Family Practice, 2016, Vol. 33, No. 2, 127–132 doi:10.1093/fampra/cmv104
Epidemiology
Empiric antibiotic treatment for urinary tract infection in preschool children: susceptibilities of urine sample isolates Christopher C Butlera,b,*, Kathryn O’Brienc, Mandy Woottond, Timothy Picklesd, Kerenza Hoode, Robin Howed, Cherry-Ann Waldrone, Emma Thomas-Jonese, Jan Dudleyf, Judith Van Der Voortg, Kate Rumsbyh, Paul Littleh, Harriet Downingi, Kim Harmanh and Alastair D Hayi on behalf of the DUTY Study Team Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, bCwm Taf University Health Board, Abercynon, cDivision of Population Medicine, School of Medicine, Cardiff University, Neuadd Meirionnydd, Heath Park, Cardiff CF14 4YS, dSpecialist Antimicrobial Chemotherapy Unit, Public Health Wales Microbiology Cardiff, University Hospital Wales, Heath Park, Cardiff, eSouth East Wales Trials Unit (SEWTU), Centre for Trials Research, Cardiff University, 7th Floor Neuadd Meirionnydd, Heath Park, Cardiff CF14 4YS, fBristol Royal Hospital for Children, University Hospitals Bristol, NHS Foundation Trust, Bristol, gDepartment of Paediatrics and Child Health, University Hospital of Wales, Cardiff, hPrimary Care and Population Sciences Division, University of Southampton, Southampton and iCentre for Academic Primary Care, NIHR School of Primary Care Research, School of Social and Community Medicine, University of Bristol, Bristol, UK. a
*Correspondence to Christopher C Butler, Nuffield Department of Primary Care Health Sciences, University of Oxford, New Radcliffe House, Radcliffe Observatory Quarter, Woodstock Road, Oxford OX2 6NW, UK; E-mail:
[email protected]
Abstract Background. Antibiotic treatment recommendations based on susceptibility data from routinely submitted urine samples may be biased because of variation in sampling, laboratory procedures and inclusion of repeat samples, leading to uncertainty about empirical treatment. Objective. To describe and compare susceptibilities of Escherichia coli cultured from routinely submitted samples, with E. coli causing urinary tract infection (UTI) from a cohort of systematically sampled, acutely unwell children. Methods. Susceptibilities of 1458 E. coli isolates submitted during the course of routine primary care for children
