All the samples were run in Sysmex XN 1000 and the FCS data (WNR and WDF channel) were exported and analyzed. Results: On microscopy, among the ...
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INDEX Abstracts Selected for JC Patel Award Abstracts Selected for Oral Presentation
3 11 - 40
Day-1: Laboratory Category •
Acute Leukemia
12
•
Red Cell Disorders and Haemophilia
18
•
Bone Marrow Failure Syndromes and Infections
27
•
Stem Cell Transplant and Others
34
Day-2: Clinical Category
41 - 73
•
Acute Leukemia
42
•
Stem Cell Transplant
49
•
Lymphoma and Myeloma
57
•
Others
64
Abstracts Selected for Poster Presentation
75 - 226
Day 1 – Benign Haematology •
Disorders of Red Blood Cells
76
•
Bone Marrow Failure Syndromes
118
•
Disorders of Haemostasis
125
•
Disorders of White Blood Cells
156
•
Lab Haematology
162
•
Transfusion Medicine
183
•
Stem Cell Transplant
194
•
Others
207
Day 2– Malignant Haematology
227 - 395
•
Acute Lymphoblastic Leukemia
228
•
Acute Myeloid Leukemia Including Acute Promyelocytic Leukemia
250
•
Chronic Leukemia (Myeloid and Lymphoid)
290
•
Myeloproliferative Neoplasms
323
•
Lymphoma
333
•
Multiple Myeloma
360
•
Stem Cell Transplant
378
•
Others
387
ABSTRACTS SELECTED FOR JC PATEL AWARD
www.haematocon.in
3
ABSTRACT:
1
Image Analyzing Drying Patterns of Blood and Plasma Droplets for the Rapid Detection of Thalassaemia Carriers 1
2
1*
Manikuntala Mukhopadhyay , Rudra Ray , Maitreyee Bhattacharyya , Sunando Das Gupta
2*
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Aims & Objective: 7KHELUWKRIWKDODVVDHPLFFKLOGUHQFDQRQO\EHSUHYHQWHGE\DYRLGLQJPDUULDJHVEHWZHHQWZR FDUULHUV7KXVWKHPDMRUFKDOOHQJHLQDSSURDFKLQJಫ]HURWKDODVVHPLDಬQDWLRQLVWRVFUHHQWKHHQWLUHSRSXODWLRQXQGHU WKHUHSURGXFWLYHDJHJURXS$UDSLGSRUWDEOHDQGDXWRPDWHGWHFKQRORJ\IRUಫRQᚏHOGಬVFUHHQLQJRIWKDODVVDHPLDFDU ULHUVIRUERWKUXUDODQGXUEDQPDVVSRSXODWLRQLVKHQFHRISULRULPSRUWDQFH7KHREMHFWLYHRIWKLVVWXG\ZDVWRGHWHFW WKHWKDODVVDHPLDFDUULHUVEDVHGRQWKHLPDJHSDWWHUQDQDO\VLVE\GU\LQJEORRGSODVPDGURSOHWVRQJODVVVXEVWUDWHV DQGWRLGHQWLI\WKHGLVWLQFWVLJQDWRU\IHDWXUHVLQWKHSDWWHUQVIURPWKHUHVSHFWLYHVDPSOHV Method: )LIW\VDPSOHVIURPWKUHHJURXSVL+HDOWK\LL%HWDFDUULHULLL+E(&DUULHUZHUHFROOHFWHGIRUWKHEORRG SODVPDGURSOHWGU\LQJSDWWHUQDQDO\VLV'URSOHWVRIZKROHEORRG SODVPDZHUHDOORZHGWRGU\QDWXUDOO\DWURRPWHP SHUDWXUHRQWKHFOHDQHGJODVVVXEVWUDWHV7KHᚏQDOGULHGSDWWHUQZDVREVHUYHGXQGHUDQRSWLFDOPLFURVFRSH /(,&$ '0/00 LQWUDQVPLVVLRQPRGHZLWK[PDJQLᚏFDWLRQ7KHKLJKTXDOLW\LPDJHVZHUHDQDO\]HGLQ,PDJH-VRIW ZDUH Y SODWIRUP Result: 7KHGU\LQJSDWWHUQVRIKHDOWK\EORRG SODVPDVDPSOHVZDVGLVWLQFWO\GLᚎHUHQWWKDQWKDWRIWKHFDUULHUVDP SOHV,WZDVSRVVLEOHWRVFUHHQWKHKHDOWK\DQGFDUULHUVDPSOHVE\VLPSOHYLVXDOL]DWLRQWKHPLFURVFRSLFLPDJHVLWVHOI 7KHFUDFNVREWDLQHGLQWKHGULHGSDWWHUQVRIWKHKHDOWK\VDPSOHVZHUHUHPDUNDEO\ORQJHUDVFRPSDUHGWRWKHFDUULHU VDPSOHV$VLJQLᚏFDQWLQFUHDVHLQWKHQXPEHURIWKHUDGLDOFUDFNVZDVDOVRREVHUYHGIRUWKHFDUULHUVDPSOHV7KHVH GU\LQJSDWWHUQVZHUHIRXQGWREHLQGHSHQGHQWRIWLPHDQGWKHGURSOHWYROXPH
Conclusion: 7KHSUHVHQWVWXG\KDVFRQFOXVLYHO\SURYHGWKDWGLVWLQFWSDWWHUQVDUHREVHUYHGRQGU\LQJZKROHEORRG GURSOHWVDQGSODVPDRQJODVVIRUERWKWKHFDUULHUDQGWKHKHDOWK\VDPSOHV7KHVHSDWWHUQVFDQEHIXUWKHUXWLOL]HGWR FUHDWHDGDWDEDQNIRUDXWRPDWHGFODVVLᚏFDWLRQRIWKHXQNQRZQVDPSOHVZKLFKZLOOVHUYHDVDIDFLOHPHWKRGIRUWKH UDSLGDQGPDVVVFUHHQLQJRIWKHWKDODVVDHPLDFDUULHUV
4
www.haematocon.in
ABSTRACT: 2 A Next Generation Sequencing Based Approach to Elucidate the Clinical and Genetic Spectrum of Uncommon Congenital Anemias
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www.haematocon.in
5
ABSTRACT: 3 Expression of Programmed cell Death Ligand1 (PDL1) and Programmed cell Death1 (PD1) in Patients with Diffuse Large B cell Lymphoma (DLBCL): An Indian Study Mukesh Chawla*1, Sujan K Dhar2, Biswajeeta Saha3, Malini Venkata4, Manjula Das5, Manjunatha Nayak3, Sharat Damodar1, Shobha Badiger6, Sunil Bhat6, Bharath Ram1, Shilpa Prabhu1, Karuna Kumar1, Hamza Dalal1, Nataraj K S1 1Department of Haematology, Narayana Health City, 2Sankhya Sciences, 3Biocon-BMS Research Centre, Syngene International Ltd, 4Bristol Myers Squibb, 5Tumor Immunology Group, Mazumdar Shaw Centre for Translational Research, MSMF, 6Department of Paediatric Hemato-oncology, Narayana Health City, Bangalore, India
Introduction:%ORFNDGHRIWKH3'3'/SDWKZD\PD\KDYHVLJQLᚏFDQWSRWHQWLDOIRUDQWLWXPRUHᚎHFWVLQ'/%&/ Aims and Objectives: 7RVWXG\WKHLQFLGHQFHRI3'/ 3'H[SUHVVLRQDQGLWVDVVRFLDWLRQZLWKFOLQLFDOFKDUDFWHU LVWLFVPHGLDQHYHQWIUHHVXUYLYDO ()6 DQGRYHUDOOVXUYLYDO 26 LQSDWLHQWVZLWK'/%&/ Materials & Methods:$UHWURVSHFWLYHREVHUYDWLRQDOVWXG\ZLWKSURVSHFWLYHIROORZXSDW1DUD\DQD+HDOWK&LW\%DQ JDORUHRISDWLHQWV))3(EORFNVRIWXPRXUWLVVXHVZHUHLPPXQRVWDLQHGIRU3'/DQG3'&XWRᚎIRU3'/ZDV WDNHQDVุDQG3'ZDVH[SUHVVHGDVKLJKORZYDOXHVIURPWKHPHGLDQ6WDWLVWLFDODQDO\VLVZDVFDUULHGRXWXVLQJ 5VRIWZDUHYHUVLRQ.DSODQದ0HLHUPHWKRGZLWKORJUDQNWHVWZDVXVHGIRUVXUYLYDODQDO\VLV&R[SURSRUWLRQDO KD]DUGVPRGHOZDVXVHGIRUXQLYDULDWHDQGPXOWLYDULDWHDQDO\VLV Results: 7KHPHGLDQDJHZDV\HDUV \HDUV 0DOH IHPDOHUDWLRZDV KDG*&%DQGKDG $%& VXEW\SH $W ODVW IROORZ XS RI VXEMHFWV ZHUH DOLYH DQG KDG GLHG ,QFLGHQFH RI 3'/ H[SUHVVLRQ LV Q 7KHPHGLDQIROORZXSZDVPRQWKV7KHPHGLDQ()6GXUDWLRQZDV PRQWKVDQG26GXUDWLRQZDV PRQWKV7KHUHZDVDVLJQLᚏFDQWGLᚎHUHQFHLQPHGLDQ()6DQG26GXUDWLRQZLWKUHVSHFWWRWKHSUHVHQFHRIFR PRUELGLWLHV S DQG+DQVVXEW\SH S S 1RVWDWLVWLFDOO\VLJQLᚏFDQWDVVRFLDWLRQZDVIRXQG EHWZHHQ3'/DQG3'VWDWXVZLWKUHVSHFWWRFOLQLFDOFKDUDFWHULVWLFV+DQVVXEW\SHVWDJLQJULVNVFRULQJUHVSRQVH DQGUHODSVHUDWHV()6DQG2626WHQGWREHEHWWHULQ3'7,/VKLJKJURXSWKDQ3'7,/VORZJURXSWKRXJK VWDWLVWLFDOO\RIZHDNVLJQLᚏFDQFH S 3UHVHQFHRIFRPRUELGLW\+DQVVXEW\SHDQG5,3,VFRUHZHUHLQGHSHQGHQW ULVNIDFWRUVIRUERWK()6DQG26LQPXOWLYDULDWHDQDO\VLV+RZHYHU3'/DQG3'ZHUHQRWIRXQGWREHLQGHSHQGHQW ULVNIDFWRUV Conclusion:26WHQGWRKDYHDEHWWHUDVVRFLDWLRQZLWKKLJK3'H[SUHVVLRQDQGQRW3'/H[SUHVVLRQ3'/3' EORFNDJHPLJKWEHDSRWHQWLDOWKHUDSHXWLFWDUJHW Keywords:SURJUDPPHGFHOOGHDWKOLJDQGSURJUDPPHGFHOOGHDWKGLᚎXVHODUJH%FHOOO\PSKRPD+DQVVXEW\SH HYHQWIUHHVXUYLYDORYHUDOOVXUYLYDO
