Mtb & IFNγ-stimulated genes in macrophages. Gene expression changes (mean fold difference to unstimulated macrophages from eight different donors) for ...
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European Journal of Immunology Supporting Information for DOI 10.1002/eji.201141841
Transcriptional profiling of innate and adaptive human immune responses to mycobacteria in the tuberculin skin test
Gillian S. Tomlinson, Tamaryn J. Cashmore, Paul T. G. Elkington, John Yates, Rannakoe J. Lehloenya, Jhen Tsang, Michael Brown, Robert F. Miller, Keertan Dheda, David R. Katz, Benjamin M. Chain and Mahdad Noursadeghi
Mtb & IFNγ-stimulated genes in macrophages Gene expression changes (mean fold difference to unstimulated macrophages from eight different donors) for data sets derived from Mtb and IFNγ stimulated macrophages from three donors are compared for each of the top 20 gene expression changes induced by 424h Mtb or IFNγ stimulation. These data show that innate immune responses to Mtb and IFNγ stimulated changes show limited overlap.
F
M
M
F
F
F
M
M
F
M
F
F
M
M
F
F
F
F
F
F
V1*
V2*
V3
V4
V5
V6
V7*
V8*
CT1*
CT2*
CT3
CT4*
CT5
CT6
CT7
CT8
CT9*
CT10
CT11
CT12
44
39
31
36
39
51
41
43
44
35
37
49
32
22
40
38
33
22
22
26
Age
Mixed
Mixed
White
Mixed
Mixed
Mixed
Black
White
Mixed
Black
Black
White
White
Mixed
White
Black
White
White
White
White
Ethnicity
24 21 35 0 0 35 25 24 0 0 0 52
8 8 8 8 8 8 8 8 9 8 8 8 8 8 8 8 8 8
8 9 8 8 8 8
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
0
8
9
0
0
10
0
0
11
11
8
8
TST (mm)
Previous TB
BCG
*Samples analysed by microarrays obtained from these subjects
Gender
Study ID
SUPPLEMENTARY TABLE 1: STUDY SUBJECTS DEMOGRAPHIC DATA
