Formic Acid - KAUST Repository

Coenzyme A (1XVT) PDB 3pmt 3ads 2o21 3mr2 2a5u 1fic 3k75 2xw1 1afo 2j14

RMSD 0.63 0.52 0.6 0.49 0.69 0.59 0.61 0.73 0.65 0.67

Seq 0.86 0.79 0.8 0.74 0.81 0.8 0.79 0.82 0.8 0.8

Distance Expression 0.45 0.02 0.48 0.01 0.5 0.03 0.52 0.01 0.54 0 0.51 0.04 0.53 0.02 0.51 0.04 0.53 0.02 0.52 0.03

Final 0.47 0.49 0.53 0.53 0.54 0.55 0.55 0.55 0.55 0.55

Gene Name Tudor domain-containing protein 3 Peroxisome proliferator-activated receptor gamma Apoptosis regulator Bcl-2 DNA polymerase eta Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform Fibrinogen gamma chain DNA polymerase beta, DNA repair protein XRCC1 Serum albumin Glycophorin-A Peroxisome proliferator-activated receptor delta

Terms Coenzyme A

CI 0 2.7824 1.56 0 0.975 0 0 0 0 2.5463

P-value Literature NA 0 0.002 6 0.007 2 NA 0 0.017 1 NA 0 NA 0 NA 0 NA 0 0.005 5

Formic Acid (1B93) PDB 3ipx 1nbq 1os4 1fls 1s3w 2o2m 3oq5 3km0 1t31 3koh

RMSD 0.62 0.67 0.63 0.65 0.59 0.66 0.54 0.64 0.61 0.65

Seq 0.86 0.83 0.82 0.83 0.84 0.84 0.8 0.81 0.8 0.81

Distance Expression 0.44 0.06 0.5 0.01 0.5 0.01 0.5 0.01 0.47 0.05 0.49 0.03 0.49 0.03 0.51 0.01 0.51 0.01 0.51 0.02

Final 0.5 0.51 0.51 0.51 0.52 0.52 0.52 0.52 0.52 0.53

Gene Name Deoxycytidine kinase Junctional adhesion molecule A Insulin Collagenase 3 Dihydrofolate reductase Bcl-2-like protein 1 Cellular tumor antigen p53 Estradiol 17-beta-dehydrogenase 1 Chymase Cytochrome P450 2E1

Terms Formic Acid

CI 0 0 0 0 0 0 1.5714 0 0 1.9864

P-value Literature NA 0 NA 0 NA 0 NA 0 NA 0 NA 0 0.002 2 NA 0 NA 0 0.001 3

Beta-D-glucose (1PIG) PDB 2qpj 3ant 3fxx 2g26 3ert 3eg9 2xm8 2q12 3nmd 3b2r

RMSD 0.69 0.55 0.54 0.62 0.65 0.66 0.58 0.63 0.62 0.69

Seq 0.9 0.83 0.81 0.86 0.82 0.8 0.82 0.79 0.79 0.79

Distance Expression 0.41 0.02 0.43 0.03 0.47 0.01 0.45 0.03 0.49 0.02 0.52 0.02 0.48 0.06 0.51 0.03 0.53 0.01 0.53 0.01

Final 0.43 0.46 0.48 0.48 0.51 0.54 0.54 0.54 0.54 0.54

Gene Name Neprilysin Bifunctional epoxide hydrolase 2 Ephrin type-A receptor 3 Renin Estrogen receptor Golgi SNAP receptor complex member 2 Serine/threonine-protein kinase Chk2 DCC-interacting protein 13-alpha cGMP-dependent protein kinase 1 cGMP-specific 3',5'-cyclic phosphodiesterase

Terms glucose

CI 2.3552 3.0992 0 3.5776 5.385 0 0 3.4707 4.6282 0.7702

P-value Literature 0.027 5 0.012 9 NA 0 0.004 13