Elevated Macrophage Migration Inhibitory Factor

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Abstract: Objective: Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine that promotes atherogenesis by enhancing the uptake of oxidized ...
The Endocrine Society's 90th Annual Meeting & Expo, June 15–18, 2008 – San Francisco, CA CLINICAL – Phenotypic Spectrum & Metabolism in PCOS

Elevated Macrophage Migration Inhibitory Factor Levels in Polycystic Ovary Syndrome – Relationship with Abdominal Adiposity, C-Reactive Protein and Hyperandrogenism 1 2 3 2 Frank González , Neal S Rote , John P Kirwan and Judi Minium

1Obstetrics and Gynecology, Indiana University School of Medicine, Indianapolis, IN 2Reproductive Biology, Case Western Reserve School of Medicine, Cleveland, OH 3Pathobiology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH

Presentation Number: P3-564 Date of Presentation: June 17, 2008 Abstract: Objective: Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine that promotes atherogenesis by enhancing the uptake of oxidized low density lipoprotein by foamy macrophages in atherosclerotic plaques. C-reactive protein (CRP), a major predictor of atherosclerosis, is thought to play a functional role similar to MIF in atherogenesis. We examined the status of circulating MIF, and its relationship with body composition and circulating CRP, LH and androgens in women with PCOS compared to ovulatory controls. Methods: Twelve women with PCOS (6 lean, 6 obese) between ages 18-40, diagnosed on the basis of oligomenorrhea and hyperandrogenemia, and 12 ovulatory controls (6 lean, 6 obese) of similar age participated in the study. Subjects with diabetes, inflammatory illnesses or other endocrinopathies were excluded. MIF and CRP levels were measured in plasma by ELISA, and LH, testosterone and androstenedione levels were measured in serum by RIA within 5-8 days of menses. Body composition was assessed by DEXA.

Conclusions: These preliminary data indicate that in PCOS, circulating MIF levels are elevated independent of obesity. However, abdominal adiposity and hyperandrogenism may be additional perpetuators of this proinflammatory, proatherogenic phenomenon in PCOS.

80 * p < 0.04 † p < 0.02

Plasma MIF (ng/ml)

Results: Age, body mass index, percent (%) total body fat and % truncal fat were similar in women with PCOS and weight-matched controls. MIF levels were higher (p