6
www.haematocon.in
ABSTRACT: 4
Utility of Single Tube 10-Color Flow Cytometry Screening Panel in the Diagnosis of Myelodysplastic Syndrome 5LFKD&KDXKDQ +33DWL$QLWD&KRSUD0DQRUDQMDQ0DKDSDWUD
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www.haematocon.in
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www.haematocon.in
ABSTRACT: 5
A study to compare Haematopoietic Progenitor Cell (HPC) determined on the 6\VPH[;1 ZLWKÀRZF\WRPHWULF&'FRXQWLQSHULSKHUDOEORRGDQGLQWKH harvested peripheral blood stem cell graft from autologous and allogenic donors. 6KUXWL0LVKUD-R\-0DPPHQ%LMX*HRUJH6XNHVK&K1DLU8GD\.XONDUQL 1LWW\0DWWKHZVDQG5DP\D9
1. 'HSDUWPHQWRI7UDQVIXVLRQ0HGLFLQHDQG,PPXQRKHPDWRORJ\ 2. 'HSDUWPHQWRI&OLQLFDO+HPDWRORJ\ 3. &KULVWLDQ0HGLFDO&ROOHJHDQG+RVSLWDO9HOORUH Introduction and Background: +HPDWRSRLHWLF VWHP FHOO WUDQVSODQWDWLRQ LV WKH FXUUHQW VWDQGDUG RI FXUDWLYH FDUH IRUDOOKHPDWRO\PSKRLGPDOLJQDQFLHVDVZHOODVRIPDQ\QRQPDOLJQDQWFRQGLWLRQVOLNHPDUURZIDLOXUHV\QGURPHV LQERUQ HUURUV RI PHWDEROLVP DQG LPPXQHGHᚏFLHQF\ V\QGURPHV $ VXFFHVVIXO ERQH PDUURZ WUDQVSODQW UHTXLUHV D PLQLPXPRI[AFHOOVNJSDWLHQWERG\ZHLJKWRI&'FHOOVLQWKHSURGXFWEHLQJWUDQVIXVHG&'FHOO FRXQWLQWKHSHULSKHUDOEORRGKDVWKHEHVWSUHGLFWLYHYDOXHIRUWKHVWHPFHOO\LHOGLQWKHDSKHUHVLVEDJ7KHPDMRU GLVDGYDQWDJHVRIWKLVDUHWKHWXUQDURXQGWLPHDQGWKHFRVWEHVLGHVUHTXLULQJVSHFLDOL]HGᚐRZF\WRPHWULFDQDO\VLV HTXLSPHQWDQGWUDLQHGRSHUDWRUV+3& +HPWRSRLHWLF3URJHQLWRU&HOOV LVDSDUDPHWHUZKLFKLVPHDVXUHGE\DXWR PDWHGSODWIRUPVRI6\VPH[;1VHULHV Aims and Objectives:7KLVVWXG\DLPHGWRᚏQGWKHUHOLDELOLW\RI+3&GHWHUPLQHGRQWKH6\VPH[;1 LQFRPSDU LVRQZLWKᚐRZF\WRPHWULF&'FRXQWLQSHULSKHUDOEORRGDQGLQWKHKDUYHVWHGSHULSKHUDOEORRGVWHPFHOOJUDIWIURP DXWRORJRXVDQGDOORJHQLFGRQRUV Materials and Methods: DXWRORJRXVDQGDOORJHQHLFGRQRUVZHUHHQUROOHGLQRXUVWXG\DIWHUGXHFRQVHQW7/& 7RWDO/HXNRF\WH&RXQW 01& 0RQRQXFOHDUFHOOFRXQW +3& &'DVVD\ZHUHGRQHLQERWKWKHSHULSKHUDOEORRG SULRU WR DSKHUHVLV DQG WKH KDUYHVW SURGXFW SRVWDSKHUHVLV 6\VPH[;1 ZDV XVHG IRU 7/& 01& DQG +3& DVVD\6OLGHVZHUHVWDLQHGE\DXWRPDWHGVOLGHUVWDLQHUDQGHYDOXDWHGE\WKHLQYHVWLJDWRU&'$VVD\ZDVGRQHLQ ᚐRZF\WRPHWHUXVLQJ,6+$*(VLQJOHSODWIRUPSURWRFRO6WDWLVWLFDODQDO\VLVZDVGRQHXVLQJ6366 Discussion and Conclusion:DOORJHQLFDQGDXWRORJRXVGRQRUVZHUHHQUROOHGZHUHIHPDOHVDQG PDOHV&RUUHODWLRQEHWZHHQ+3&DQG&'ZDVIRXQGWREHZLWKSYDOXH LQSHULSKHUDOEORRGDQG ZLWKSYDOXH LQWKHKDUYHVWSURGXFW2QWKHRWKHUKDQG7/&KDGDFRUUHODWLRQRIDQGLQSHULSKHUDO EORRGDQGKDUYHVWUHVSHFWLYHO\01&KDGDSRRUFRUUHODWLRQZLWKSRRUVWDWLVWLFDOVLJQLᚏFDQFH6RZHFRQFOXGHWKDW +3&LVFRPSDUDEOHWR&'LQSUHGLFWLQJKDUYHVWSURGXFWಬVDGHTXDF\
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9
ABSTRACT: 6
'RQRUO\PSKRF\WHLQIXVLRQLQFKLOGUHQHI¿FDF\LQSUHYHQWLQJJUDIWUHMHFWLRQDQG relapse - experience from a tertiary referral centre in southern India 9HQNDWHVZDUDQ960HHQD66KLYDQL3.HVDYDQ051LNLOD5DP\D8/DNVKPDQDQ95HYDWKL5 'HSDUWPHQWRI3HGLDWULF+HPDWRORJ\2QFRORJ\DQG%ORRGDQG0DUURZ7UDQVSODQWDWLRQ $SROOR&DQFHU,QVWLWXWHV7H\QDPSHW&KHQQDL7DPLOQDGX,QGLD
Background: 'RQRUO\PSKRF\WHLQIXVLRQ '/, LVDIRUPRIFHOOXODULPPXQRWKHUDS\,QPDOLJQDQFLHVLWPD\EHHᚎHF WLYHLQSUHYHQWLQJDUHODSVHGXHWRJUDIWYHUVXVOHXNDHPLDHᚎHFWDQGLQEHQLJQKHPDWRORJLFDOFRQGLWLRQVLWKHOSVSUH YHQWWKHSURJUHVVLRQRILPSHQGLQJJUDIWUHMHFWLRQ7KHUHLVVFDQWGDWDIRUWKHXVHRI'/,LQFKLOGUHQDQGZHGHVFULEH WKHLQGLFDWLRQVDQGFRVWHᚎHFWLYHPHWKRGVRIGHOLYHULQJFDUHDWRXUFHQWUH Patients and methods: :HFRQGXFWHGDUHWURVSHFWLYHDQDO\VLVRIWKHFKLOGUHQZKRXQGHUZHQWKHPDWRSHLWLFVWHP FHOOWUDQVSODQWDWLRQDQGUHFHLYHGGRQRUO\PSKRF\WHLQIXVLRQHLWKHUDVDSDUWRISUHHPSWLYHWKHUDS\LQOHXNDHPLDRU IRUPL[HGFKLPHULVPLQEHQLJQGLVRUGHUVDW$SROOR&DQFHU,QVWLWXWHVIURPWKH\HDU-DQXDU\WR0D\7KH ᚏUVWVWHSZDVZLWKGUDZDORILPPXQRVXSSUHVVLRQDQG'/,ZDVFRPPHQFHGGD\VODWHULIWKHUHZDVQRHYLGHQFHRI JUDIWYHUVXVKRVWGLVHDVH7KHGHVLUHGYROXPHRIIUHVKSHULSKHUDOEORRGIURPWKHGRQRUZDVLQIXVHGEDVHGRQWKH &'FRXQW'RQRUO\PSKRF\WHLQIXVLRQZDVJLYHQLQDJUDGHGUHJLPHQZLWKWKHFHOOGRVHRI[ &'FHOOVNJ [ F'FHOOVNJ[ &'FHOOVNJGHSHQGLQJRQWKHJUDIWNLQHWLFVDQGWKHFOLQLFDOVWDWXVRIWKHFKLOGUHQ7KH GRVHZDVRQHORJORZHULQFKLOGUHQXQGHUJRLQJKDSORLGHQWLFDO+6&7VWDUWLQJDW[ NJ Results: $WRWDORI FKLOGUHQXQGHUZHQW+6&7GXULQJWKHVWXG\SHULRGDQG'/,ZDVSHUIRUPHGLQᚏIW\VHYHQFKLO GUHQ7KHPDOHIHPDOHUDWLRZDV DQGZHUHIRUEHQLJQKDHPDWRORJLFDOFRQGLWLRQVLQFOXGLQJWKDODVVDHPLD PDMRUVLFNOHFHOODQDHPLDDQGSULPDU\LPPXQHGHᚏ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onclusion: 'RQRUO\PSKRF\WHLQIXVLRQLVDQHᚎHFWLYHWRROLQFKLOGUHQDQGKHOSVSUHYHQWJUDIWUHMHFWLRQLQEHQLJQ FRQGLWLRQVDQGUHODSVHRIOHXNHPLDLQKLJKULVNFDVHV,WLVDVDIHSURFHGXUHIRUWKHGRQRUDVWKHJUDGHGUHJLPHQ UHTXLUHGYHU\VPDOODPRXQWVRISHULSKHUDOEORRGIURPPOWRPO&DUHIXOIROORZXSRIJUDIWNLQHWLFVDQGFOLQLFDO YLJLODQFHIRUJUDGHJUDIWYHUVXVKRVWGLVHDVHPDNHVLWDQHDVLO\DSSOLFDEOHWRROHYHQLQUHVRXUFHFRQVWUDLQHGVHW WLQJVDQGLQKDSORLGHQWLFDO+6&7
Keywords: 'RQRUO\PSKRF\WHLQIXVLRQJUDIWNLQHWLFVPL[HGFKLPHULVPSUHHPSWLYHWKHUDS\*9+'
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ABSTRACTS SELECTED FOR ORAL PRESENTATION DAY-1: LABORATORY CATEGORY
www.haematocon.in
11
Acute Leukemia HAEMATOCON2018-387
IMMUNOPHENOTYPIC ASSESSMENT OF MINIMAL RESIDUAL DISEASE IN YOUNGER ACUTE MYELOID LEUKEMIA PATIENTS IS HIGHLY PREDICTIVE OF OUTCOME &KLQPD\HH1.DNLUGH 6LWDUDP*KRJDOH0DQMX6HQJDU+DVPXNK-DLQ%KDXVDKHE%DJDO 3UDVKDQW7HPEKDUH3*6XEUDPDQLDQ6XPHHW*XMUDO1DYLQ.KDWWU\1LNKLO3DWNDU +HPDWRSDWKRORJ\/DE$&75(&7DWD0HPRULDO+RVSLWDO1DYL0XPEDL$GXOW+HPDWR2QFRORJ\7DWD0HPRULDO +RVSLWDO0XPEDL,QGLD
