Fig. S4 - PLOS

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Figure S4. TCF21, AHR, and ARNT co-expression moduls build a strong interconnected network of genes. Co-expression modules of TCF21 and AHR-ARNT ...
Fig. S4

ART3 SYT2

MYL3 HOXC10

NDRG4 FHOD3

CAND2 LINC00574

POPDC3 S100A1

SERPINB10

4104

TPTE MAGEA4

8352

MAGEA1

MAGEB2 MAGEA3

8343

OR12D3

8365

RBP4 8367

8332

CLTCL1

CDH18

AZGP1

26105

KLHL11

ALDH1A3

UCP2

IFI30

PYCARD

SPRY2

S100P

TCIRG1

CLEC2B

PTX3

DUSP5 NR4A2 BTG2

PHLDA1 CSTA

PDK2

MLXIP

SEMA3C

PRAME

FOSB VAV3 HIST1H2AC LGALS1 RGS2

IFITM2 IFI27

IL17RC

GPNMB 27099

PILRB150759 SLC27A6

CFH C3

ELK1

339457 TCEA2

RNASE4 CFD

F13A1

GPR137 GPA33

SENP7 PAPSS2

ITGA5

DUSP4 PLA2G4A

ID1 2575

ATF3

MT1M

FAM215A CRYAB AKR1C2

JUN

MAFB S100A8 S100A9

EGR2

GADD45B PPP1R15A

CCL19 TSPAN8

PCK1

CCL2

AKR1B10 HCAR3

NPY1R

3514 100130100

LXN AKR1C1

METRN

MAPK8IP1 MARCKSL1 LOC101928916

ENC1

PTRF

CCL21 FABP4 FBLN2

AOX1

SERPINF1

CD163

SERPING1 ADH1C

BTBD2 NME5 SLC2A10 RARRES1

SCUBE2 GPX3

TPSB2

DAAM2

NPIPA1 SALL2

PLIN1 ADIPOQ

IRX6

TPSAB1

DHRS2

MAGEC1 MAGEA12

TIMP4

GIPC2

GCM2

ADH1B

CHRDL1

RARRES2 CLEC3B PLA2G2A EMILIN1 C7 C1S AOC3 MFAP4 TCF21 IL33

AEBP1 GHR ADIRF LYVE1 TMEM100 F10 DPT ASPN

MGP

ELTD1 ADAMTS1 FXYD1 VSIG4

OGN

OLFML1 SPARCL1

AKR1C3 ZKSCAN1 MAFF FBLN5 MFAP5 THBS1 PLN WFDC1 PROS1 LUM ENPP2 SAT1 FOSL2 CPA3 BEX4 FOS PCP4 IGFBP3 COL6A2COL3A1 COL6A3 SGK1 DCN ZFP36 TIMP3 MYL9 C1R PTGS2 TIMP1 HAUS3 TSPYL4 PDGFRLPAMR1 COL15A1 IL1B IFITM1 NT5E SNAI2 CD55 FAM46A CXCL3 MIR22 CXCL12 S100A4 CD37 BHLHE40 CNN1 TSC2 SERPINE1 OLFML3 NID2 PLEKHF2 MTMR11CYR61 IL6 SRGN NLRP2 LOC100996809 COL5A1 DUSP6 CPE TAGLN PLXNB1 RXRB LMOD1 JUNB ADM CTGF CEBPB ZNF217 CXCL2 COL1A2 FAM129ASLC16A6 MXRA5COL1A1 CYP1B1 AMIGO2 FBN1 BBX SRPX TNFAIP3 DUSP1 EMP1 TGFBI FN1 PCOLCE COL5A2 GEM GBP2 MMP1 FHL1 AHNAK2 CASQ2 AHR LOC100506558COL4A1 LTBP4 RARRES3 SQRDL IL8 ACTG2 MYH11 ANXA4 TCN1 LGALS3 NFAT5 TGFB1I1 IGFBP6 LOC399491 EFEMP2 SLPITHBS2 COL4A2 MYLK CD44 TNFSF10 S100A6 FOXF1 MX1 IER3KLF4 DENND2D PSMB9 EGR1 G0S2 LTBP1 NCOA3 440350 OAS1 4065 