Hippocampal CA4 Reelin-positive neurons - Nature

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Page 1 ... Hippocampal CA4 Reelin-positive neurons. SH Fatemi, JA Earle and T McMenomy. University of Minnesota Medical School, Department of Psychiatry, ...
Molecular Psychiatry (2000) 5, 571  2000 Stockton Press All rights reserved 1359–4184/00 $15.00 www.nature.com/mp

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Hippocampal CA4 Reelin-positive neurons SH Fatemi, JA Earle and T McMenomy University of Minnesota Medical School, Department of Psychiatry, Division of Neuroscience Research, Minneapolis, MN 55455, USA

Several Reelin-positive cells are localized to the hilus (CA4) of hippocampal complex. M = dentate inner molecular layer, GC = granular cell layer, ×40 magnification. The role of reelin, a secretory glycoprotein involved in normal lamination of the brain, in depression and schizophrenia is presented in the article by Fatemi et al in this issue (pages 654–663). Those results suggest that abnormalities in reelin are not restricted to schizophrenia and highlight the need for psychiatric control groups in molecular psychiatry studies.