Aims & Objectives:*RDORIFKHPRWKHUDS\LQDFXWHP\HORLGOHXNHPLD $0/ LVWRDFKLHYHPRUSKRORJLFDOUHPLVVLRQ +RZHYHUQRWDOOSDWLHQWVDFKLHYHORQJWHUPUHPLVVLRQDQGVXEVHWRISDWLHQWVಬUHODSVH'HWHFWLRQRIPLQLPDOUHVLGXDO GLVHDVH 05' IROORZLQJ FKHPRWKHUDS\ LV KLJKO\ SUHGLFWLYH RI RXWFRPH DQG DOORZV WUHDWPHQW PRGLᚏFDWLRQV LI UHTXLUHG+HUHZHGHVFULEHDVVHVVPHQWRILPPXQRSKHQRW\SLF05'XVLQJDFRPELQDWLRQRIGLᚎHUHQFHIURPQRUPDO DQGOHXNHPLDDVVRFLDWHGLPPXQRSKHQRW\SH /$,3 DSSURDFKLQSDWLHQWVRIDGXOW$0/ Patients/Materials & Methods: :H DFFUXHG SDWLHQWV RI DGXOW $0/ RWKHU WKDQ ZLWK W RYHU PRQWK VW-XO\VW'HFHPEHU DIWHUREWDLQLQJLQIRUPHGFRQVHQWSDWLHQWVZHUHSURFHVVHGXVLQJWXEH FRORXUDVVD\DQGSDWLHQWVZHUHSURFHVVHGXVLQJWXEHFRORXUDVVD\,GHQWLFDOSDQHOZDVXVHGDWEDVHOLQH SRVWLQGXFWLRQ 3, DQGSRVWFRQVROLGDWLRQ 3& WLPHSRLQWVHYHQWVZHUHDFTXLUHGSHUWXEHZLWKWKHWXEH DVVD\DQGPLOOLRQHYHQWVSHUWXEHREWDLQHGSHUWXEHZLWKWKHWXEHDVVD\$QDO\VLVZDVGRQHXVLQJ.DOX]D E\DFRPELQDWLRQRIGLᚎHUHQFHIURPQRUPDODSSURDFKWKDWIRFXVHGRQWKHGHYHORSPHQWRIP\HORLGSURJHQLWRUV WRPDWXUHFHOOVDQG/$,3DSSURDFKHV&\WRJHQHWLFVWXGLHVE\FRQYHQWLRQDONDU\RW\SLQJDQG),6+ZDVGRQHDVSHU 1&&1 UHFRPPHQGDWLRQV3DWLHQWVZHUHFODVVLᚏHGLQWRIDYRXUDEOHLQWHUPHGLDWHDQGSRRUF\WRJHQHWLFULVN 7KHSUHVHQFHRI)/7,7'130DQG&(%3$PXWDWLRQVZDVGHWHFWHGE\IUDJPHQWOHQJWKDQDO\VLVEDVHGDVVD\ 5HVXOWVZHUHDQDO\VHGIRULPSDFWRQ2YHUDOOVXUYLYDO 26 DQG5HODSVHIUHHVXUYLYDO 5)6 XVLQJORJUDQNWHVW Results: 7KHPHGLDQDJHRIHQWLUHFRKRUWZDV\HDUV%DVHGRQF\WRJHQHWLFVDQGSDWLHQWV ZHUH FODVVLᚏ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ದ @IROORZHGE\SRRUF\WRJHQHWLFULVN> S +5 &, WR @ Discussion & Conclusion: 2XU GDWD GHPRQVWUDWHV WKDW 05' E\ ᚐRZ F\WRPHWU\ DW HQG RI LQGXFWLRQ DV ZHOO DV FRQVROLGDWLRQ DUH LPSRUWDQW SURJQRVWLF IDFWRUV WRJHWKHU ZLWK NQRZQ IDFWRUV VXFK DV KLJKULVN F\WRJHQHWLFV $0/ 05'LVDYHU\XVHIXOJXLGHIRUSRVWUHPLVVLRQVWUDWHJLHVLQ$0/DQGVKRXOGEHLQFRUSRUDWHGLQWRURXWLQHWUHDWPHQW DOJRULWKPV Disclosure of Interest:1RQH'HFODUHG Keywords: $FXWH0\HORLG/HXNHPLD,PPXQRSKHQRW\SLQJ0LQLPDO5HVLGXDO'LVHDVH
12
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HAEMATOCON2018-299
INCIDENCE AND PROGNOSTIC IMPLICATION OF TP53 DELETION IN DE NOVO ADULT ACUTE MYELOID LEUKEMIA +HPDQL-DLQ 'KDQOD[PL6KHWW\0DQMX6HQJDU+DVPXNK-DLQ%KDXVDKHE%DJDO1DYLQ.KDWWU\ $YLQDVK%RQGD6DFKLQ3XQDWDU$QDQW*RNDUQ1LNKLO3DWNDU &DQFHU&\WRJHQHWLF'HSDUWPHQW$GYDQFHG&HQWUHIRU7UHDWPHQW5HVHDUFKDQG(GXFDWLRQLQ&DQFHU $&75(& 7DWD0HPRULDO&HQWUH1DYL080%$,0HGLFDO2QFRORJ\7DWD0HPRULDO+RVSLWDO0XPEDL0HGLFDO2QFRORJ\ $GYDQFHG&HQWUHIRU7UHDWPHQW5HVHDUFKDQG(GXFDWLRQLQ&DQFHU $&75(& 7DWD0HPRULDO&HQWUH0HGLFDO 2QFRORJ\7DWD0HPRULDO+RVSLWDO+HPDWRSDWKRORJ\'HSDUWPHQW$GYDQFHG&HQWUHIRU7UHDWPHQW5HVHDUFKDQG (GXFDWLRQLQ&DQFHU $&75(& 7DWD0HPRULDO&HQWUH1DYL080%$,,QGLD
Aims & Objectives: 73LVDWXPRXUVXSSUHVVRUJHQHSUHVHQWRQFKURPRVRPHSDQGLWVORVVLVDVVRFLDWHG ZLWKGLVHDVHSURJUHVVLRQDQGGLVPDORXWFRPH2XUDLPZDVWRGHWHUPLQHWKHIUHTXHQF\RI73GHOHWLRQLQ$0/ UHVSRQVHWRWUHDWPHQWDQGLWVFRUUHODWLRQZLWKRWKHUJHQHWLFFKDQJHV Patients/Materials & Methods: 5HWURVSHFWLYH),6+DQGFRQYHQWLRQDONDU\RW\SLQJVWXGLHVZHUHFDUULHGRXWLQ DGXOW$0/SDWLHQWV PDOHVIHPDOHV $JHUDQJH \HDUV GLDJQRVHGIURP2FWREHUWR'HFHPEHU ),6+ SUREHV ZHUH XVHG WR GHWHFW UHFXUUHQW F\WRJHQHWLF DEHUUDWLRQV W W T LQY PRQRVRP\ GHO T PRQRVRP\GHO T WULVRP\DQGGHO S 6WDWLVWLFDODQDO\VLVZDVFDUULHGRXWXVLQJFKLVTXDUHDQG 0DQQ:KLWQH\ 8 WHVW WR FKHFN DVVRFLDWLRQ EHWZHHQ 73 GHOHWLRQ ZLWK DJH JHQGHU F\WRJHQHWLF DEQRUPDOLWLHV PXWDWLRQVRI130)/7&(%3$KDHPRJORELQ:%&DQGSODWHOHWFRXQWV 5HVXOWV ,QWHUSKDVH),6+ UHYHDOHG 73 GHOHWLRQ LQ SDWLHQWV 73 GHOHWLRQ SRVLWLYH SDWLHQWV ZHUH \RXQJ DGXOWV 3 DQG KDG ORZHU :%& FRXQW 3 VLJQLᚏFDQWO\ DVVRFLDWHG ZLWK KLJK ULVN F\WRJHQHWLF DEHUUDWLRQV PRQRVRP\GHO T 3 PRQRVRP\GHO T 3 FRH[LVWHQWGHO T DQGGHO T 3 DQGWULVRP\ 3 73GHOHWLRQSRVLWLYHSDWLHQWVZHUHQHJDWLYHIRUW DQGLQY 1RVWDWLVWLFDO GLᚎHUHQFHVZHUHIRXQGIRU130)/7,7'DQG&(%3$PXWDWLRQV73GHOHWLRQSRVLWLYHSDWLHQWVKDGFRPSOH[ NDU\RW\SHV Discussion & Conclusion:,QRXUVWXG\73GHOHWLRQLQFLGHQFHZDVORZHUDVFRPSDUHGWROLWHUDWXUH ZDVIRXQGLQ \RXQJDGXOWVKDYLQJORZ:%&FRXQWVZDVDVVRFLDWHGZLWKKLJKULVNF\WRJHQHWLFPDUNHUVKDGFRPSOH[NDU\RW\SHV DQGSRRURUQRUHVSRQVHWRVWDQGDUGFKHPRWKHUDS\73GHOHWLRQVKRXOGEHDQDO\]HGDORQJZLWKRWKHUF\WRJHQHWLF PDUNHUVWRULVNVWUDWLI\SDWLHQWVDQGSODQDSSURSULDWHWKHUDS\IRUEHWWHUPDQDJHPHQWRIWKHSDWLHQW Disclosure of Interest: 1RQH'HFODUHG Keywords: DFXWHP\HORLGOHXNHPLD73GHOHWLRQSURJQRVLV
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13
HAEMATOCON2018-360
ULTRADEEP NEXT GENERATION SEQUENCING (NGS) BASED MEASURABLE RESIDUAL DISEASE (MRD) ASSESSMENT IN NPM1 MUTATED ACUTE MYELOID LEUKEMIA (AML) IS THE MOST IMPORTANT PREDICTOR OF OUTCOME 3UDVDQQD%KDQVKH 1LNKLO3DWNDU5RKDQ.RGJXOH+DVPXNK-DLQ%KDXVDKHE%DJDO0DQMX 6DQJDU1DYLQ.KDWWU\3DSDJXGL6XEUDPDQLDQ6XPHHW*XMUDO6LWDUDP*KRJKDOH
+HPDWRSDWKRORJ\$GXOW+HPDWRORJ\3DWKRORJ\7DWD0HPRULDO&HQWUH1HZ0XPEDL,QGLD
Aims & Objectives:6HULDOPRQLWRULQJRI130PXWDWLRQVIURPWKHEORRGRUERQHPDUURZXVLQJPXWDWLRQVSHFLᚏF DVVD\VGXULQJFKHPRWKHUDS\RI$0/ZLWKPXWDWHG130 130PXW$0/ KDVEHHQVKRZQWREHKLJKO\SUHGLFWLYH RI UHODSVH '1$ EDVHG 1*6 LV D SURPLVLQJ VFDODEOH VROXWLRQ WKDW KDV WKH SRWHQWLDO WR GHWHFW 05' LQ $0/ :H GHPRQVWUDWHWKDWXOWUDGHHS1*6EDVHG05' 1*605' LVLQGHSHQGHQWO\SUHGLFWLYHRIRXWFRPHIRU130PXW$0/ Patients/Materials & Methods: :H DQDO\VHG WKH FOLQLFDO VLJQLᚏFDQFH RI PRQLWRULQJ 05' XVLQJ XOWUDGHHS 1*6 1*605' DQGᚐRZF\WRPHWU\ )&005' LQVDPSOHVREWDLQHGIURPSDWLHQWVRI130PXW$0/DWWKHHQG RILQGXFWLRQ 3, DQGFRQVROLGDWLRQ 3& ([RQRI130JHQH ZKHUH! RIDOO130PXWDWLRQVRFFXU ZDV 3&5DPSOLᚏHGXVLQJDGDSWRUOLQNHGSULPHUVDQG'1$DVDWHPSODWH6DPSOHVZHUHGHHSVHTXHQFHGRQ,OOXPLQD 0L6HT ,OOXPLQD XVLQJYSDLUHGHQGFKHPLVWU\7KHOLEUDU\ZDVVHTXHQFHGDWPRUHWKDQ[FRYHUDJH WRKDYHDVHQVLWLYLW\RI)RU)&005'PLQLPXPRIPLOOLRQHYHQWVZHUHDFTXLUHGSHUWXEHRQD1DYLRV ᚐRZF\WRPHWHU,GHQWLFDOSDQHOZDVXVHGDW05'WLPHSRLQWVDVZHOODVRQWKHGLDJQRVWLFVDPSOH$QDO\VLVRI)&0 05'ZDVGRQHXVLQJ.DOX]DE\DGLᚎHUHQFHIURPQRUPDODSSURDFK%DVHGRQUHFHLYHURSHUDWLQJFKDUDFWHULVWLF 52& DQG &, @ DQGZDVVLJQLᚏ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isclosure of Interest:1RQH'HFODUHG Keywords: 0HDVXUDEOHUHVLGXDOGLVHDVH 05' 1H[WJHQHUDWLRQVHTXHQFLQJ130PXWDWHG$0/
14
www.haematocon.in
HAEMATOCON2018-374
NUP98-NSD1 GENE REARRANGEMENT IN ACUTE MYELOID LEUKEMIA (AML)REPORT OF TWO CASES DETECTED BY TARGETED RNA SEQUENCING 6KUXWL5*KDL *RXWKDP5DYDO5RKDQ.RGJXOH3UDVDQQD%KDQVKH6KUXWL&KRXGKDU\6ZDSQDOL -RVKL3UDVKDQW7HPEKDUH6XPHHW*XMUDO3DSDJXGL6XEUDPDQLDQ1LNKLO3DWNDU
+HPDWRSDWKRORJ\7$7$0HPRULDO+RVSLWDO0XPEDL,QGLD
