib is a novel mutation which disrupts the connection between the leucine- rich repeat domain and the disulfide loop structure and causes Bernard Soulier syndrome. J Thromb Haemost. 5: 378-386. 11. Mor-Cohen R, Rosenberg N*, Peretz H, Landau M, Coller BS, Awidi A, Seligsohn U. 2007, Disulfide bond disruption by a Cys549Arg mutation in the 3 gene in 6 Jordanian families with Glanzmann thrombasthenia causes diminished production of constitutively active IIb3. Thromb Heamost 98:1257-65. 12. Mor-Cohen R, Rosenberg N, Landau M, Lahav J, and Seligsohn U. 2008, Specific cysteines in 3 are involved in disulfide bond exchange-dependent and -independent activation of IIb3. J. Biol. Chem 283:19235-44. 13. Hauschner H, Landau M, Seligsohn U, Rosenberg N. 2010, A unique interaction between αIIb and β3 in the head region is essential for outside-in signaling related functions of αIIbβ3 integrin. Blood 115:4542-50 14. Landau M, Rosenberg N. 2011, Molecular Insight into Human Platelet Antigens: Structural and Evolutionary Conservation Analyses offer New Perspective to Immunogenic Disorders. Transfusion 51:558-569 15. Mansour W, Einav Y, Hauschner H, Koren A, Seligsohn U, Rosenberg N. 2011, An Asn2Asp Glanzmann thrombasthenia-causing mutation in αIIb βpropeller blade-1 disrupts a calcium binding site in blade-6. J Thromb Haemost 9:192-200.
4 16. Hauschner H, Mor-Cohen R, Seligsohn U, Rosenberg N. A mutation in the β3 cytoplasmic tail causes variant Glanzmann thrombasthenia by abrogating transition of αIIbβ3 to an active state. J Thromb Haemost 10:289-297, 2012. 17. Mor-Cohen R, Rosenberg N, Einav Y, Zelzion E, Landau M, Mansour W, Averbukh Y, Seligsohn U. Integrin unique disulfide bonds in the EGF domains of β3 affect the structure and function of αIIbβ3 and αvβ3 integrins in a different manner. J Biol Chem 287:8879-91, 2012. 18. Loewenthal R, Rosenberg N*, Kalt R, Dardik R, Landau M, Yahalom V, Avishai O, Frenkel O, Gazit E, Steinberg DM, Lipitz S, Salomon O. Compound heterozygosity of HLA-DRB3*01:01 and HLA-DRB4*01:01 as a potential predictor of neonatal alloimmune thrombocytopenia (NAIT). Transfusion 53:344352, 2013.
Scientific publications - Original articles NURIT ROSENBERG, Ph.D
(as of April 2013) 1.
Gad AE, Elyashiv G, Rosenberg N. The induction of large unilamellar vesicles fusion by cationic polypeptide: the effects of mannitol, size, charge density and hydrophobicity of the cationic polypeptides. Biochem Biophys Acta- Biomembrane 860:314-324, 1986.
2.
Rosenberg N, Gad AE, Altman A, Navot N, Czosnek H. Liposome-mediated introduction of the chloramphenicol acetyl transferase (CAT) gene and its expression in tobacco protoplasts. Plant Mol Biol 10:185-191, 1988.
3.
Gad AE, Lubitz-Omero C, Rosenberg N, Altman A. Changes in the integrity of large unilamellar vesicles due to their interaction with tobacco cell suspensions. Plant Cell Rep 7:341-343, 1988.
4.
Rosenberg N, Shimoni Y, Altschuler Y, Levanony H, Volokita M, Galili G. A wheat (Triticum aestivum L.) -gliadin accumulates in dense protein bodies within the endoplasmic reticulum of yeast. Plant Physiol 102:61-69, 1993.
5.
Altschuler A, Rosenberg N, Harel R, Galili G. The N- and C-terminal regions regulate the transport of wheat -gliadin through the endoplasmic reticulum in Xenopus oocytes. Plant Cell 5:443-450, 1993.
6.
