Endothelial Nitric Oxide Synthase Gene Polymorphisms ... - iris.sssup.it

2 downloads 4 Views 134KB Size Report
Background: Endothelial nitric oxide synthase (eNOS) could be a candidate gene for coronary artery disease. (CAD). This study investigated the relationship of ...

Clinical Chemistry 49:3 389 –395 (2003)

Molecular Diagnostics and Genetics

Endothelial Nitric Oxide Synthase Gene Polymorphisms and Risk of Coronary Artery Disease Maria Giovanna Colombo,* Umberto Paradossi, Maria Grazia Andreassi, Nicoletta Botto, Samantha Manfredi, Serena Masetti, Andrea Biagini, and Aldo Clerico

Background: Endothelial nitric oxide synthase (eNOS) could be a candidate gene for coronary artery disease (CAD). This study investigated the relationship of the eNOS Glu2983 Asp and T7863 C polymorphisms with the presence and severity of CAD in the Italian population. Methods: We enrolled 415 unrelated individuals who underwent coronary angiography. The severity of CAD was expressed by means of the Duke score. The eNOS Glu2983 Asp and T7863 C variants were analyzed by PCR. Results: There was significant linkage disequilibrium between the two eNOS polymorphisms (P

Suggest Documents