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BMJ 2011;343:d3805 doi: 10.1136/bmj.d3805
Page 1 of 14
Research
RESEARCH Glycaemic control in type 1 diabetes during real time continuous glucose monitoring compared with self monitoring of blood glucose: meta-analysis of randomised controlled trials using individual patient data John C Pickup professor of diabetes and metabolism 1, Suzanne C Freeman medical statistics student 2 3, Alex J Sutton professor of medical statistics 2 1
Diabetes Research Group, Division of Diabetes and Nutritional Sciences, King’s College London School of Medicine, Guy’s Hospital, London SE1
1UL, UK; 2Department of Health Sciences, University of Leicester, Leicester, UK; 3MRC Clinical Trials Unit, London
Abstract Objective To determine the clinical effectiveness of real time continuous glucose monitoring compared with self monitoring of blood glucose in type 1 diabetes. Design Meta-analysis of randomised controlled trials. Data sources Cochrane database for randomised controlled trials, Ovid Medline, Embase, Google Scholar, lists of papers supplied by manufacturers of continuous glucose monitors, and cited literature in retrieved articles. Studies reviewed Randomised controlled trials of two or more months’ duration in men and non-pregnant women with type 1 diabetes that compared real time continuous glucose monitoring with self monitoring of blood glucose and where insulin delivery was the same in both arms. Analysis Two step meta-analysis of individual patient data with the primary outcome of final glycated haemoglobin (HbA1c) percentage and area under the curve of hypoglycaemia (glucose concentration
