GAP JUNCTION UNCOUPLING AND DISCONTINUOUS ... - NCBI

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Jul 2, 1987 - A Comparison of Experimental Data with Computer Simulations. WILLIAM C. ..... recorded to floppy disc using an IBM XT computer and Computerscope. ISC- 16 ..... during washout and recovery from block in normal. Tyrodes ...

GAP JUNCTION UNCOUPLING AND DISCONTINUOUS PROPAGATION IN THE HEART A Comparison of Experimental Data with Computer Simulations WILLIAM C. COLE, JOHN B. PICONE, AND NICHOLAS SPERELAKIS Department ofPhysiology and Biophysics, University of Cincinnati College of Medicine, Cincinnati, OH 45267

ABSTRACT The effects of octanol on longitudinal propagation in guinea pig papillary muscles were measured by intracellular microelectrodes. These data were compared with alterations in conduction induced by stepwise removal of gap junction channels in computer simulations of propagation based on a discontinuous cable model. Octanol reduced the velocity (0) of propagating action potentials (APs) from 53.2 ± 3.5 to

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