EPS8 THBS3 NFKBIA ANXA1 TMEM45A DDX17 SERPINA3 GBP1 IGFBP4 ATXN7L3B FAM171A1 SPARC CAV1 SNRNP70 DDX60 57730 LHFP PALLD PLAU FBLN1 PRSS23 MVP MAP3K1 MYOF EGR3 PDGFC HLA-B FZD1 PLAT EMP3 EFEMP1 IL32 NR2F1 ELN PRPF39 TAP1 PLSCR4 AIM1 S100A11 TRIM22 RNFT1 OLFML2A IFI44L CAPG BIRC3 VCAN S100A10 GLT8D2 SMEK1 LOXL1 KRT5 IFI16 BASP1 NUMA1 ANXA2P2 TM7SF2 NAB2 CTSK FOXF2 HTRA1 MAN1A1 CXCR4 GBP3 ARNT ANXA2 MIR612 GOLGA8A LAMP3 WSB1 PLOD2 PMP22 KIAA1551 CHN1 LAMB2 CRIP2 100170939 KRT23 PPM1D PSMB8 ARHGEF17 RND3 DZIP1 BRIP1 FZD7 101929186 TNC DGKA VAMP8 CLK4 ISG20 CAV2 100127972 CLIP3 CD24 EZR 54145 FXYD5 LOC440895 PNMAL1 IRF6 SNAP23 TXNIP CNTNAP1 SYT11 BCL2A1TNFAIP8 RAC2 C6orf211 GUSBP3 MAP3K12 HIPK3 PNISR TRIB2 PXN GTF2H2B TP53 NXT2 MDK MFAP2 TRPC1 LY6E IL7R NAP1L3 PLEC GTF2I SP1 TNFRSF12A ISLR TAGLN2 SV2A MYH10 BAZ2B C1orf63 YOD1 CFI CD247 DNAJB4 PRAF2 80215 NEK9 ADAM10 ITGA6 HSPA6 TRIM25 ZBTB6 OR13C5 PIP5K1A CFHR1 UPP1 28755 TGFBR1 STXBP1 TMEM81 SERPINB2 MBNL2 RPL39L ENO2 PRUNE CLIC4 SMAGP CD164 11049 TRIM23 LMAN1 ITGA3 KLRC4-KLRK1 CDC42EP3 ID3 69 OR51F2 OR4X2 SCD GK3P HIST2H2BE CST7 ACER2 R3HCC1L FLNA SS18 STIP1 LMNB1 S100A2 LINC00341 LINC00339 DHX9 GNA13 SLC9A3R1 ATP10D EXOC5 ZBTB18 TMED2 ATP13A3 EIF4EBP1 MCM5 GMCL1 MYH9 COTL1 KCTD7 ARL2 TMOD3 ADAM15 DLG3 DACT1 CDC6 SH3BGRL3 KLHDC3 TCTEX1D2 PRICKLE3 PEX11B TNFAIP6 AP1S1 TMEM194A PFN1 IKBKB HIST2H2AC BTN3A2 PKP3 SLC2A3 ETS1 MCM4 ELL2 PRKAR2B CELSR2 CCNE2 ARHGDIA MSANTD3 USP21 PGM3 GBA VASP PSAT1 HIST2H4A TMEM158 HOXB2 SLFN12 SLC39A6 PLP2 GK PTPN11 SERINC5 GABPB2 IFIT1 CAPN7 FZD2 MISP EVI2A RAB38 ZBED2 S100A3 SBNO2 KRT6A KRT6B FOSL1 LYZ

BST2

NFIL3

CRIP1

CCL20

CXCL1

MALL

TFAP2A

Figure S4. TCF21, AHR, and ARNT co-expression moduls build a strong interconnected network of genes Co-expression modules of TCF21 and AHR-ARNT show a high degree of connectivity. TCF21, AHR and ARNT co-expression modules were defined using 4133 human RNA-seq datasets through GeneFriends and visualized with Cytoscape. Colored in different colors for AHR, ARNT and TCF21 are genes that represent direct partners, i.e. genes that are in the top 5% co-expressed genes.