Effect of probiotic containing lactobacillus ...

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bifidobacterium and streptococcus thermophilus in critically ill patients. Mehrangiz Ebrahimi-Mamaghani, Sarvin Sanaie, Ata Mahmoudpour,. Hadi Hamishehkar.
Effect of probiotic containing lactobacillus, bifidobacterium and streptococcus thermophilus in critically ill patients Mehrangiz Ebrahimi-Mamaghani, Sarvin Sanaie, Ata Mahmoudpour, Hadi Hamishehkar Student Research Center, Tabriz University of Medical Sciences, Tabriz, Iran Objective: Sepsis is the most common cause of death in intensive care units. Destruction of intestinal barrier function and increased translocation of bacteria to systemic blood flow can lead to sepsis. Probiotics may have beneficial effects in improvement of critically ill patients by modulating intestinal barrier and reduction of inflammation. The aim of this trial was to determine the effect of probiotic on inflammatory biomarkers and mortality rate of sepsis in critically ill patients in the intensive care unit. Methods: This double-blind, randomized controlled trial was conducted on 40 critically ill patients admitted to the intensive care unit. They were randomly assigned to receive placebo or probiotic for 7 days. APACHE score, Sequential Organ Failure Assessment (SOFA) and systemic concentrations of interleukin-6 (IL-6), procalcitonin (PCT) and protein C were measured before initiation of the study and on days 4 and 7. Also, 28-day mortality was evaluated for each patient. Table 1. Changes in patients' biomarkers and scores between the 7th and the 1st day of study

Control group *

Probiotic group

P value

−140.05(−190.01 - −90.08)

0.004

IL-6

−15.75(−85.43 - 53.93 )

PCT

−0.15(−0.85 – 0.54)

−1.20(−1.69 - −0.72)

0.013

Protein C

−0.87(−2.74 – 0.98)

5.40(4.09 – 6.70)