Aims & Objectives: 7KH183 16'LVDF\WRJHQHWLFDOO\FU\SWLFWUDQVORFDWLRQRIWHQDVVRFLDWHGZLWKWKH)/7,7' PXWDWHG$0/LQWKH\RXQJZLWKSRRUSURJQRVLV&\WRJHQHWLFWHFKQLTXHVVXFKDV),6+KDYHOLPLWDWLRQVLQLGHQWLᚏFDWLRQ RIFU\SWLFJHQHIXVLRQVDVLWLVDQXQUHOLDEOHDVVD\LQLGHQWLI\LQJIXVLQJJHQHDVZHOODVWKHLUH[DFWJHQHVHTXHQFHV +HUHZHGHVFULEHWZRFDVHVRI$0/ZLWKUDUH183 16'IXVLRQGHWHFWHGXVLQJLQH[SHQVLYHODERUDWRU\GHYHORSHG WDUJHWHG51$VHTXHQFLQJIRUWKHGHWHFWLRQRIXQNQRZQIXVLRQVZKHUHRQHSDUWQHULVNQRZQ Patients/Materials & Methods: $V D SDUW RI $0/ ZRUNXS ODERUDWRU\ GHYHORSHG DVVD\ ZDV SHUIRUPHG RQ ERWK VDPSOHVWKDWGHWHFWIXVLRQVXVLQJWDUJHWHG51$VHTXHQFLQJDVZHOODVVRPDWLFPXWDWLRQVRQJHQRPLF'1$'RXEOH VWUDQGHGF'1$ZDVV\QWKHVL]HGDQGWKHQIUDJPHQWHG$WDLOHGDQGOLJDWHGXVLQJKDOIIXQFWLRQDOVHTXHQFLQJPRWLIV $JHQHP\HORLGSDQHOZDVGHVLJQHGVRDVWRGHWHFWDQ\SUHVXPHGSDUWQHURIDIXVLRQJHQHZKHUHRQHRIWKH SDUWQHUVLVNQRZQ$QDO\VLVRI)$674ᚏOHVRIIXVLRQDVVD\ZDVGRQHXVLQJ67$5)XVLRQ)XVLRQ&DWFKHUDQG)XVLRQ ,QVSHFWRU 7DUJHWHG '1$ VHTXHQFLQJ ZDV DOVR GRQH LQ WKHVH FDVHV WR GHWHFW PXWDWLRQV LQ JHQHV FRPPRQO\ LPSOLFDWHGLQSDWKRJHQHVLVRIP\HORLGPDOLJQDQFLHV Results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iscussion & Conclusion: $VSHFLᚏ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isclosure of Interest:1RQH'HFODUHG Keywords:$0/1*6183 16'
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15
HAEMATOCON2018-372
A LABORATORY DEVELOPED TARGETED RNA SEQUENCING ASSAY FOR IDENTIFICATION OF FUSION GENES IN BCR-ABL1 LIKE PRECURSOR B LINEAGE ACUTE LYMPHOBLASTIC LEUKEMIA (BCR-ABL1 LIKE BCPALL) $QDP)6KDLNK *RXWKDP5DYDO5RKDQ.RGJXOH6KUXWL&KRXGKDU\6ZDSQDOL-RVKL3UDVDQQD %KDQVKH3UDVKDQW7HPEKDUH3DSDJXGL6XEUDPDQLDQ6XPHHW*XMUDO1LNKLO3DWNDU
+HPDWRSDWKRORJ\7DWD0HPRULDO+RVSLWDO0XPEDL,QGLD
Aims & Objectives: %&5$%/ OLNH %&3$// LV D ELRORJLFDOO\ KHWHURJHQHRXV GLVRUGHU FKDUDFWHULVHG E\ KLJK SUHYDOHQFHRI ! RIJHQHIXVLRQVDQGSRWHQWLDOWKHUDSHXWLFUHOHYDQFH&RQYHQWLRQDOWHFKQLTXHVVXFKDV),6+ DUHQRWVXLWDEOHDVGLDJQRVWLFVWUDWHJLHVDVWKH\FDQQHLWKHUFRQVLVWHQWO\LGHQWLI\ERWKSDUWQHUVLQYROYHGLQDJHQH IXVLRQQRUFDQWKH\LGHQWLI\WKHH[DFWJHQHVHTXHQFHVIRUPRQLWRULQJSXUSRVHV+HUHZHGHVFULEHDQRYHOORZFRVW ODERUDWRU\GHYHORSHG51$VHTXHQFLQJDVVD\IRULGHQWLᚏFDWLRQRIXQNQRZQNLQDVHIXVLRQVLQ%&5$%/OLNH%&3$// Patients/Materials & Methods:'RXEOHVWUDQGHGF'1$ZDVV\QWKHVL]HGDQGWKHQIUDJPHQWHG$WDLOHGDQGOLJDWHG XVLQJKDOIIXQFWLRQDOVHTXHQFLQJPRWLIV:HGHVLJQHGWKHSDQHO (%)(325)*)5,.=)127&+183 35)&@DQG GRZQUHJXODWLRQRI$UDFPHWDEROLVPJHQHVOLNH'&.>)&@33$5*>)&@ Discussion & Conclusion: 2XUUHVXOWVVXJJHVWWKDWVLPLODUJHQHH[SUHVVLRQVLJQDWXUHWRWKDWREVHUYHGLQSULPDU\ $0/FHOOVSOD\VUROHHYHQLQWKHDFTXLUHG$UD&UHVLVWDQFH+RZHYHUWKHPHFKDQLVWLFUROHRIWKHVHDGGLWLRQDOWDUJHWV LQPHGLDWLQJ$UD&UHVLVWDQFHQHHGWREHYDOLGDWHGLQWKLVPRGHO Keywords: $FXWH0\HORLG/HXNHPLDDFTXLUHGUHVLVWDQFH
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HAEMATOCON2018-421
GRAFT VERSUS HOST DISEASE MANIFESTATION : IMPACT OF IMMUNOMODULATORY FACTORS - HLA-G EXPRESSION, TH1/TH2 CYTOKINES AND TREG CELL FREQUENCY 8PD.DQJD 0DQLVK0RXU\D7XOLND6HWK.DXVWDY&KRZGKXU\'LSHQGUD.0LWUD3RRQDP&RVKLF 0DQRUDQMDQ0DKSDWUD 7UDQVSODQW,PPXQRORJ\DQG,PXQRJHQHWLFV+HPDWRORJ\7UDQVIXVLRQ0HGLFLQH$OO,QGLD,QVWLWXWHRI0HGLFDO 6FLHQFHV1HZ'HOKL,QGLD
Aims & Objectives: +/$* LV D QRQFODVVLFDO +/$FODVV , PROHFXOH ZLWK NQRZQ LPPXQRPRGXODWRU\ SURSHUWLHV 7KHಬ875LPSDFWV+/$*H[SUHVVLRQDVPL51$VLQWHUDFWZLWKSRO\PRUSKLFVLWHVLQWKLVUHJLRQDQGFRQWUROSRVW WUDQVFULSWLRQDO UHJXODWLRQ +/$* LQWHUDFWV ZLWK UHFHSWRUV ,/7 ,/7 DQG .,5'/ RQ &' &' DQG 1. FHOOV 7KHKLJK+/$*H[SUHVVLQJ'&FHOOVVXEVHWLQGXFHDGDSWLYH,/SURGXFLQJ7UFHOOGLᚎHUHQWLDWLRQYLDWKH,/ GHSHQGHQW +/$*,/7 SDWKZD\ DQG PHGLDWH D WROHURJHQLF PLFURHQYLURQPHQW 3UHVHQW VWXG\ ZDV SODQQHG WR HYDOXDWH+/$*H[SUHVVLRQLWVFRUUHODWLRQZLWKSRVW+6&77UHJFHOOIUHTXHQF\DQGF\WRNLQHPLOHXWRXQGHUWVQDGWKH SRVVLEOHLPSDFWRQDOORLPPXQHUHVSRQVHDQGWUDQVSODQWRXWFRPH Patients/Materials & Methods: $SODVWLF $QHPLD DQG OHXNDHPLD SDWLHQWV XQGHUJRLQJ +HPDWRSRLHWLF 6WHP &HOO 7UDQVSODQWDWLRQ +6&7 ZHUHHQUROOHGIRUWKLVVWXG\3RO\PRUSKLVPLQ+/$*ಬ875^H[RQES,1'(/VDQG 613V PL51$LQWHUDFWLRQVLWHV `ZDVLQYHVWLJDWHG7UHJFHOOIUHTXHQF\OHYHOVRIV+/$*7K ,/,/71)˞ ,)1˨ DQG7KF\WRNLQHV /,/ ZHUHHYDOXDWHGLQ+6&7UHFLSLHQWVDWSUHDQGSRVWWUDQVSODQWWLPHSRLQWV GD\V DW*Y+' KHDOWK\FRQWUROVZHUHHQUROOHGWRHYDOXDWHSRSXODWLRQVSHFLᚏFFRUUHODWLRQEHWZHHQ 875KDSORW\SHVDQGV+/$*OHYHOV Results: $PRQJFRQWUROVESLQVLQVJHQRW\SHFRUUHODWHGZLWKKLJKHUV+/$*OHYHOV,QFLGHQFHRI*Y+'ZDVORZHU LQUHFLSLHQWVZLWKESLQVLQVJHQRW\SHFRPSDUHGWRWKRVHZLWKESGHOGHOJHQRW\SH+LJKHULQFLGHQFHRI*Y+' ZDVREVHUYHGDPRQJUHFLSLHQWVZLWKಬ875613JHQRW\SHV&&DQG&&6HYHQ875KDSORW\SHVZHUH REVHUYHGLQ1RUWK,QGLDQV*Y+'PDQLIHVWDWLRQZDVKLJKHULQUHFLSLHQWVFDUU\LQJORZV+/$*SURGXFLQJ875DQG 875 KDSORW\SHV 7UHJ FHOO IUHTXHQF\ OLQHDUO\ FRUUHODWHG ZLWK V+/$* OHYHOV 7KH 7UHJ FHOO IUHTXHQF\ OHYHOV RI V+/$**DQG7KF\WRNLQHVZHUHVLJQLᚏFDQWO\ORZHUDWWKHWLPHRI*Y+'ZKHUHDVOHYHOVRI7KF\WRNLQHVZHUH KLJKHU7UHJIUHTXHQF\DQGV+/$*OHYHOVLPSURYHGSRVW*Y+'WUHDWPHQW Discussion & Conclusion: +/$*ಬ875SRO\PRUSKLVPLPSDFWVV+/$*OHYHOVWKDWFUHDWHDQLPPXQRVXSSUHVVLYH PLFURHQYLURQPHQW PRGXODWH 7UHJ FHOO IUHTXHQF\ DQG 7K7K F\WRNLQH EDODQFH ZKLFK FRUUHODWHV ZLWK *Y+' PDQLIHVWDWLRQWKDWLQᚐXHQFHVWUDQVSODQWRXWFRPH+/$*FRXOGEHSURSRVHGDVDSRVVLEOHELRPDUNHUIRUSUHGLFWLQJ *Y+' Keywords: *Y+'+/$*7K7KF\WRNLQHV
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HAEMATOCON2018-332
CYTOGENETIC PROFILE OF PLASMA CELL NEOPLASM (PCN) PATIENTS USING FISH ANALYSIS OF CD138 POSITIVELY SELECTED PLASMA CELLS: TMC EXPERIENCE 7DQYL*XSWD 6XPDQWD3DWHO1HHUDM$URUD'HHSDN0LVKUD-HHYDQ.XPDU6DXUDEK%KDYH9LYHN 5DGKDNULVKQDQ5HHQD1DLU0DPPHQ&KDQG\0D\XU3DULKDU
&\WRJHQHWLFV+HPDWRORJ\&OLQLFDO+HPDWRORJ\7DWD0HGLFDO&HQWHU.RONDWD.RONDWD,QGLD