Shani N. Rosenberg N, Kasarda DD, Galili G. Mechanisms of assembly of wheat high molecular wheat glutenins inferred from expression of wild-type and mutant subunits in transgenic tobacco. J Biol Chem 269:8924-8930, 1994.
7.
Peretz H, Rosenberg N, Usher S, Graff E, Newman PJ, Coller BS, Seligsohn U. Glanzmann thrombasthenia associated with deletion-insertion and alternative splicing in glycoprotein IIb gene. Blood 85:414-420, 1995.
8.
Mandel H, Brenner B, Berant M, Rosenberg N, Lanir N, Jakobs C, Fowler B, Seligsohn U. Coexistence of hereditary homocystinuria and factor V Leiden – effect on thrombosis. N Engl J Med 334:763-768, 1996.
9.
Zivelin A, Rosenberg N, Peretz H, Amit Y, Kornbrot N, Seligsohn U. Improved method for genotyping apolipoprotein E polymorphisms by a PCR-based assay simultaneously utilizing two distinct restriction enzymes. Clin Chem 43:1657-1659, 1997.
10. Rosenberg N, Yatuv R, Orion Y, Zivelin A, Dardik R, Peretz H, Seligsohn U. Glanzmann thrombasthenia caused by an 11.2 kb deletion in the GPIIIa ( 3) is a second mutation in Iraqi-Jews that stemmed from a distinct founder. Blood 89:3654-3662, 1997. 11. Dardik R, Kaufmann Y, Savion N, Rosenberg N, Shekman B, Varon D. Platelets mediate tumor cell adhesion to the subendothlium under flow conditions: involvement of platelet GPIIb-IIIa and tumor cell v integrins. Int J Cancer 70:201-207, 1997.
6 12. Yatuv R, Rosenberg N, Dardik R, Brenner B, Seligsohn U. Glanzmann thrombasthenia in two Iraqi-Jewish siblings is caused by a novel splice junction mutation in the glycoprotein IIb. Blood Coagul Fibrinolysis 9:285-298, 1998. 13. Rosenberg N, Dardik R, Rosenthal E, Zivelin A, Seligsohn U. Mutations in the IIb and 3 genes that cause Glanzmann thrombasthenia can be distinguished by a simple procedure using transformed B-lymphocytes. Thromb Haemost 79:244-248, 1998. (A figure of this article was chosen to be presented on the cover). 14. Zivelin A, Rosenberg N, Fair S, Kornbrot N, Peretz H, Mannhalter C, Horollou MH, Seligsohn U. A single genetic origin for the common prothrombotic G20210A polymorphism in prothrombin gene. Blood 92:1119-1124, 1998. 15. Salomon O, Moisseiev J, Rosenberg N, Vidne O, Yassur I, Zivelin A, Treister G, Steinberg DM, Seligsohn U. Analysis of genetic polymorphisms related to thrombosis and other risk factors in patients with retinal vein occlusion. Blood Coagul Fibrinolysis 9:617-622, 1998. 16. Inbal A, Freimark D, Modan B, Chetrit A, Matetzky S. Rosenberg N, Dardik R, Baron Z, Seligsohn U. Synergistic effects of prothrombotic polymorphisms and atherogenic factors on the risk of myocardial infarction in young males. Blood 93:2186-2190, 1999. 17. Salomon O, Apter S, Shaham D, Hiller N, Bar-Ziv J, Itzchak Y, Gitel S, Rosenberg N, Strauss S, Kaufman N, Seligsohn U. Risk factors associated with postpartum ovarian vein thrombosis. Thromb Haemost 82:1015-1019, 1999. 18. Salomon O, Steinberg DM, Zivelin A, Gitel S, Dardik R, Rosenberg N, Berliner S, Inbal A, Many A, Lubetsky A, Varon D, Martinowitz U, Seligsohn U. Single and combined prothrombotic factors in patients with idiopathic venous thromboembolism: prevalence and risk assessment. Arterioscl. Thromb Vasc Biol 19:511-518, 1999. 19. Salomon O, Huna-Baron R, Kurtz S, Steinberg DM, Moisseiv J, Rosenberg N, Yassur I, Vidne O, Zivelin A, Gitel S, Davidson J, Ravid B, Seligsohn U. Analysis of prothrombotic and vascular risk factors in patients with nonarteritic anterior ischemic optic neuropathy. Ophthalmology 106:739-74, 1999. Cited in: The Year Book of Ophthalmology 2000. Wilson RP eds., pp. 213-214. 20. Hayek S, Kenet G, Lubetsky A, Rosenberg N, Gitel S, Weintroub S. Does thrombophilia play an aetiological role in Legg-Calve-Perthes disease? J Bone Joint Surg [Br] 81:687690, 1999. 21. Kenet G, Sadetzki S, Murad H, Martinowitz U, Rosenberg N, Gitel S, Rechavi G, Inbal A. Factor V Leiden and anti phospholipid antibodies are significant risk factors for ischemic stroke in children. Stroke 31:1283-1288, 2000. 22. Salomon O, Dardik R, Steinberg DM, Kurtz S, Rosenberg N, Moisseeiev J, Huna-Baron R. The role of angiotensin converting enzyme and angiotensin II type 1 receptor gene polymorphisms in patients with nonarteritic anterior ischemic optic neuropathy. Ophthalmology 107:1717-1720, 2000.
