Genetic Variations in Radiation and ... - Semantic Scholar

Genetic Variations in Radiation and Chemotherapy Drug Action Pathways and Survival in locoregionally Advanced Nasopharyngeal Carcinoma Treated with Chemoradiotherapy Huai Liu1,2☯, Bin Qi3☯, Xiang Guo1,2, Lin-Quan Tang1,2, Qiu-Yan Chen1,2, Lu Zhang1,2, Ling Guo1,2, Dong-Hua Luo1,2, Pei-Yu Huang1,2, Hao-Yuan Mo1,2, Yan-Qun Xiang1,2, Fang Qiu1,2, Rui Sun1,2, Ying Zhang1,4, MingYuan Chen1,2, Yi-Jun Hua1,2, Xing Lv1,2, Lin Wang1,2, Chong Zhao1,2, Ka-Jia Cao1,2, Chao-Nan Qian1,2, MingHuang Hong1,5, Hai-Qiang Mai1,2* 1 State Key Laboratory of Oncology in South China, Guangzhou, P. R. China, 2 Department of Nasopharyngeal Carcinoma, Sun Yat-sen University Cancer Center, Guangzhou, P. R. China, 3 Department of Radiotherapy, Affilated Tumor Hospital of Guangzhou Medical College, Guangzhou, P. R. China, 4 Tumor Resources Bank, Sun Yat-sen University Cancer Center, Guangzhou, P. R. China, 5 Department of Epidemiology, Clinical Trial Study Center, Sun Yat-sen University Cancer Center, Guangzhou, P. R. China

Abstract Background and Purpose: Treatment outcomes vary greatly in patients with nasopharyngeal carcinoma (NPC). The purpose of this study is to evaluate the influence of radiation and chemotherapy drug action pathway gene polymorphisms on the survival of patients with locoregionally advanced NPC treated with cisplatin- and fluorouracilbased chemoradiotherapy. Material and Methods: Four hundred twenty-one consecutive patients with locoregionally advanced NPC were prospectively recruited. We utilized a pathway approach and examined 18 polymorphisms in 13 major genes. Polymorphisms were detected using the LDR-PCR technique. Multifactor dimensionality reduction (MDR) analysis was performed to detect potential gene-gene interaction. Results: After adjustment for clinicopathological characteristics, overall survival was significantly decreased in patients with the MPO rs2243828 CT/CC genotype (HR=2.453, 95% CI, 1.687-3.566, P