Aims & Objectives: 3UHWUHDWPHQWF\WRJHQHWLFULVNVWUDWLᚏFDWLRQLVDQLQWHJUDOSDUWRIPRGHUQWUHDWPHQWSURWRFROV LQ 3ODVPD FHOO QHRSODVPV 3&1 7KH F\WRJHQHWLF ULVN VWUDWLᚏFDWLRQ LQ 3&1 LQFOXGHV ,J+ JHQH UHDUUDQJHPHQWV WULVRPLHV GHOHWLRQ RI VKRUW DUP RI FKURPRVRPH DQG DQG DPSOLᚏFDWLRQ RI ORQJ DUP RI FKURPRVRPH :H SUHVHQWWKHF\WRJHQHWLFSURᚏOHRIDOOQHZO\GLDJQRVHG3&1SDWLHQWV Patients/Materials & Methods: 3&1SDWLHQWVZHUHGLDJQRVHGDW7DWD0HGLFDO&HQWHU.RONDWDIURP)HEUXDU\ -XO\ ,QWHUSKDVH ),6+ ZDV SHUIRUPHG RQ SRVLWLYHO\ VHOHFWHG &' SODVPD FHOOV (DV\6HSറ 67(0&(//റ7HFKQRORJLHV 7KH PLQLPXP SDQHO IRU ),6+ DQDO\VLV LQFOXGHG 73 GHOHWLRQ SUREH =\WRYLVLRQ *HUPDQ\ DQG ,J+ EUHDN DSDUW SUREH =\WRYLVLRQ LQFOXGLQJ W W DQG W GXDO FRORU GXDO IXVLRQ SUREHV9\VLV $GGLWLRQDOO\ ),6+ DQDO\VLVIRUK\SHUGLSORLG\ JDLQVRI DQG DQGFKURPRVRPHUHODWHGDEQRUPDOLWLHV SGHOHWLRQTDPSOLᚏFDWLRQ SUREHV 0HWDV\VWHPV*HUPDQ\ ZHUHVWXGLHGLQDVXEVHWRISDWLHQWV Results: RISDWLHQWV PHGLDQDJH\HDUVUDQJH VKRZHGFKURPRVRPDODEQRUPDOLWLHVZLWK KDYLQJ WZR RU PRUH DEHUUDWLRQV 7KH PHGLDQ SHUFHQWDJH RI SODVPD FHOOV ZDV ZLWK D UDQJH RI IRU DOO DEQRUPDOLWLHV ,J+JHQHUHDUUDQJHPHQWVZHUHVHHQLQ RISDWLHQWVZLWKW EHHQWKHPRVWIUHTXHQW IROORZHGE\W :HGLGQRWREVHUYHW LQDQ\RIRXUSDWLHQWV1R,J+SDUWQHUFRXOGEH LGHQWLᚏHG LQ ,J+ UHDUUDQJHG SDWLHQWV S ZDV REVHUYHG LQ RI FDVHV +\SHUGLSORLG\ ZDV HYLGHQWLQ FDVHV&KURPRVRPHUHODWHGDEQRUPDOLWLHVZHUHGHWHFWHGLQFDVHV ZLWK SUHVHQFHRISGHOHWLRQDQGTJDLQLQDQGSDWLHQWVUHVSHFWLYHO\ FDVHVZHUHFODVVLᚏHG DVKLJKULVNKDUERULQJHLWKHUSDQGRUSGHOHWLRQ SDWLHQWVIHOOXQGHULQWHUPHGLDWHULVNZKLOHUHVW ZHUHVWDQGDUGULVN 3DWLHQWVFDUU\LQJSRUFKURPRVRPHDEQRUPDOLWLHVVKRZHGKLJKHUWXPRUEXUGHQLQWHUPVRISHUFHQWDJHRI SODVPDFHOOVLQERQHPDUURZ Discussion & Conclusion: 7KH F\WRJHQHWLF DEQRUPDOLWLHV LQ WKH SUHVHQW VWXG\ GLVSOD\HG FRPDSDUDEOH LQFLGHQFH DV UHSRUWHG LQ SUHYLRXV VWXGLHV :H UHSRUW KLJKHU LQFLGHQFH RI K\SHUGLSORLG\ YV S YV DQG FKURPRVRPH DEHUUDWLRQV YV DQG ORZHU RFFXUHQFH RI ,J+ UHDUUDQJHPHQWV YV LQRXUSDWLHQWVFRPSDUHGWRRWKHU,QGLDQVWXGLHV Disclosure of Interest:1RQH'HFODUHG Keywords:&\WRJHQHWLFV),6+3ODVPDFHOOQHRSODVP
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HAEMATOCON2018-525
BCR-ABL KINASE DOMAIN MUTATION ANALYSIS BY NEXT GENERATION SEQUENCING DETECTED ADDITIONAL MUTATIONS IN CHRONIC MYELOID LEUKEMIA PATIENTS WITH SUBOPTIMAL RESPONSE TO IMATINIB (VWKHU6DWK\D%DPD%HQMDPLQ%KDUDWKL056HQWKDPL]KVHOYL$$E\$EUDKDP%LMX*HRUJH $ORN6ULYDVWDYD9LNUDP0DWKHZV3RRQNX]KDOL%DODVXEUDPDQLDQ
'HSDUWPHQW2I+DHPDWRORJ\&KULVWLDQ0HGLFDO&ROOHJH9HOORUH,QGLD
Background and Aim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ethods: 3HULSKHUDO EORRG VDPSOHV IURP &0/ SDWLHQWV Q ZKR GLG QRW DFKLHYH 0DMRU PROHFXODU UHVSRQVH 005 DWPRQWKVಬSRVWLPDWLQLEWKHUDS\ ,PDWLQLEVXERSWLPDOUHVSRQGHUV EXWZHUHQHJDWLYHIRU%&5$%/.' PXWDWLRQDQDO\VLVE\66ZHUHWHVWHGXVLQJ1*6 6RYHULQLHWDO :HDOVRLQFOXGHGWKUHHSDWLHQWVZLWKGHWHFWDEOH PXWDWLRQVE\66IRUDQDO\VLVE\1*6 Results:2YHUDOOSDWLHQWVZHUHIRXQGWRKDUERUPXWDWLRQVLQWKH%&5$%/.'E\1*61*6DOVRGHWHFWHG PXWDWLRQV WKDW KDV EHHQ SUHYLRXVO\ LGHQWLᚏHG E\ 66 IUDPHVKLIW GHOHWLRQ FBGHO LQVHUWLRQ .LQV4 FBLQV&$* DQG7,, DV) 9 S @DQGEDVHOLQH8$ PJ GO>S @SDWLHQWVRQDOORSXULQROGHYHORSHGODE7/6FRPSDUHGWRSDWLHQWVRQIHEX[RVWDW>S @7KH2GGV UDWLRIRU7/6LQSDWLHQWVUHFHLYLQJIHEX[RVWDWZDVOHVVHUDVFRPSDUHGWRWKRVHUHFHLYLQJDOORSXULQRO>25 @ $GYHUVH HYHQWV ZHUH QRWHG LQ Q PRVW FRPPRQ JDVWURLQWHVWLQDO LQ DOORSXULQRO JURXSLQ FRQWUDVW WR Q PRVW FRPPRQ WUDQVDPLQLWLV LQ WKH IHEX[RVWDW JURXS>S @&XWDQHRXV UHDFWLRQV Q ZHUH REVHUYHGRQO\LQDOORSXULQROJURXS ,PDJH
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'LVFXVVLRQ &RQFOXVLRQ )HEX[RVWDWZDVQRQLQIHULRUZLWKUHVSHFWWRLWV8$ORZHULQJHᚑFDF\LUUHVSHFWLYHRIW\SH RIOHXNHPLDEDVHOLQH/'+8$OHYHOVRUULVNFDWHJRU\RI7/6$OWKRXJKQRQVLJQLᚏFDQWIHEX[RVWDWKDGUHODWLYHO\OHV VHUULVNRI7/6ZLWKDWUHQGWRZDUGVOHVVHUWR[LFLW\ Disclosure of Interest 1RQH'HFODUHG Keywords:$OORSXULQRO)HEX[RVWDW8ULFDFLG
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HAEMATOCON2018-549
MANAGEMENT OF RELAPSE IN ACUTE PROMYELOCYTIC LEUKEMIA TREATED WITH UPFRONT ARSENIC TRIOXIDE BASED REGIMENS )RX]LD1D $QX.RUXOD9LEKRU6KDUPD7KHQPR]KL0DQL-H\DVHHODQ/DNVKPDQDQ$ORN 6ULYDVWDYD$E\$EUDKDP3RRQNX]KDOL%DODVXEUDPDQLDQ%LMX*HRUJH9LNUDP0DWKHZV
&OLQLFDO+DHPDWRORJ\%LRVWDWLVWLFV&KULVWLDQ0HGLFDO&ROOHJH9HOORUH9HOORUH,QGLD
Aims & Objectives: 7KH VWDQGDUG RI FDUH IRU SDWLHQWV ZLWK DFXWH SURP\HORF\WLFOHXNHPLD $3/ UHODSVLQJ DIWHU IURQWOLQHWUHDWPHQWZLWKDUVHQLFWULR[LGH $72 EDVHGUHJLPHQVUHPDLQVWREHGHᚏQHG:HSUHVHQWRXUH[SHULHQFH RQPDQDJHPHQWRIUHODSVHLQ$3/SDWLHQWVWUHDWHGZLWKIURQWOLQH$72EDVHGWKHUDS\ Patients/Materials & Methods:'DWDRQDOOFRQVHFXWLYHSDWLHQWVZLWKUHODSVHG$3/GLDJQRVHGDQGWUHDWHGLQWKH 'HSDWPHQWRI+DHPDWRORJ\&KULVWLDQ0HGLFDO&ROOHJH9HOORUHIURP-DQXDU\ ದ'HFHPEHUZHUHLQFOXGHG LQWKLVUHWURVSHFWLYHDQDO\VLV Results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sDQGs7KH\HDUHVWLPDWHRI26DQG()6RIWKRVH ZKRUHFHLYHGDXWRORJRXV6&7YVWKRVHZKRZHUHRQFKHPRWKHUDS\ZHUH sYVs 3 DQG sYVs 3 UHVSHFWLYHO\,QXQDGMXVWHGDQDO\VLVWKRVHZKRUHFHLYHGFKHPRWKHUDS\ DVSRVWUHODSVHFRQVROLGDWLRQKDG &, ದ WLPHVULVNRIUHODSVHDVFRPSDUHGWRWKRVHZKRUHFHLYHG DXWRORJRXV6&7 3 ,QWKHDGMXVWHGDQDO\VLVWKRVHZKRUHFHLYHGFKHPRWKHUDS\ZHUHQRWHGWRKDYHQHDUO\ WLPHV &, ದ ULVNRIUHODSVHDVFRPSDUHGWRWKRVHZKRUHFHLYHGDXWRORJRXV6&7 3 DIWHUDGMXV WLQJIRUDJHWRWDO:%&DWUHODSVHDQGGXUDWLRQRI&5 ,PDJH
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45
'LVFXVVLRQ &RQFOXVLRQ 5HPLVVLRQLQGXFWLRQZLWK$72EDVHGUHJLPHQVIROORZHGE\DQDXWRORJRXV6&7LQSDWLHQWV ZLWKUHODSVHG$3/ZKRZHUHWUHDWHGZLWKIURQWOLQH$72EDVHGUHJLPHQVLVDVVRFLDWHGZLWKH[FHOOHQWORQJWHUPVXUYL YDODQGVKRXOGEHFRQVLGHUHGWKHVWDQGDUGRIFDUHHYHQLQWKLVVHWWLQJ Disclosure of Interest:1RQH'HFODUHG Keywords DFXWHSURPH\ORF\WLFOHXNHPLD $3/ $UVHQLFWULR[LGH $72 $OOWUDQVUHWLQRLFDFLG $75$
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HAEMATOCON2018-431
AML INDUCTION MORTALITY AND OUTCOMES: 10 YEAR EXPERIENCE FROM A TERTIARY CANCER CENTRE IN INDIA +HPDQWK.XPDU 1LNLWD0HKUD3UDVDQWK*DQHVDQ9HQNDWUDPDQ5DGKDNULVKQDQ0DQLNDQGDQ 'KDQXVKNRGL7ULYDGL6*DQHVDQ.ULVKQDNXPDU.DQQDQ3.-D\DFKDQGUDQ.UXSD6KDQNDU 7HQDOL6DJDU 0HGLFDO2QFRORJ\&DQFHU,QVWLWXWH&KHQQDL&KHQQDL0HGLFDO2QFRORJ\-DZDKDUODO,QVWLWXWHRI3RVWJUDGXDWH 0HGLFDO(GXFDWLRQDQG5HVHDUFK -,30(5 3XGXFKHUU\,QGLD
