Aug 9, 2008 - Chris M. G. Thomas, Ph.D.,a,b Paul N. Span, Ph.D.,a Jesper M. J. ... Rob G. J. M. Hanssen, Ph.D.,c Didi D. M. Braat, M.D., Ph.D.,b and Fred ...
Occurrence of postmenopausal-like acidic follicle-stimulating hormone (FSH) isoforms precedes the rise of FSH before menopause Chris M. G. Thomas, Ph.D.,a,b Paul N. Span, Ph.D.,a Jesper M. J. Smeenk, M.D., Ph.D.,b Rob G. J. M. Hanssen, Ph.D.,c Didi D. M. Braat, M.D., Ph.D.,b and Fred C. G. J. Sweep, Ph.D.a a Department of Chemical Endocrinology, and b Department of Obstetrics and Gynaecology, Radboud University Nijmegen Medical Centre, Nijmegen; and c N.V. Organon, Oss, The Netherlands
Objective: To assess the glycoform distribution patterns of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) during the menstrual cycle at different ages and FSH levels, after menopause, and with premature ovarian failure (POF). Design: Controlled clinical study. Setting: Healthy volunteers in an academic research environment. Patient(s): Women aged 20 to 25 years with normal early follicular (EF) serum FSH (40 IU/L and E2
