Abstract. Background: Metastasis associated gene-1. (MTA1), was initially discovered in aggressive human cancer cell lines and has been subsequently ...
CANCER GENOMICS & PROTEOMICS 12: 113-118 (2015)
Expression of Metastasis-associated Gene-1 Is Associated With Bone Invasion and Tumor Stage in Human Pituitary Adenomas WANG JIA1,2,3,4, JINKUI ZHU1,6, TRACEY A. MARTIN2,3,4,5,7, ANDREW J. SANDERS2,3,4,5,7, XIAOMEI YANG2,4,5, SHAN CHENG2,4,5, HEFEN YU2,4,5, GUIJUN JIA1, XIAO LIU1, RUNCHUN LU1 and WEN G. JIANG2,3,4,5,7
1Department
of Neurosurgery, Beijing TianTan Hospital, Capital Medical University, Beijing, P.R. China; of Cancer, 3Brain Institute, 4Cardiff University–Capital Medical University Joint Centre for Biomedical Research and 5China–UK Cancer International Collaboration Base (Beijing), Capital Medical University, FengTai, Beijing, P.R. China; 6Department of Neurosurgery, ZhaoYuan RenMin Hospital, YanTai, Shandong, P.R. China; 7Cardiff University School of Medicine, Cardiff, U.K.
2Institute
Abstract. Background: Metastasis associated gene-1
(MTA1), was initially discovered in aggressive human cancer cell lines and has been subsequently associated with the invasiveness and metastatic potential of cancer cells. Materials and Methods: In the present study, we evaluated the expression levels of MTA1 in a cohort of human pituitary tumors (n=95) and examined the relationship between MTA1 expression and the pathological, clinical and aggressiveness of these tumors. Results: MTA1 was expressed at significantly higher levels in large tumors and in those with higher tumor grade. It was also observed that tumors that had invaded the suprasellar bones and tumors that destructed the sella had significantly higher levels than those without bone involvement (p