7 23. Salomon O, Rosenberg N, Zivelin A, Steinberg DM, Kornbrot N, Dardik R, Inbal A, Seligsohn U. Methionine synthase A2756G and methylenetetrahydrofolate reductase A1298C polymorphisms are not risk factors for idiopathic venous thromboembolism. Hematology J 2:38-41, 2001. 24. Yatuv R, Rosenberg N, Zivelin A, Peretz H, Trakhtenbrot L, Seligsohn U. Identification of a region in glycoprotein (GP)IIIa involved in subunit association with GPIIb – further lessons from Iraqi-Jewish Glanzmann thrombasthenia. Blood 98:1063-1069, 2001. 25. Mor-Cohen R, Zivelin A, Rosenberg N, Shani M, Muallem S, Seligsohn U. Identification and functional analysis of two novel mutations in the multi-drug resistance protein 2 gene in Israeli patients with Dubin-Johnson syndrom. J Biol Chem 276:3692330, 2001. 26. Salomon O, Huna-Baron R, Moisseiev J, Rosenberg N, Rubovitz A, Steinberg DM, Davidson J, Sela BA, Seligsohn U. Thrombophilia as a cause for central and branch retinal artery occlusion in patients without an apparent embolic source. Eye 15:511-514, 2001. 27. Striefler JY, Rosenberg N, Chetrit A, Eskaraev R, Sela BA, Dardik R, Zivelin A, Ravid B, Davidson J, Seligsohn U, Inbal A. Cerebrovascular events in patients with significant stenosis of the carotid artery are associated with hyperhomocyteinemia and platelet antigen-1 (Leu33Pro) polymorphism. Stroke 32:2753-2758, 2001. 28. Rosenberg N, Murata M, Ikeda Y, Opare-Sem O, Zivelin A, Geffen E, Seligsohn U. the frequent 5,10-methylenetetrahydrofolate reductase C677T polymorphism is associated with a common haplotype in Caucasians, Japanese and Africans. Am J Hum Genet 70:758-762, 2002. 29. Zivelin A, Bauduer F, Ducout L, Peretz H, Rosenberg N, Yatuv R, Seligsohn U. Factor XI deficiency in French Basques is predominantly Caused by ancestral C38R mutation in the factor XI gene. Blood 99:2448-2454, 2002. 30. Rosenberg N, Zivelin A, Chetrit A, Dardik R, Kornbrot N, Freimark D, Inbal A. Effects of platelet membrane glycoprotein polymorphisms on the risk of myocardial infarction in young males. Israel Med Assoc 4:411-414, 2002. 31. Carp H, Salomon O, Seidman D, Dardik R, Rosenberg N, Inbal A. Prevalence of genetic markers for thrombophilia in recurrent pregnancy loss. Hum Reprod 17:1633-1637, 2002. 32. Rosenberg N, Yatuv R, Sobolev V, Peretz H, Zivelin A, Seligsohn U. Major mutations in calf-1 and calf-2 domains of glycoprotein IIb in patients with Glanzmann thrombasthenia enable GPIIb/IIIa complex formation but abolish its transport from the endoplasmic reticulum to the Golgi apparatus. Blood 101: 4808-4815, 2003. 33. Salomon O, Steinberg DM, Dardik R, Rosenberg N, Zivelin A, Tamarin I, Ravid B, Berliner S, Seligsohn U. Inherited factor XI deficiency confers no protection against acute myocardial infarction. J Thromb Haemost 1:658-661 (in focus), 2003.