Aims & Objectives: 7KHWUHDWPHQWRIDFXWHP\HORLGOHXNDHPLD $0/ ZLWKLQWHQVLYHLQGXFWLRQUHPDLQVDFKDOOHQJH (DUO\LQGXFWLRQUHODWHGGHDWKVSDUWLFXODUO\GXHWRLQIHFWLRXVFRPSOLFDWLRQVDUHDPDMRUSUREOHP,QWKLVVWXG\ZHDV VHVVLQGXFWLRQPRUWDOLW\LQDGXOW$0/SDWLHQWVZKRUHFHLYHGLQWHQVLYHLQGXFWLRQWKHUDS\LQDWHUWLDU\FDQFHUFHQWUHLQ ,QGLDRYHUD\HDUSHULRG Patients/Materials & Methods: 1HZO\GLDJQRVHGDGXOW$0/ !\HDUVQRQ0 WUHDWHGDW&DQFHU,QVWLWXWH&KHQ QDLZKRUHFHLYHGLQWHQVLYHLQGXFWLRQWKHUDS\ZHUHLQFOXGHGLQWKHVWXG\,QWHQVLYHWKHUDS\ZDVGHᚏQHGDVXVHRIDQ\ DQWKUDF\FOLQHZLWKF\WDUDELQH RWKHUV :HDVVHVVHGEDVHOLQHGHPRJUDSKLFVDQGNH\FOLQLFDORXWFRPHVLQFOX GLQJLQGXFWLRQPRUWDOLW\HYHQWIUHHVXUYLYDODQGRYHUDOOVXUYLYDO,QGXFWLRQPRUWDOLW\ZDVGHᚏQHGDVGHDWKVRFFXUULQJ ZLWKLQGD\VRILQLWLDWLQJWUHDWPHQWIRU$0/RUVWDUWRIQGLQGXFWLRQ Results: %HWZHHQ -DQXDU\ DQG 'HFHPEHU SDWLHQWV ZLWK $0/ ZHUH HYDOXDWHG DQG DFFHSWHG IRU WUHDWPHQW([FOXGLQJ SDWLHQWVZKRZHUHXQᚏWIRULQWHQVLYHLQGXFWLRQ SDWLHQWVUHFHLYHGWUHDWPHQWDQGZHUH LQFOXGHGLQWKHDQDO\VLV 0HGLDQDJHZDV\HDUVDQG ZHUHPDOHSDWLHQWV SDWLHQWVUHFHLYHGWKHVWDQGDUG LQGXFWLRQ RIWKHFDVHVKDGLQIHFWLRQDWWKHWLPHRISUHVHQWDWLRQ KDGDQHSLVRGHRIIHEULOHQHXWURSH QLDZLWK UHTXLULQJPDQDJHPHQWLQ,QWHQVLYH&DUH8QLW ,&8 )RFXVRILQIHFWLRQFRXOGEHLGHQWLᚏHGLQ RIWKHSDWLHQWVZLWK KDYLQJDSRVLWLYHFXOWXUH 7KHRYHUDOOLQFLGHQFHRILQGXFWLRQPRUWDOLW\ZDV Q 2IWKHGHDWKV Q ZHUHGXHWRLQIHFWLRXV FRPSOLFDWLRQV0HGLDQWLPHWRGHDWKIURPVWDUWRILQGXFWLRQZDV GD\V7KHLQFLGHQFHRIIXQJDOSQHXPRQLDVLJQLᚏ FDQWO\UHGXFHGVLQFHZKHQWKHDQWLIXQJDOSURSK\OD[LVZDVVZLWFKHGIURPᚐXFRQD]ROHWRYRULFRQD]ROH S 2YHUWKHODVW\HDUV WKHUHKDVEHHQDVLJQLᚏFDQWULVHLQWKHLQFLGHQFHRIPXOWLGUXJUHVLVWDQFHJUDP QHJDWLYH VHSWLFDHPLD DQG PRUWDOLW\ 0'5 FDUEDSHQHP UHVLVWDQW HQWHUREDFWHULDFHD VHQVLWLYH RQO\ WR FROLVWLQ DQG WLJHF\FOLQH 7KHSURSRUWLRQRIGHDWKVDWWULEXWDEOHWR0'5VHSVLVLV 7KHPHGLDQGXUDWLRQRIIROORZXSZDV PRQWKV7KHPHGLDQHYHQWIUHHVXUYLYDOZDV PRQWKV &, DQGWKHPHGLDQRYHUDOOVXUYLYDOZDV PRQWKV &, \HDURYHUDOOVXUYLYDOZDV ,PDJH
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47
'LVFXVVLRQ &RQFOXVLRQ 7KHLQGXFWLRQPRUWDOLW\UHPDLQVKLJKDWDQGLVLQFRQWUDVWWRWKHGHFOLQLQJLQGXF WLRQPRUWDOLW\LQZHVWHUQSRSXODWLRQ'HVSLWHLPSURYHPHQWVLQVXSSRUWLYHFDUHDQGHDUO\XVHRIEURDGVSHFWUXP DQWLPLFURELDODJHQWVLQIHFWLRQUHODWHGPRUELGLW\DQGPRUWDOLW\UHPDLQVDVXEVWDQWLDOFKDOOHQJHLQWUHDWLQJ$0/ Disclosure of Interest:1RQH'HFODUHG Keywords: $0/,QGXFWLRQ0RUWDOLW\0'5VHSVLV
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Stem Cell Transplant HAEMATOCON2018-382
NORMAL GROWTH AND DEVELOPMENT POST HAEMATOPOIETIC STEM CELL TRANSPLANTATION FOR THALASSEMIA MAJOR USING TREOSULFAN BASED CONDITIONING REGIMEN – SINGLE CENTRE LONG TERM STUDY .HVDYDQ05 6KLYDQL3DWHO0HHQD6LYDVDQNDUDQ9HQNDWHVZDUDQ961LNLOD55DP\D8SSXOXUL 5HYDWKL5DM
3DHGLDWULF+HPDWRRQFRORJ\$SROOR6SHFLDOLW\+RVSLWDO&KHQQDL,QGLD
Aims & Objectives: 7UHRVXOIDQEDVHGFRQGLWLRQLQJUHJLPHQKDVOLWWOHHᚎHFWRQORQJWHUPJURZWKLQ\RXQJFKLOGUHQ DQGKDVEHHQSUHGLFWHGWRSUHVHUYHIHUWLOLW\7KHDLPRIWKLVVWXG\LVWRGHWHUPLQHODWHHᚎHFWVRIWUHRVXOIDQEDVHG FRQGLWLRQLQJLQFKLOGUHQZLWKWKDODVVHPLDPDMRU Patients/Materials & Methods::HSHUIRUPHGDUHWURVSHFWLYHDQDO\VLVRIFKLOGUHQZKRXQGHUZHQW+6&7IRUWKDODV VHPLDPDMRUIURP WRLQDWHUWLDU\FHQWUH$OOFKLOGUHQUHFHLYHGDXQLIRUPSURWRFRORIWUHRVXOIDQJPP IRUGD\V LQIDQWVJPP ZLWKWKLRWHSDPJNJᚐXGDUDELQHPJPIRUGD\VZLWKDGGLWLRQDO$7*LQDIHZ FKLOGUHQ&KLOGUHQZHUHDQDO\VHGVXEVHTXHQWO\IRUWKHLUJURZWKSDUDPHWHUVDQGSXEHUWDOVWDWXVRQIROORZXS Results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iscussion & Conclusion 2XUVWXG\FOHDUO\GHPRQVWUDWHVWKHVXSHULRURXWFRPHRIFKLOGUHQWUHDWHGZLWKWUHRVXOIDQ EDVHG FRQGLWLRQLQJ UHJLPHQ IRUWKDODVVHPLD PDMRU ZLWK QRUPDO JURZWK SDWWHUQ DQG KDV KDG QR HᚎHFW RQ SXEHUWDO GHYHORSPHQW$OOJLUOVDWWDLQHGPHQDUFKHZLWKRXWWKHQHHGIRUDQ\VXSSOHPHQWDWLRQ,QYLHZRIWKHVHEHQHᚏWVZH UHFRPPHQGWKHXVHRIWUHRVXOIDQEDVHGFRQGLWLRQLQJIRUFKLOGUHQZLWKWKDODVVHPLDPDMRU Disclosure of Interest:1RQH'HFODUHG Keywords:JURZWKWKDODVVHPLDPDMRUWUHRVXOIDQ
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HAEMATOCON2018-342
CLINICAL PROFILE AND OUTCOMES POST ALLOGENIC HEMATOPOIETIC STEM CELL TRANSPLANTATION IN THALASSEMIA PATIENTS: A SINGLE CENTRE EXPERIENCE -\RWVQD.DSRRU 3UL\DQND6RQL1LKDULND%KDWLD1DUHQGUD$JUDZDO5D\D]$KPHG3DOODYL0HKWD 6KLQWR)UDQFLV7KHNNXGDQ$PEDU*DUJ'LQHVK%KXUDQL 'HSDUWPHQWRI+HPDWR2QFRORJ\DQG%RQH0DUURZ7UDQVSODQWDWLRQ8QLW5DMLY*DQGKL&DQFHU,QVWLWXWH$QG5H VHDUFK&HQWUH'HOKL,QGLD
Aims & Objectives: :HDLPWRUHSRUWRXUWKDODVVHPLDSDWLHQWVಬFOLQLFDOSURᚏOH RXWFRPHVSRVW$OOR6&7 3DWLHQWV0DWHULDOV 0HWKRGV 0HGLFDOUHFRUGVRIWKDODVVHPLDSDWLHQWVZKRUHFHLYHGDOOR6&7DWRXUFHQWUHEHWZHHQ VW-DQXDU\ VW0DUFKZHUHUHYLHZHG7KHIROORZXSZDVWDNHQWLOOWK$XJXVW Results: $ WRWDO RI WKDODVVHPLD SDWLHQWV PDOHV PHGLDQ DJHG \HDUV UHFHLYHG DOOR6&7 7KUHH SDWLHQWVKDG/XFDUHOOLFODVV,,,,,,UHVSHFWLYHO\ZLWK SDWLHQWVIDOOLQJLQFODVV ,,,$ ,,,%UHVSHFWLYHO\ 7KLUW\ᚏYH SDWLHQWVUHFHLYHGDOOR6&7XVLQJ06' 08'JUDIW*UDIWVRXUFHZDV%0 3%6&LQ SDWLHQWV UHVSHFWLYHO\ (QJUDIWPHQWZDVREVHUYHGLQSDWLHQWV DW GD\VZKLOHSDWLHQWVKDGHDUO\GHDWKV SDWLHQWVGHYHORSHGIHEULOHQHXWURSHQLDPXFRVLWLV 92'UHVSHFWLYHO\SRVWDOOR6&77UDQVLHQW &09YLUHPLDGHYHORSHGLQ SDWLHQWV$FXWH*9+'JUDGH,,,9 FKURQLF*9+'GHYHORSHGLQ SDWLHQWVUHVSHFWLYHO\$WGD\SDWLHQWV KDGIXOOGRQRUFKLPHULVP ุ GRQRUFKLPHULVP ZKLOHSDWLHQWVKDGPL[HGFKLPHULVP !GRQRUFKLPHULVP $OOSDWLHQWVZLWKPL[HGFKLPHULVPSUR JUHVVHGWRJUDIWUHMHFWLRQ 0DMRUHYHQWVZHUHJUDIWUHMHFWLRQ Q 150 Q $WPHGLDQIROORZXSRIPRQWKV\HDU26 ()6 LV s s )RXU\HDU 26 IRU SDWLHQWV ZLWK FODVV ,,,% RWKHU WKDQ ,,,% ZDV s sUHVSHFWLYHO\ 1RVLJQLᚏFDQWGLᚎHUHQFHLQWKH26 ()6ZDVIRXQGRQWKHEDVLVRIOXFDUHOOLFODVVW\SHRIGRQRU 06'YV08' JUDIWVRXUFH %0YV3%6& XVHG
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,PDJH
Discussion & Conclusion: )RXU\HDU26 ()6KDVEHHQ LQRXUGLYHUVHJURXSRIWKDODVVHPLD SDWLHQWV Disclosure of Interest: 1RQH'HFODUHG Keywords: $OORJHQHLFVWHPFHOOWUDQVSODQWDWLRQ7KDODVVHPLD
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51
HAEMATOCON2018-184
