Fenton's reagent

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molecule of hydrogen peroxide, forming a hydroperoxyl radical and a proton. The net effect is a disproportionation of hydrogen peroxide to create two different ...
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Fenton's reagent Fenton's reagent is a solution of hydrogen peroxide and an iron catalyst that is used to oxidize contaminants or waste waters. Fenton's reagent can be used to destroy organic compounds such as trichloroethylene (TCE) and polychloroethylene (PCE). It was developed in the 1890s by Henry John Horstman Fenton as an analytical reagent.[1] Iron(II) is oxidized by hydrogen peroxide to iron(III), forming a hydroxyl radical and a hydroxide ion in the process. Iron(III) is then reduced back to iron(II) by another molecule of hydrogen peroxide, forming a hydroperoxyl radical and a proton. The net effect is a disproportionation of hydrogen peroxide to create two different oxygen-radical species, with water (H+ + OH−) as a byproduct. (1) Fe2+ + H2O2 → Fe3+ + HO• + OH− (2) Fe3+ + H2O2 → Fe2+ + HOO• + H+ The free radicals generated by this process then engage in secondary reactions. For example, the hydroxyl is a powerful, non-selective oxidant. Oxidation of an organic compound by Fenton's reagent is rapid and exothermic and results in the oxidation of contaminants to primarily carbon dioxide and water.[2]

Reaction (1) was suggested by Haber and Weiss in the 1930s as part of what would become the Haber–Weiss reaction.[3] Iron(II) sulfate is typically used as the iron catalyst. The exact mechanisms of the redox cycle are uncertain, and non-OH• oxidizing mechanisms of organic compounds have also been suggested. Therefore, it may be appropriate to broadly discuss Fenton chemistry rather than a specific Fenton reaction. In the electro-Fenton process, hydrogen peroxide is produced in situ from the electrochemical reduction of oxygen.[4] Fenton's reagent is also used in organic synthesis for the hydroxylation of arenes in a radical substitution reaction such as the classical conversion of benzene into phenol. (3) C6H6 + FeSO4 + H2O2 → C6H5OH A recent hydroxylation example involves the oxidation of barbituric acid to alloxane.[5] Another application of the reagent in organic synthesis is in coupling reactions of alkanes. As an example tert-butanol is dimerized with Fenton's reagent and sulfuric acid to 2,5-dimethyl-2,5-hexanediol.[6]

Biomedical applications The Fenton reaction has importance in biology because it involves the creation of free radicals by chemicals that are present in vivo. Transition-metal ions such as iron and copper donate or accept free electrons via intracellular reactions and help in creating free radicals. Most intracellular iron is in ferric (+3 ion) form and must be reduced to theferrous (+2) form to take part in Fenton reaction. Since superoxide ions and transition metals act in a synergistic manner in the creation of free radical damage, iron supplementation must not be done in patients with any active infections or in general any diseases.[7]

Henry John Horstman Fenton (18 February 1854 – 13 January 1929) was a British chemist who, in the 1890s invented Fenton's reagent,[1] a solution of hydrogen peroxide and an iron catalyst that is used to oxidize contaminants or waste waters. Fenton's

reagent can be used to destroy organic compounds such as trichloroethylene (TCE) andtetrachloroethylene (PCE). Born in London, Henry Fenton was educated at Magdalen College School, King's College London and Christ's College, Cambridge.[2] He became the university demonstrator in Chemistry at Cambridge in 1878, and was University Lecturer in Chemistry from 1904 to 1924.

References: 1. Fenton H.J.H. (1894). "Oxidation of tartaric acid in presence of iron". J. Chem. Soc., Trans. 65 (65): 899–911. doi:10.1039/ct8946500899. 2. http://geocleanse.com/fentonsreagent.asp 3. Haber, F. and Weiss, J. (1932). "Über die Katalyse des Hydroperoxydes". Naturwissenschaften 20 (51): 948–950. doi:10.1007/BF0150471. 4. Juan Casado,Jordi Fornaguera,Maria I. Galan (January 2005). "Mineralization of Aromatics in Water by Sunlight-Assisted Electro-Fenton Technology in a Pilot Reactor". Environ. Sci. Technol. 39 (6): 1843– 47. doi:10.1021/es0498787. PMID 15819245. 5. Brömme HJ, Mörke W, Peschke E (November 2002). "Transformation of barbituric acid into alloxan by hydroxyl radicals: interaction with melatonin and with other hydroxyl radical scavengers". J. Pineal Res. 33 (4): 239–47. doi:10.1034/j.1600079X.2002.02936.x. PMID 12390507. 6. E. L. Jenner (1973). "α,α,α',α'-Tetramethyltetramethylene glycol". Org. Synth.; Coll. Vol. 5, p. 1026. 7. Robbins and Cotran (2008). Pathologic Basis of Disease - 7th edition. Elsevier. p. 16. ISBN 9780808923022. ----------------------------------------------------------------------------------------------------------------------------------------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------

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