Department of Pharmacy (Pharmaceutics) | Sagar savale
Oral Drug Delivery Systems
Mr. Sagar Kishor Savale [Department of Pharmaceutics] [email protected]
Contents Drug Delivery Systems (DDS)
Sustained and Controlled Release Drug Delivery System (SRDDS & CRDDS) Continuous Release System (CRS)
Delayed Transit & Continuous Release System (Gastroretentive DDS) Pulsatile Drug Delivery System (PDDS) Delayed Release Systems: (Intestinal specific and Colon Specific)
DRUG: Drug is any substance is intended is used as orally applied a topically for the purpose of used of mitigation, treatment, prevention, cure and Diagnosis of disease and disorder and maintain the good quality of health is known has Drug.
DOSAGE FORM - Dosage forms are the means by which drug molecules are delivered to sites of action within the body. Drug Active pharmaceutical + Excipients ingredient (API) DRUG DELIVERY SYSTEMS The system to deliver the drug to the body to produced desired therapeutic action and activity against diseases and disorders is known as Drug delivery system.
TYPES OF DRUG DELIVERY SYSTEM 1. 2. 3. 4. 5.
Conventional Drug Delivery System Oral Drug Delivery System Sustained Drug Delivery System Controlled Drug Delivery System Targeted Drug Delivery System
Plasma concentration Curve
Plasma concentration time profile (Sustained Release Drug)
The history of controlled release technology is divided into three time periods From 1950 to 1970 was the period of sustain drug release From 1970 to 1990 was involved in the determination of the needs of the control drug delivery Post 1990 modern era of controlled release technology INTRODUCTION
In the conventional therapy aliquot quantities of drugs are introduced into the system at specified intervals of time with the result that there is considerable fluctuation in drug concentration level as indicated in the figure. HIGH
However, an ideal dosage regimen would be one, in which the concentration of the drug, nearly coinciding with minimum effective concentration (M.E.C.), is maintained at a constant level throughout the treatment period. Such a situation can be graphically represented by the following figure
Plasma Profile of different dosage
Different Order Release pattern
Drug levels in the blood with
Traditional drug dosing- the level rises after each administration of the drug and then decreases until the next administration
Sustain Release Drug Delivery System Definition: “Drug Delivery system that are designed to achieve prolonged therapeutic effect by continuously releasing medication over an extended period of time after administration of single dose” is known as Sustained drug Delivery system. The basic goal of therapy is to achieve steady state blood level that is therapeutically effective and non toxic for an extended period of time. The design of proper dosage regimen is an important element in accomplishing this goal.
Controlled Release Drug Delivery System Definition: “Drug Delivery System in which maintain constant level of drug in blood and tissue in extended period of time” is known as Controlled release system. Delivers the drug at a pre determined rate for a specified period of time Controlled release is perfectly zero order release that is the drug release over time irrespective of concentration.
Differences between sustained and controlled Release drug delivery system Sustained release Drug Delivery System
Controlled release Drug Delivery System
“Drug Delivery system that are designed to achieve prolonged “Drug Delivery System in which maintain constant level of drug therapeutic effect by continuously releasing medication over an in blood and tissue in extended period of time” is known as extended period of time after administration of single dose” is Controlled release system. known as Sustained drug Delivery system. Slow release of drug in extended period of time
Maintain constant level of drug in Prolonged Period of Time
First order Kinetic Process
Zero order kinetic Process
Drug release is based on concentration
Drug release is not concentration dependent
It is not site specific delivery of drug
It is having site specific delivery of drug
It is reproducible and re-predictable
It is Producible and Predictable
Synonyms of Sustained & Controlled release drug delivery system
Slow release DDS Programmed Release Timed release Repository Dosage Forms Prolonged Release Extended Release Depot Formulations Delayed release Modified release Targeted drug delivery
Objective of SR/ CR DDS To control the drug delivery to ensure safety and enhance efficacy of drug with improved patient compliance.
Concept of sustained release formulation Mechanism: The Concept of sustained release formulation can be divided in to two considerations i.e. release rate & dose consideration
A] Release rate consideration: In conventional dosage form Kr>Ka in this the release of drug from dosage form is not rate limiting step.
The above criteria i.e. (Kr>Ka) is in case of immediate release, where as in non immediate (Kr