T315I MUTATION STATUS POST-HEMATOPOIETIC STEM CELL TRANSPLANTATION (HSCT) IN CHRONIC MYELOID LEUKEMIA(CML) AND PHILADELPHIA POSITIVE ACUTE LYMPHOBLASTIC LEUKEMIA (PH. ALL) (SERIES OF FIVE PATIENTS AND REVEIW OF ITS LITERATURE) 9DVX%*ROL *DQDSDWKL%KDW06DPLU6KDK$GYDQL6+5HHWX-DLQ 0HGLFDO2QFRORJ\DQG6WHP&HOO7UDQVSODQWDWLRQ+HPDWRORJLVWDQG6WHPFHOOWUDQVSODQWDWLRQ-DVORN+RVSLWDO DQG5HVHDUFK&HQWUH0XPEDL,QGLD
Aims & Objectives:7RDQDO\VHZKHWKHUSUHH[LVWLQJ7,PXWDWLRQSHUVLVWDIWHU$OORJHQLF+6&7LQSDWLHQWVRI &KURQLFP\HORLGOHXNDHPLDDQG3KLODGHOSKLDSRVLWLYH$FXWH/\PSKREODVWLFOHXNDHPLD Patients/Materials & Methods: $%/ .LQDVH PXWDWLRQ DQDO\VLV ZDV GRQH SURVSHFWLYHO\ XVLQJ 1HVWHG 3&5 DQG 6DQJHUVHTXHQFLQJ3UHDQG3RVW+6&7LQSDWLHQWVZKRKDYHGHWHFWDEOH%&5$%/WUDQVFULSWVLQ3K$//DQG&0/ SDWLHQWV Results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ᚐLFWLQJUHVXOWVRIUHWURVSHFWLYHDQDO\VHVUHVXOWHGLQ ODFNRIVWDQGDUGJXLGHOLQHVIRUXVHRISRVWWUDQVSODQWPDLQWHQDQFH7.,ಬV)XUWKHUVWXGLHVLQYROYLQJODUJHQXPEHURI SDWLHQWVDUHUHTXLUHGIRUXQGHUVWDQGLQJSRVWWUDQVSODQWF\WRJHQHWLFFORQDOHYROXWLRQDQGPXWDWLRQSDWWHUQVZKLFKZLOO KHOSLQVHOHFWLQJ3RVWWUDQVSODQW7.,3UHDQGSRVWWUDQVSODQWKLJKULVNIDFWRUVRUULVNVWUDWLᚏFDWLRQVFRUHVVKRXOGEH HYDOXDWHGIRULGHQWLI\LQJKLJKULVNSDWLHQWVZKREHQHᚏWIURPSRVWWUDQVSODQWPDLQWHQDQFH7.,ಬV Disclosure of Interest:1RQH'HFODUHG Keywords $OORJHQLFVWHPFHOOWUDQVSODQW7,0XWDWLRQ7\URVLQHNLQDVHLQKLELWRUV
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HAEMATOCON2018-245
TREOSULFAN BASED CONDITIONING REGIMEN – REDUCED TOXICITY WITH EXCELLENT OUTCOMES IN CHILDREN WITH PRIMARY IMMUNE DEFICIENCY 9HQNDWHVZDUDQ96 6KLYDQLSDWHO0HHQD6DQNDUDQ.HVDYDQ051LNLOD55DP\D85HYDWKL5
3HGLDWULF+HPDWRORJ\2QFRORJ\DQG%ORRGDQG0DUURZ7UDQVSODQWDWLRQ$SROOR&DQFHU,QVWLWXWHV&KHQQDL,QGLD
Aims & Objectives: 3ULPDU\ LPPXQH GHᚏFLHQF\ KDV YDULHG SUHVHQWDWLRQ DQG +6&7 ZLWK WDLORUHG FRQGLWLRQLQJ LV QRZWKHVWDQGDUGRIFDUHZKLFKPD\UHVXOWLQPL[HGFKLPHULVPDQGJUDIWUHMHFWLRQ:HSUHVHQWRXUGDWDRQWUHRVXOIDQ EDVHGFRQGLWLRQLQJUHJLPHQ Patients/Materials & Methods::HFRQGXFWHGDUHWURVSHFWLYHVWXG\LQRXU%ORRGDQG0DUURZ7UDQVSODQWDWLRQXQLW IURPWRDQGLQFOXGHGDOO3,'FKLOGUHQZKRUHFHLYHG7UHRVXOIDQDQGWKHLUGDWDZHUHDQDO\VHG Results: 2IWKH 3,'FKLOGUHQ 0 ) KDGUHFHLYHGWUHRVXOIDQLQFOXGLQJ+/+ 6&,' /$' &9,' :$6 +\SHU,J0 +\SHU,J( 060' ,/5DGHᚏFLHQF\ DQG&*' 7KHPH GLDQDJHDWSUHVHQWDWLRQZDVRQH\HDU$OORJHQHLFUHODWHG3%6&ZDVXVHGLQERQHPDUURZLQXQUHODWHGLQ FRUGEORRGLQDQGKDSORLGHQWLFDOERQHPDUURZLQ5HJLPHQUHODWHGWR[LFLW\ZHUHUDVK FRQMXQFWL YLWLV PLOGPXFRVLWLV JUDGHPXFRVLWLV 2YHU RIWKHFKLOGUHQKDGPL[HGFKLPHULVPDIWHUGD\V PDQDJHGZLWKHDUO\ZLWKGUDZDORILPPXQRVXSUHVVLRQ:HQRWLFHGDFXWH*Y+'FKURQLF*Y+'LQDQGJUDIW UHMHFWLRQLQ7KHPRUWDOLW\ZDVWKHFDXVHEHLQJVHSVLVLQ$5'6LQGLVVHPLQDWHG&09DQG SURJUHVVLYH+/+LQHDFK Discussion & Conclusion: 7UHRVXOIDQEDVHGUHJLPHQLVZHOOVXLWHGIRU3,'FKLOGUHQ7KHFKLPHULVPQHHGVWREH IROORZHGXSDQGLPPXQRVXSUHVVLRQZLWKGUDZQDVLWGURSVOHVVWKDQ 7KLVLVSDUWLFXODUO\UHOHYDQWLQ,QGLDZKHUH EXVXOIDQSKDUPDFRNLQHWLFVLVQRWDYDLODEOHHYHU\ZKHUHDQGLQGLYLGXDOLVHGWKHUDS\LVWKHNH\IRUVXFFHVVIXORXWFRPH Disclosure of Interest:1RQH'HFODUHG Keywords:WUHRVXOIDQUHJLPHQUHODWHGWR[LFLW\PL[HGFKLPHULVP
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HAEMATOCON2018-480
OUTCOMES OF ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION FOR LYMPHOMAS: A SINGLE-CENTRE EXPERIENCE 6XVKLO6HOYDUDMDQ $QX.RUXOD)RX]LD1$$E\$EUDKDP$ORN6ULYDVWDYD9LNUDP0DWKHZV%LMX *HRUJH
'HSDUWPHQWRI&OLQLFDO+HPDWRORJ\&KULVWLDQ0HGLFDO&ROOHJH9HOORUH,QGLD
Aims & Objectives: 0XOWLSO\ UHODSVHGUHIUDFWRU\ O\PSKRPDV UHSUHVHQW D JURXS RI KHPDWRO\PSKRLG QHRSODVPV ZKLFKKDYHUHPDLQHGDFKDOOHQJHWRWUHDWGHVSLWHWKHDGYHQWRIQHZHUVDOYDJHFRPELQDWLRQFKHPRWKHUDSLHVPR QRFORQDODQWLERGLHV FHOOEDVHGWKHUDSLHV(ᚎHFWLYHQHVVRIDOORJHQHLF6WHP&HOO7UDQVSODQWDWLRQLQWKLVSRSXODWLRQ RISDWLHQWVKDVEHHQDWWULEXWHGWRJUDIWYHUVXVOHXNHPLD *9/ HᚎHFWEHFDXVHRIWKHHOLPLQDWLRQRIWXPRUFHOOVE\ DOORLPPXQHHᚎHFWRU7O\PSKRF\WHV7KLVVWXG\UHSRUWVWKHH[SHULHQFHRIRXUFHQWHURQDOORJHQHLFWUDQVSODQWIRUKLJK ULVN UHODSVHGUHIUDFWRU\O\PSKRPDV Patients/Materials & Methods: $OOSDWLHQWVZLWKKLVWRORJLFDOO\FRQᚏUPHGGLDJQRVLVRI+RGJNLQRUQRQ+RGJNLQO\P SKRPDZKRXQGHUZHQWDOORJHQHLF+6&7IURPWRZHUHUHWURVSHFWLYHO\VWXGLHG'DWDZDVFROOHFWHGIURP VWDQGDUGL]HGLQVWLWXWLRQDOLQGLYLGXDOPHGLFDOUHFRUGVWDEXODWHGDQGVXEVHTXHQWO\DQDO\VHGZLWKWKH6366VRIWZDUH YHUVLRQ Results: 7KLUW\RQHSDWLHQWVXQGHUZHQWWUDQVSODQW KDG+RGJNLQO\PSKRPDDQGRIWKHUHPDLQLQJSDWLHQWV ZHUH%&HOODQGZHUH7&HOOO\PSKRSUROLIHUDWLYHGLVRUGHUV7KHPHGLDQDJHZDV\UV 5DQJH \UV \HDUV DQG ZHUHPDOH7KHPDMRULW\RISDWLHQWV KDGUHFHLYHGRUPRUHOLQHVRIFKHPRWKHUDS\$WWKH WLPHRIDOORJHQHLFWUDQVSODQWDWLRQ SDWLHQWVZHUHLQFRPSOHWHUHPLVVLRQದ LQ&5DQG LQ ! &52IWKHUHPDLQLQJ ZHUHLQSDUWLDOUHPLVVLRQDQG KDGUHIUDFWRU\GLVHDVHDWSUHWUDQVSODQW DVVHVVPHQW SDWLHQWVUHFHLYHGQRQP\HORDEODWLYHFRQGLWLRQLQJDQGWKHUHPDLQLQJUHFHLYHGP\HORDEODWLYH UHJLPHQV7KLVZDVIROORZHGE\VWHPFHOOWUDQVSODQWDWLRQRIZKLFK UHFHLYHGPDWFKHGUHODWHGGRQRUJUDIWV DQG UHFHLYHGKDSORLGHQWLFDOGRQRUJUDIWV7KHGD\WUHDWPHQWUHODWHGPRUWDOLW\UDWHZDV7KH \UHYHQWIUHHDQGRYHUDOOVXUYLYDOZDVs DQGs UHVSHFWLYHO\ 0HGLDQIROORZXSEHLQJPRQWKV 2Q XQLYDULDWH DQDO\VLV SUHWUDQVSODQW UHPLVVLRQ VWDWXV DQG SUHVHQFH RI FKURQLF *UDIW 9V +RVW 'LVHDVH F*Y+' ZHUHERWKIRXQGWRKDYHVWDWLVWLFDOO\VLJQLᚏFDQWLPSDFWRQRXWFRPHV,QWKHJURXSVRISDWLHQWVLQ!&53535 DQGWKRVHZLWKUHIUDFWRU\GLVHDVHSUHWUDQVSODQWWKH()6DW\HDUVZDV ssDQGs UHVSHFWLYHO\ S 3DWLHQWVZKRGHYHORSHGF*Y+'SRVWWUDQVSODQWDOVRKDGVLJQLᚏFDQWO\EHWWHUVXUYLYDO FKDUDFWHULVWLFV ()6DW\UV s9Vs S 2XWFRPHGLᚎHUHQFHVDPRQJWKHSDWLHQW JURXSVZLWKYDULRXVGLVHDVHVXEW\SHV +RGJNLQYV1RQ+RGJNLQ/\PSKRPDV DQGWKRVHUHFHLYLQJP\HORDEODWLYH9V QRQP\HORDEODWLYHFRQGLWLRQLQJZHUHQRWVWDWLVWLFDOO\VLJQLᚏFDQW Discussion & Conclusion: $OORJHQHLFWUDQVSODQWVDUHDVVRFLDWHGZLWKUHDVRQDEOHGLVHDVHFRQWUROLQSDWLHQWVZLWK UHODSVHGUHIUDFWRU\O\PSKRPD+DSORLGHQWLFDOJUDIWVUHPDLQDQRSWLRQIRUSDWLHQWVLQWKLVJURXS)DFWRUVWKDWKDGD IDYRUDEOHLPSDFWRQRXWFRPHVZHUHWKHSUHWUDQVSODQWUHPLVVLRQVWDWXVDQGSUHVHQFHRIFKURQLF*Y+' Disclosure of Interest: 1RQH'HFODUHG Keywords:$OORJHQHLFVWHPFHOOWUDQVSODQWDWLRQO\PSKRSUROLIHUDWLYHGLVRUGHUV5HIUDFWRU\/\PSKRPD
