ever, the carbapenems (imipenem [IPM], panipenem [PAPM], and meropenem [MEM]) do not show high levels of activity against MRSA. It has been previously ...
Epigallocatechin Gallate Synergistically Enhances the Activity of Carbapenems against Methicillin-Resistant Staphylococcus aureus Zhi-Qing Hu,1* Wei-Hua Zhao,1 Nozomi Asano,1 Yoshiyuki Yoda,1 Yukihiko Hara,2 and Tadakatsu Shimamura1 Department of Microbiology and Immunology, Showa University School of Medicine,1 and Tokyo Food Techno Co. Ltd.,2 Tokyo, Japan Received 13 April 2001/Returned for modification 22 August 2001/Accepted 25 October 2001
Combinations of carbapenems and epigallocatechin gallate (EGCg; a main constituent of tea catechins) showed potent synergy against 24 clinical isolates of methicillin-resistant Staphylococcus aureus (MRSA). MICs of imipenem in the presence of EGCg at 3.125, 6.25, 12.5, and 25 g/ml, were restored to the susceptible breakpoint (
