Nov 3, 2015 - Dr. W. Eisenmenger (votum AZ 272-09). The study was performed in accordance with the institutional ethical guidelines and the German drug ...
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OPEN
received: 01 July 2015 accepted: 05 October 2015 Published: 03 November 2015
Glucocorticoid (dexamethasone)induced metabolome changes in healthy males suggest prediction of response and side effects Natalie Bordag1, Sebastian Klie2,†, Kathrin Jürchott3, Janine Vierheller3, Hajo Schiewe4, Valerie Albrecht5, Jörg-Christian Tonn5, Christoph Schwartz5, Christian Schichor5,* & Joachim Selbig3,* Glucocorticoids are indispensable anti-inflammatory and decongestant drugs with high prevalence of use at ~0.9% of the adult population. Better holistic insights into glucocorticoid-induced changes are crucial for effective use as concurrent medication and management of adverse effects. The profiles of 214 metabolites from plasma of 20 male healthy volunteers were recorded prior to and after ingestion of a single dose of 4 mg dexamethasone (+20 mg pantoprazole). Samples were drawn at three predefined time points per day: seven untreated (day 1 midday - day 3 midday) and four treated (day 3 evening - day 4 evening) per volunteer. Statistical analysis revealed tremendous impact of dexamethasone on the metabolome with 150 of 214 metabolites being significantly deregulated on at least one time point after treatment (ANOVA, Benjamini-Hochberg corrected, q
