Apr 28, 2016 - Please cite this article as: Arnold Piek, Wouter C. Meijers, Nicolas F. .... creatinine and hsTnT were measured using the Roche Modular system ...
Journal of Cardiac Failure Vol. 23 No. 1 2017
Clinical Investigation
HE4 Serum Levels Are Associated with Heart Failure Severity in Patients With Chronic Heart Failure ARNOLD PIEK, BSc,1 WOUTER C. MEIJERS, MD,1 NICOLAS F. SCHROTEN, MD, PhD,1,3 RON T. GANSEVOORT, MD, PhD,2 RUDOLF A. DE BOER, MD, PhD,1 AND HERMAN H.W. SILLJÉ, PhD1 Groningen and Amsterdam, The Netherlands
ABSTRACT Background: The novel biomarker human epididymis protein 4 (HE4) shows prognostic value in acute heart failure (HF) patients. We measured HE4 levels in patients with chronic heart failure (CHF) and correlated them to HF severity, kidney function, and HF biomarkers, and determined its predictive value. Methods: Serum HE4 levels in patients (n = 101) with stable CHF with reduced left ventricular ejection fraction (LVEF
