(C-940) based gel formulations with the help of dispersion method for topical ap- ...... of a rapid HPLC method for simultaneous determination of tramadol, and its.
Flurbiprofen Loaded Gel Based Topical Delivery System: Formulation and In Vitro Characterization with New Developed UPLC Method A. Alper Öztürk1*, Umay Merve Güven2, Evrim Yenilmez1 1 Anadolu University, Faculty of Pharmacy, Department of Pharmaceutical Technology, Eskişehir, Turkey. 2 Çukurova University, Faculty of Pharmacy, Department of Pharmaceutical Technology, Adana, Turkey
ABSTRACT
Objective: The purpose of this study was to formulate flurbiprofen (FLB) loaded methylcellulose (MC), hydroxypropyl methylcellulose (HPMC) and Carbopol®940 (C-940) based gel formulations with the help of dispersion method for topical application. Additionally, in this study also a new ultra performance liquid chromatography method was developed for the determination of FLB, which was not previously entered into the literature. Method: FLB loaded gel formulations with the help of dispersion method for topical application and to characterize the formulations according to physical appearance, pH, rheology, drug content, dissolution study and release kinetic study with the DDSolver software program. The UPLC method developed was validated for linearity, specificity, precision, sensitivity, accuracy, range and robustness. Results: Linearity was determined to be at a concentration range of 5-50 µg.mL-1. The method developed for FLB was decided to be precise due to RSD values of
