Enterotoxin-Specific Immunoglobulin E Responses in Humans after ...

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Cholera toxin (CT)-specific antibody responses of the immunoglobulin E (IgE) ... oral cholera vaccine showed no IgE responses to CT (P value not significant).

INFECTION AND IMMUNITY, Oct. 2000, p. 6077–6081 0019-9567/00/$04.00⫹0 Copyright © 2000, American Society for Microbiology. All Rights Reserved.

Vol. 68, No. 10

Enterotoxin-Specific Immunoglobulin E Responses in Humans after Infection or Vaccination with Diarrhea-Causing Enteropathogens FIRDAUSI QADRI,1* MUHAMMAD ASADUZZAMAN,1 CHRISTINE WENNERÅS,2 GOLAM MOHI,1 M. JOHN ALBERT,1 MOHAMMAD ABDUS SALAM,1 R. BRADLEY SACK,3 MARIANNE JERTBORN,2 JERRY R. MCGHEE,4 DAVID A. SACK,1,3 2 AND JAN HOLMGREN International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh1; Department of Medical Microbiology and Immunology, Göteborg University, Göteborg, Sweden2; Department of International Health, Johns Hopkins University, Baltimore, Maryland3; and The Immunobiology Vaccine Center, University of Alabama at Birmingham, Birmingham, Alabama4 Received 28 February 2000/Accepted 19 July 2000

Cholera toxin (CT)-specific antibody responses of the immunoglobulin E (IgE) isotype in the sera of adult patients suffering from infection with either Vibrio cholerae O1, V. cholerae O139, or enterotoxigenic Escherichia coli (ETEC) were analyzed and compared with those in the sera of volunteers immunized with a bivalent B subunit O1/O139 whole-cell cholera vaccine. A significant IgE response to CT was observed in 90% of the patients with V. cholerae O1 infection (18 of 20; P ⴝ

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