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LSHB CT-2006-018661), the UK Myositis Support Group, Arthritis. Research UK (grant 18474), the Cure JM Foundation, the European. Science Foundation, the ...
ARTHRITIS & RHEUMATISM Vol. 65, No. 12, December 2013, pp 3239–3247 DOI 10.1002/art.38137 Published 2013. This article is a U.S. Government work and is in the public domain in the USA.

Genome-Wide Association Study of Dermatomyositis Reveals Genetic Overlap With Other Autoimmune Disorders Frederick W. Miller,1 Robert G. Cooper,2 Jiˇrí Vencovsky´,3 Lisa G. Rider,1 Katalin Danko,4 Lucy R. Wedderburn,5 Ingrid E. Lundberg,6 Lauren M. Pachman,7 Ann M. Reed,8 Steven R. Ytterberg,8 Leonid Padyukov,6 Albert Selva-O’Callaghan,9 Timothy R. D. J. Radstake,10 David A. Isenberg,5 Hector Chinoy,11 William E. R. Ollier,11 Terrance P. O’Hanlon,1 Bo Peng,12 Annette Lee,13 Janine A. Lamb,11 Wei Chen,12 Christopher I. Amos,12 and Peter K. Gregersen,13 with the Myositis Genetics Consortium Objective. To identify new genetic associations with juvenile and adult dermatomyositis (DM). Methods. We performed a genome-wide association study (GWAS) of adult and juvenile DM patients of European ancestry (n ⴝ 1,178) and controls (n ⴝ 4,724). To assess genetic overlap with other autoimmune disorders, we examined whether 141 singlenucleotide polymorphisms (SNPs) outside the major histocompatibility complex (MHC) locus, and previously associated with autoimmune diseases, predispose to DM.

Results. Compared to controls, patients with DM had a strong signal in the MHC region consisting of GWAS-level significance (P < 5 ⴛ 10–8) at 80 genotyped SNPs. An analysis of 141 non-MHC SNPs previously associated with autoimmune diseases showed that 3 SNPs linked with 3 genes were associated with DM, with a false discovery rate (FDR) of