8 34. Kenet G, Hayek S, Mor M, Lubetsky A, Miller L, Rosenberg N, Mosheiff R, Itzchaki M, Elstein D, Wientroub S, Zimran A. The 1226G (N370S) Gaucher mutation among patients with Legg-Calve-Perthes disease. Blood Cells Mol Dis 31:72-74, 2003. 35. Horton MA, Massey HM, Rosenberg N, Nicholls B, Seligsohn U, Flanagan AM. Upregulation of osteoclast 2 1 integrin compensates for lack of v 3 vitronectin receptor in Iraqi-Jewish-type Glanzmann thrombasthenia. Brit J Haematol 122:950-957, 2003. 36. Kenet G, Maayan A, Rosenberg N, Sela BA, Mazkeret R, Ifrah A, Kunit J. Thrombophilia does not increase risk for neonatal complications in preterm infants. Thomb Hemost 90:823-828, 2003. 37. Figlin E, Chetrit A, Shahar A, Shpilberg O, Zivelin A, Rosenberg N, Brok-Simoni F, Gadoth N, Sela BA, Seligsohn U. High prevalence of vitamin B12 and folic acid in elderly subjects in Israel. Brit J Haematol 123: 696-701, 2003. 38. Salomon O, Rosenberg N*, Steinberg DM, Huna-Baron R, Moisseiev J, Dardik R, Goldan O, Kurtz S, Ifrah A, Seligsohn U. Nonarteritic anterior ischemic optic neuropathy is associated with a specific platelet polymorphism located on the glycoprotein Ib gene. Ophtalmology 111:184-188, 2004. 39. Segal A, Zivelin A, Rosenberg N, Ginsburg O, Shpilberg O, Seligsohn U. A mutation in LMAN1 (ERGIC-53) causing combined factors V and VIII deficiency is prevalent in Jews originating from the island of Djerba in Tunis. Blood Coagul Fibrinolysis 15: 99102, 2004. 40. Leiba M, Seligsohn U, Sidi Y, Harats D, Sela BA, Griffin JH, Livne A, Rosenberg N, Gelernter I, Gur H, Ehrenfeld M. Thrombophilic factors are not the leading cause of thrombosis in Behcet's disease. Ann Rheum Dis 63:1445-9, 2004. 41. Rosenberg N, Landau M, Luboshitz J, Rechavi G, Seligsohn U. A novel Phe171Cys mutation in integrin IIb causes Glanzmann thrombasthenia by abrogating αIIbβ3 complex formation. J Thromb Haemost 2:1167-1175, 2004. 42. Vysokovsky A, Saxema R, Landau M, Zivelin A, Eskaraev R, Rosenberg N, Seligsohn U, Inbal I. Seven novel mutations in the factor XIII A-subunit gene causing hereditary factor XIII deficiency in ten unrelated families. J Thromb Haemost 2:1790-1797, 2004. 43. Fromovich-Amit Y, Zivelin A, Rosenberg N, Tamary H, Landau M, Seligsohn U. Characterization of mutations causing factor VII deficiency in 61 unrelated Israeli patients. J Thromb Haemost 2:1774-1781, 2004. 44. Salomon O, Seligsohn U, Steinberg DM, Zalel Y, Lerner A, Rosenberg N, Pshithizki M, Oren M, Ravid B, Davidson J, Sciff E, Achiron R. The common prothrombotic factors in nuliparous women do not compromise blood flow in the feto-maternal circulation and are not associated with preeclampsia or intrauterine growth restriction. Am J Obstet Gynecol 191:2002-2009, 2004.
