Jun 12, 2007 - We also thank Harold McClure, Stephanie. Ehnert, and the .... Kosub, E. Chacko, L. D. Giavedoni, C. C. Ibegbu, K. S. Cole, J. L. Miamidian,.
JOURNAL OF VIROLOGY, Feb. 2008, p. 1155–1165 0022-538X/08/$08.00⫹0 doi:10.1128/JVI.01275-07 Copyright © 2008, American Society for Microbiology. All Rights Reserved.
Vol. 82, No. 3
Gamma/Delta T-Cell Functional Responses Differ after Pathogenic Human Immunodeficiency Virus and Nonpathogenic Simian Immunodeficiency Virus Infections䌤 David A. Kosub,1 Ginger Lehrman,1 Jeffrey M. Milush,1† Dejiang Zhou,1‡ Elizabeth Chacko,1 Amanda Leone,1,2 Shari Gordon,3,4 Guido Silvestri,3 James G. Else,4 Philip Keiser,1 Mamta K. Jain,1 and Donald L. Sodora1,2* Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas1; Seattle Biomedical Research Institute, Seattle, Washington2; Department of Pathology, University of Pennsylvania, Philadelphia, Pennsylvania3; and Emory Vaccine Center and Yerkes National Primate Research Center, Emory University, Atlanta, Georgia4 Received 12 June 2007/Accepted 7 November 2007
The objective of this study was to functionally assess gamma/delta (␥␦) T cells following pathogenic human immunodeficiency virus (HIV) infection of humans and nonpathogenic simian immunodeficiency virus (SIV) infection of sooty mangabeys. ␥␦ T cells were obtained from peripheral blood samples from patients and sooty mangabeys that exhibited either a CD4-healthy (>200 CD4ⴙ T cells/l blood) or CD4-low (
