Helicobacter pylori - Hindawi

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RECENT A DVANCES IN ACID PEPTlC DISEASE

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Hp and pH: IInplications for the eradication of Helicobacter pylori RI\ ·11 \Ill)

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RH HUNT. Hp and pH: Implications for the eradication of Helicobucter pylori. Can J Gastroenterol 1993;7(5):406-410. Helico/Jacccr /)y/ori infecti(,n c.1u,cs inf1am1rn1rinn of the gn,rric and duodenal mucosae, which re~ulrs in ,1 disturban ce uf the rc.l!ulatPry mechanisms ft11· gasrri n . g,,stric acid and pepsin ~ecreti,m. Acid sec ret ion may be decreased, normal (1r increased, depend ing on the ,rage nf infec ti,m, ,ilthough the meal-stimulated gn~trin n:srome is invnriuhly elevated. The ex,1ct mcchani\ms invnlvt·d arc n,1t known hut may l~e due tn rhL· rdc,1~L' ol cytokmes in rt•spome LO bactcriDl toxim. 1I J,ylori colonb1ti un is l'L'ducl'd hy o.:ffocriw ,Kid surrrcs~inn with protlln pump inhibitor,. although it b not crndi catL'LI. In combi nation with .imoxycillin, om.:prn::olc, up to 40 mg t wice dail y, .:radicatcd rhe organism in ur w 82% of case:,.. This synergbtic. effect may he due t,1 a direct effect of nmcpram lc on the organbm, the pr(>tccLion of amoxycillin from acid degrndat i\111, or enhance men t of host defe nce mechanisms accomp;111) ing ,icid suppressiun.

Key Wl)rds: A111oxycillin, Duodenal ulcer, Eradication, Gastric acid. I lcl trnbactcr pylori , Ome{>razole, j)[ 1

«Hp» ct pH: implications pour !'eradication de Helicobacter pylori RESUME: L'infection n Helicohactt?'I·

/)yUni provuque une inflamm.11 inn des muqueLbe~ga~criques ct duodenales, qui resulre en unc alteration des mecant~mc~

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