9 45. Mor-Cohen R, Zivelin A, Rosenberg N, Goldberg I, Seligsohn U. A novel ancestral splicing mutation in the multidrug resistance protein 2 gene causes Dubin-Johnson syndrome in Ashkenazi Jewish patients. Hepatol Res 31:104-111, 2005. 46. Losonczy G, Rosenberg N, Kiss C, Kappelmayer J, Vereb G, Kerenyi A, Balogh I, Muszbek L. A novel homozygous mutation (1619delC) in GPIIb gene associated with Glanzmann thrombasthenia, the decay of GPIIb-mRNA and the synthesis of a truncated GPIIb unable to form complex with GPIIIa. Thromb Heamost 93:904-909, 2005. 47. Salomon O, Steinberg DM, Pshithizki M, Zalel Y, Lerner A, Rosenberg N, Achiron R. The influence of protrombotic polymorphisms and obstetrical and medical variables on the length of secondary postpartum hemorrhage. J Women's Health 14:306-310, 2005. 48. Fromovich-Amit Y, Zivelin A, Rosenberg N, Landau M, Rosa JP, Seligsohn U. Of four mutations in the factor VII gene in Tunisian patients, one novel mutation (Ser339Phe) in three unrelated families abrogates factor X activation. Blood Coagul Fibrinolysis 16:369-374, 2005. 49. Rosenberg N, Hauschner H, Peretz H, Mor-Cohen R, Landau M, Shenkman B, Kenet G, Coller BS, Awidi AA, Seligsohn U. A 13bp deletion in IIb gene is a founder mutation that predominates in Palestinian Arab patients with Glanzmann thrombasthenia. J Thromb Haemost 3:2764-2772, 2005. 50. Vysokovsky A, Rosenberg N*, Dardik R, Seligsohn U, Inbal A. Effect of four missense mutations in the factor XIII A-subunit gene on protein stability: studies with recombinant proteins. Blood Coagul Fibrinolysis 17: 125-130, 2006. 51. Peretz H, Rosenberg N, Landau M, Usher S, Nelson EJR, Mor-Cohen R, French DL, Mitchell BW, Chandy M, Coller BS, Srivastava A, Seligsohn U. Molecular Diversity of Glanzmann thrombasthenia in Southern India: New insights into mRNA splicing and structure-function correlations of αIIbβ3 integrin. Human Mutation 27:359-369, 2006. 52. Salomon O, Moisseiev J, Vilganski T, Dardik R, Kurtz S, Springer E, Steinberg DM, Rosenberg N. Role of five platelet membrane glycoprotein polymorphisms in branch retinal vein occlusion. Blood Coagul Fibrinolysis 17: 485-488, 2006. 53. Rosenberg N, Lalezari S, Landau M, Shenkman B, Seligsohn U, Izraeli S. Trp207Gly in platelet glycoprotein Ib is a novel mutation which disrupts the connection between the leucine- rich repeat domain and the disulfide loop structure and causes Bernard-Soulier syndrome. J Thromb Haemost 5: 378-386, 2007. 54. Mor-Cohen R, Zivelin A, Fromovich-Amit Y, Kovalski V, Rosenberg N, Seligsohn U. Age estimates of ancestral mutations cauing factor VII deficiency and Dubin-Johnson syndrome in Iranian and Moroccan Jews are consistent with ancient Jewish migrations. Blood Coagul Fibrinolysis. 18:139-144, 2007. 55. Losonczy G, Rosenberg N, Boda Z, Vereb G, Kappelmayer J, Hauschner H, Bereczky Z, Muszbek L. Three novel mutations in the glycoprotein IIb gene in a patient with type II Glanzmann thrombasthenia. Haematologica 92:698-701, 2007.