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HAEMATOCON2018-451
A PROSPECTIVE OBSERVATIONAL STUDY OF INCIDENCE OF EARLY CYTOMEGALOVIRUS REACTIVATION AND FACTORS AFFECTING IT FOLLOWING ALLOGENEIC STEM CELL TRANSPLANTATION %KDUDWK5DP6 6XQLO%KDW1DWDUDM.66KREKD%DGLJHU9DVXQGKDUD3RVDYDQLNH.DLODVQDWK 3RRMD0DOO\D0XNHVK&KDZOD$QQDSDQGLDQ906KDUDW'DPRGDU
'HSDUWPHQWRI+HPDWRRQFRORJ\$FDGHPLFGHSDUWPHQW1DUD\DQD+HDOWK&LW\%DQJDORUH,QGLD
Aims & Objectives:&\WRPHJDORYLUXV &09 UHPDLQVRQHRIWKHPRVWLPSRUWDQWFRPSOLFDWLRQVDIWHUDOORJHQHLFKH PDWRSRLHWLFVWHPFHOOWUDQVSODQWDWLRQ +6&7 DVVRFLDWHGZLWKKLJKPRUELGLW\DQGPRUWDOLW\:HDLPHGWRHYDOXDWHWKH LQFLGHQFHRIHDUO\&09 ืGD\V UHDFWLYDWLRQIROORZLQJDOORJHQHLFKHPDWRSRLHWLFVWHPFHOOWUDQVSODQWDWLRQDQG VWXG\WKHIDFWRUVDVVRFLDWHGZLWKUHDFWLYDWLRQDQGWLPHWRUHDFWLYDWLRQ Patients/Materials & Methods: 1LQHW\VHYHQ FRQVHFXWLYH SDWLHQWV XQGHUJRLQJ DOORJHQHLF +6&7 ZHUH DQDO\]HG SURVSHFWLYHO\IRUF\WRPHJDORYLUXVUHDFWLYDWLRQWLOOGD\SRVWWUDQVSODQWIURP0DUFKWR$SULODW0D ]XPGDU6KDZ0HGLFDO&HQWHU1DUD\DQD+HDOWK&LW\%DQJDORUH4XDOLWDWLYH&09SRO\PHUDVHFKDLQUHDFWLRQ &09 3&5 SRVLWLYLW\RUTXDQWLWDWLYH&093&5!FRSLHVZHUHFRQVLGHUHGDVDFULWHULRQIRU&09UHDFWLYDWLRQ3UHHPS WLYH WKHUDS\ ZDV DGPLQLVWHUHG LQ SDWLHQWV ZLWK TXDQWLWDWLYH &09 3&5 ุ FRSLHV RU ุ FRSLHV LQ KLJKULVN WUDQVSODQWV Results: )LIW\WKUHH SDWLHQWV GHYHORSHG &09 UHDFWLYDWLRQ DQG SDWLHQWV UHTXLUHG SUHHPSWLYH WKHUDS\2QHSDWLHQW GHYHORSHGJDVWURLQWHVWLQDO&09GLVHDVH0HGLDQGD\RIUHDFWLYDWLRQRIF\WRPHJDORYLUXV LQWKLVVHULHVZDV GD\V 5DQJH GD\V 0XOWLYDULDWHDQDO\VLVRIIDFWRUVDᚎHFWLQJ&09UHDFWLYDWLRQ SUHHPSWLYH WKHUDS\JURXS UHYHDOHG&09LQIHFWLRQZDVVLJQLᚏFDQWO\LQFUHDVHGLQSDWLHQWVZKRZHUHUHFHLYLQJVWHURLGVุPJ SUHGQLVRQH RU HTXLYDOHQW 3 :KLOH RWKHU IDFWRUV VXFK DV P\FRSKHQRODWH 25 &, 3 DQGJUDGHDFXWHJUDIWYHUVXVKRVWGLVHDVH D*9+' 25 &,WR 3 ZHUH DVVRFLDWHGZLWKLQFUHDVHGRGGVWRUHDFWLYDWLRQEXWZHUHQRWVLJQLᚏFDQWVWDWLVWLFDOO\0HGLDQWLPHWRUHDFWLYDWLRQZDV VLJQLᚏFDQWO\ HDUOLHU LQ DQWLWK\PRF\WH JOREXOLQ $7* DUP GD\V ,45 3 FRPSDUHG WR QRQ $7*DUP GD\V,45GD\V $PRQJRWKHUIDFWRUVRQO\PDWFKHGXQUHODWHGGRQRUWUDQVSODQWDWLRQJURXS VKRZHGHDUOLHUUHDFWLYDWLRQV GD\V,45GD\V FRPSDUHGWRPDWFKHGVLEOLQJWUDQVSODQWDWLRQJURXS GD\V,45 GD\V EXWZDVQRWVWDWLVWLFDOO\VLJQLᚏFDQW 3 ,PDJH
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'LVFXVVLRQ &RQFOXVLRQ 7KLV VWXG\ VKRZV WKDW WKH LQFLGHQFH RI &09 UHDFWLYDWLRQ EXUGHQ LV VLJQLᚏFDQW LQ WKH SRVWWUDQVSODQWDWLRQSHULRG6WHURLGVZHUHDVVRFLDWHGZLWKDVLJQLᚏFDQWO\KLJKHULQFLGHQFHRIUHDFWLYDWLRQDQG$7* ZLWKHDUOLHUUHDFWLYDWLRQV7KLVLQIRUPDWLRQLVLPSRUWDQWIRUWUDQVSODQWFHQWHUVLQGHYHORSLQJFRXQWULHVDVWKLVDGGVWR WKHHFRQRPLFEXUGHQRIVWHPFHOOWUDQVSODQW Disclosure of Interest: 1RQH'HFODUHG Keywords: $OORJHQHLFVWHPFHOOWUDQVSODQWDWLRQ&\WRPHJDORYLUXV5HDFWLYDWLRQ
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Lymphoma and Myeloma HAEMATOCON2018-198
IS PET/CT SCAN SUFFICIENT IN DETECTING BONE MARROW INFILTRATION IN LYMPHOMA? $QNLW.-LWDQL 6K\DPDOL'XWWD5DMLE'H3UDNDV.XPDU0DQGDO6KXYUD1HHO%DXO7XSKDQ.DQWL 'RODL7XVWL*DQJXO\3UDQWDU&KDNUDEDUWL
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HAEMATOCON2018-426
IMPACT OF IMAGING MODALITY ON CLINICAL OUTCOME IN HODGKIN LYMPHOMA IN A RESOURCE CONSTRAINED SETTING $QX.RUXOD )RX]LD1$$QXS'HYDVLD8GD\.XONDUQL$E\$EUDKDP$ORN6ULYDVWDYD%LMX *HRUJH9LNUDP0DWKHZV
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HAEMATOCON2018-396
RENAL SALVAGE WITH BORTEZOMIB / CYCLOPHOSPHAMIDE / DEXAMETHASONE THERAPY IN NEWLY DIAGNOSED MULTIPLE MYELOMA PATIENTS WITH RENAL INSUFFICIENCY: A SINGLE-CENTER STUDY 8WWDP.1DWK 5LWXSDUQD&KHWLD
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HAEMATOCON2018-364
PREVALENCE OF ALPHA TRIPLICATION AMONG BETA THALASSAEMIA PATIENTS: STUDY IN A TERTIARY CENTER, WEST BENGAL $QNLWD%LVZDV 5XGUD5D\6XQLVWKD%KDWWDFKDUMHH0DLWUH\HH%KDWWDFKDU\\D
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HAEMATOCON2018-368
COMPARATIVE EVALUATION OF VARIOUS RED CELL INDICES FOR SCREENING OF BETA THALSSEMIA TRAIT 6DPDQ\R\D*RFKKDLW $GLWL.XQGRR*DXUDY&KKDEUD6XVDPD3DWUD
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HAEMATOCON2018-208
COMBINED FACTOR V AND VIII DEFICIENCY: CASE REPORT OF AN UNIQUE ENTITY AMONG HEMOSTATIC DISORDERS .DUWKLN5DPDNULVKQDQ 6KDQWKD.-DYHG$KDPPDG$QQDPPD.XULHQ 'HSDUWPHQWRI3DWKRORJ\.DVWXUED0HGLFDO&ROOHJH0DQLSDO'HSDUWPHQWRI3DWKRORJ\0HODND0DQLSDO0HGLFDO &ROOHJH0DQLSDO8GXSL,QGLD
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HAEMATOCON2018-547
DIAGNOSTIC UTILITY OF NEUTROPHIL-CD64, MONOCYTE HLA-DR AND CD16 IN NEONATAL SEPSIS 6QHKD*RVZDPL 5LFKD*XSWD6LGGKDUWK5DPML 'HSDUWPHQWRI3DWKRORJ\8QLYHUVLW\&ROOHJHRI0HGLFDO6FLHQFHV'HSDUWPHQWRI1HRQDWRORJ\0DXODQD$]DG 0HGLFDO&ROOHJH1HZ'HOKL,QGLD
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TO FORMULATE A BASELINE THRESHOLD OF HEMOGLOBIN HEMATOCRIT IN A POPULATION FOR THE INITIATION OF PROPHYLACTIC OR A THERAPEUTIC INTERVENTION IN THE FORM OF RBC BLOOD TRANSFUSION. 6DQNDOS6KDUPD 0XUOLGKDU9RUD3UDVKHHN&KDZKDQ6DXUDEK/HKUH
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HAEMATOCON2018-191
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HAEMATOCON2018-400
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HAEMATOCON2018-410
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HAEMATOCON2018-506
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HAEMATOCON2018-507
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HAEMATOCON2018-550
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A CASE OF MULTIPLE MYELOMA WITH PLASMABLASTIC MORPHOLOGY- A RARE VARIANT 60RQLFD (QDP0XUVKHG.KDQ$WRVKL%DVX
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HAEMATOCON2018-321
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HAEMATOCON2018-331
CASE STUDY OF MULTIPLE MYELOMA IN HIV +VE PATIENT 0DGKX6LQJK 'HSDUWPHQWRI3DWKRORJ\173&/LPLWHG
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