After 14 days of incubation, all bone-marrow cell colonies were composed primarily of macrophages rather than granulocytes as had been previously reported. OHIO J. SCI. 76(6): 274 ... to form colonies of up to 2000 leukocytes. (Metcalf and ...
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Ohio Journal of Science (Ohio Academy of Science)
Ohio Journal of Science: Volume 76, Issue 6 (November, 1976)
1976-11
Granulocytic Colony Stimulating Activity in Plasma and Leukocytes from Chronic Myelogenous Leukemia Patients Patchen, Myra L.; Graham, James D. The Ohio Journal of Science. v76, n6 (November, 1976), 274-278 http://hdl.handle.net/1811/22409 Downloaded from the Knowledge Bank, The Ohio State University's institutional repository
GRANULOCYTIC COLONY STIMULATING ACTIVITY IN PLASMA AND LEUKOCYTES FROM CHRONIC MYELOGENOUS LEUKEMIA PATIENTS 1 MYRA L. PATCHEN 2 AND JAMES D. GRAHAM3, Leukemia Research Laboratory, Department of Biological Science, Bowling Green State University, Bowling Green, Ohio 43403
Abstract. Colony stimulating activity present in plasma and in leukocytes from chronic myelogenous leukemia patients and from normal volunteers was determined by double layer bone-marrow tissue culture. Plasma and leukocytes incorporated into the bottom feeder layer stimulated the formation of colonies from human bone-marrow cells cultured in the upper semi-solid agar layer. The colony stimulating activity of plasma from chronic myelogenous leukemia patients was significantly increased over that of normal plasma (p