10 56. Haran MZ, Lichman I, Berebbi A, Weinmanbn E, Rosenberg N. Unbalanced protein S deficiency due to warfarin treatment as a possible cause for thrombosis. Brit J Hematol 139:310-1, 2007. 57. Mor-Cohen R, Rosenberg N, Peretz H, Landau M, Coller BS, Awidi A, Seligsohn U. Disulfide bond disruption by a Cys549Arg mutation in the 3 gene in 6 Jordanian families with Glanzmann thrombasthenia causes diminished production of constitutively active αIIbβ3. Thromb Heamost 98:1257-65, 2007. 58. Mor-Cohen R, Rosenberg N, Landau M, Lahav J, and Seligsohn U. Specific cysteines in β3 are involved in disulfide bond exchange-dependent and -independent activation of αIIbβ3. J. Biol. Chem 283:19235-44, 2008. 59. Kenet G, Ezra E, Wientroub S, Steinberg DM, Rosenberg N, Waldman D, Hayek S. Legg Calve Perthes disease- in search of genetic associations: collagen mutations, Gaucher disease and thrombophilia J Bone Joint Surg [Br] 90-B: 1507-11, 2008. 60. Landau D, Rosenberg N, Zivelin A, Starretz-Hacham O, Kapelushnik Y. Familial factor VII deficiency with fetal and neonatal fatal cerebral hemorrhage associated with homozygosis to Gly180Arg mutation. Hemophilia 2009 15:774-8, 2009. 61. Zucker M, Zivelin A, Landau M, Rosenberg N, Seligsohn U. Three residues at the interface of factor XI monomers augment covalent dimerization of factor XI. J Thromb Haemost 7: 970-5, 2009. 62. Manaster Y, Shenkman B, Rosenberg N, Savion N. Allicin and disulfiram enhance platelet integrin IIb- 3 – fibrinogen binding. Thromb. Res. 124:477-82. 2009. 63. Hauschner H, Landau M, Seligsohn U, Rosenberg N. A unique interaction between αIIb and β3 in the head region is essential for outside-in signaling related functions of αIIbβ3 integrin. Blood 115:4542-50, 2010 IF-10.37, Hematology 2/61. 64. Landau M, Rosenberg N. Molecular Insight into Human Platelet Antigens: Structural and evolutionary conservation analyses offer new perspective to immunogenic disorders. Transfusion 51:558-569, 2010 65. Mansour W, Einav Y, Hauschner H, Koren A, Seligsohn U. Rosenberg N An IIb mutation in patients with Glanzmann thrombasthenia located in the N-terminus of blade 1 of the β-propeller [Asn2Asp ] disrupts a calcium binding site in blade 6 . J Thromb Haemost, 9:192-200, 2011 66. Zucker M, Rosenberg N, Peretz H, GreenD, Bauduer F, Zivelin A, Seligsohn U. Point mutations regarded as missense mutations cause splicing defects in the factor XI gene J Thromb Haemost 9:1977-84, 2011. Commentary by Duga S. Asselta R. Mutations in disguise. J Thromb Haemost 9:1973-6
11 67. Hauschner H, Mor-Cohen R, Seligsohn U, Rosenberg N. A mutation in the β3 cytoplasmic tail causes variant Glanzmann thrombasthenia by abrogating transition of αIIbβ3 to an active state. J Thromb Haemost 10:289-297, 2012. 68. Mor-Cohen R, Rosenberg N, Einav Y, Zelzion E, Landau M, Mansour W, Averbukh Y, Seligsohn U. Integrin unique disulfide bonds in the EGF domains of β3 affect the structure and function of αIIbβ3 and αvβ3 integrins in a different manner. J Biol Chem 287:8879-91, 2012. 69. Loewenthal R, Rosenberg N*, Kalt R, Dardik R, Landau M, Yahalom V, Avishai O, Frenkel O, Gazit E, Steinberg DM, Lipitz S, Salomon O. Compound heterozygosity of HLA-DRB3*01:01 and HLA-DRB4*01:01 as a potential predictor of neonatal alloimmune thrombocytopenia (NAIT). Transfusion 53:344-352, 2013. 70. Maayan-Metzger A, Lubetsky A, Kuint J, Rosenberg N, Simchen MJ, Kuperman A, Strauss T, Sela BA, Kenet G. The Impact of Genetic and Environmental Factors on Homocysteine Levels in Preterm Neonates. Pediatr Blood Cancer 60:659-662, 2013.
