Guido Dorner,1 Gabriele Zanaschka,1 Christa Mensik1 & Hans-Georg Eichler1. 1Department of ..... 11 Schnurr E, Lahme W, Küppers H. Measurement of renal.
Br J Clin Pharmacol 1998; 45: 71–75
Exogenous L-arginine does not affect angiotensin II-induced renal vasoconstriction in man Michael Wolzt,1 Ara Ugurluoglu,2 Leopold Schmetterer,1,3 Guido Dorner,1 Gabriele Zanaschka,1 Christa Mensik1 & Hans-Georg Eichler1 1
2
3
Department of Clinical Pharmacology, Department of Medical Angiology, Institute of Medical Physics, Vienna University, Austria
Aims It has been suggested that provision of the substrate of nitric oxide (NO) synthesis, l-arginine, might influence the effects of renal vasoconstrictors. We have therefore studied the effects of pretreatment or concomitant administration of larginine on angiotensin II (ANG II)-increased renovascular resistance. Methods The study was conducted in a double-blind, randomized, cross-over design. Eight healthy subjects were assigned to placebo or a continuous intravenous coinfusion of ANG II (5.0 ng kg−1 min−1, infusion period 75 min) with l-arginine −1 −1 min , infusion period 30 min). Nine further subjects received a (17 mg kg continuous infusion of ANG II with or without pretreatment of l-arginine. Changes in renal plasma flow (RPF) were estimated by the steady state clearance of PAH. Results l-arginine alone increased RPF to 110±10% over baseline ( P
