RESEARCH ARTICLE
Glycemic Control and Mortality in Diabetic Patients Undergoing Dialysis Focusing on the Effects of Age and Dialysis Type: A Prospective Cohort Study in Korea Ji In Park1,2, Eunjin Bae2,3, Yong-Lim Kim2,4, Shin-Wook Kang2,5, Chul Woo Yang2,6, NamHo Kim2,7, Jung Pyo Lee2,8, Dong Ki Kim2,3, Kwon Wook Joo2,3, Yon Su Kim2,3, Hajeong Lee2,3*
OPEN ACCESS Citation: Park JI, Bae E, Kim Y-L, Kang S-W, Yang CW, Kim N-H, et al. (2015) Glycemic Control and Mortality in Diabetic Patients Undergoing Dialysis Focusing on the Effects of Age and Dialysis Type: A Prospective Cohort Study in Korea. PLoS ONE 10(8): e0136085. doi:10.1371/journal.pone.0136085 Editor: Xiaoying Wang, Massachusetts General Hospital, UNITED STATES Received: March 11, 2015 Accepted: July 29, 2015 Published: August 18, 2015 Copyright: © 2015 Park et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Data Availability Statement: All relevant data are within the paper and its Supporting Information files. Funding: This study was supported by a grant from the Korea Healthcare Technology R&D Project, Ministry of Health and Welfare, Republic of Korea (HI10C2020). Clinical research center for end-stage renal disease received the funding, and the leader of the center is YLK. The "Ministry of Health and Welfare" URL is: http://www.mw.go.kr/. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
1 Department of Internal Medicine, Kangwon National University College of Medicine, Chuncheon, Korea, 2 Clinical Research Center of End Stage Renal Disease in Korea, Daegu, Korea, 3 Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea, 4 Department of Internal Medicine, Kyungpook National University School of Medicine, Daegu, Korea, 5 Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea, 6 Department of Internal Medicine, The Catholic University of Korea College of Medicine, Seoul, Korea, 7 Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Korea, 8 Department of Internal Medicine, Seoul National University Boramae Medical Center, Seoul, Korea *
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Abstract Background Active glycemic control has been proven to delay the onset and slow the progression of diabetic retinopathy, nephropathy, and neuropathy in diabetic patients, but the optimal level is obscure in end-stage renal disease. In this study, we evaluated the effect of hemoglobin A1c (HbA1c) on mortality of diabetic patients on dialysis, focusing on age and dialysis type.
Methods Of 3,302 patients enrolled in the prospective cohort for end-stage renal disease in Korea between August 2008 and October 2013, 1,239 diabetic patients who had been diagnosed with diabetes or having HbA1c6.5% at the time of enrollment were analyzed. Age was categorized as
