Mar 7, 2014 - tonin against necrosis-inducing DNA damage in hepa- tocytes of streptozotocin (STZ)-induced diabetic rats. Daily administration of melatonin ...
J Physiol Biochem (2014) 70:441–450 DOI 10.1007/s13105-014-0322-7
Received: 8 November 2013 / Accepted: 4 February 2014 / Published online: 7 March 2014 # University of Navarra 2014
Abstract Oxidative stress-mediated damage to liver tissue underlies the pathological alterations in liver morphology and function that are observed in diabetes. We examined the effects of the antioxidant action of melatonin against necrosis-inducing DNA damage in hepatocytes of streptozotocin (STZ)-induced diabetic rats. Daily administration of melatonin (0.2 mg/kg) was initiated 3 days before diabetes induction and maintained for 4 weeks. Melatonin-treated diabetic rats exhibited improved markers of liver injury (P
