RESEARCH ARTICLE
Hyperopic refractive correction by LASIK, SMILE or lenticule reimplantation in a nonhuman primate model Geraint P. Williams1,2☯, Benjamin Wu3☯, Yu Chi Liu1, Ericia Teo1, Chan L. Nyein1, Gary Peh1, Donald T. Tan1,2,3,4, Jodhbir S. Mehta1,2,3,5*
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1 Tissue Engineering and Stem Cell Group, Singapore Eye Research Institute, Singapore, 2 Singapore National Eye Centre, Singapore, 3 Ophthalmology Academic Clinical Program, Duke-NUS Graduate Medical School, Singapore, 4 Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 5 Department of Clinical Sciences, Duke-NUS Graduate Medical School, Singapore ☯ These authors contributed equally to this work. *
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Abstract OPEN ACCESS Citation: Williams GP, Wu B, Liu YC, Teo E, Nyein CL, Peh G, et al. (2018) Hyperopic refractive correction by LASIK, SMILE or lenticule reimplantation in a non-human primate model. PLoS ONE 13(3): e0194209. https://doi.org/ 10.1371/journal.pone.0194209 Editor: Dimitrios Karamichos, Oklahoma State University Center for Health Sciences, UNITED STATES Received: September 18, 2017 Accepted: February 27, 2018 Published: March 28, 2018 Copyright: © 2018 Williams et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Hyperopia is a common refractive error, apparent in 25% of Europeans. Treatments include spectacles, contact lenses, laser interventions and surgery including implantable contact lenses and lens extraction. Laser treatment offers an expedient and reliable means of correcting ametropia. LASIK is well-established however SMILE (small-incision lenticule extraction) or lenticule implantation (derived from myopic laser-correction) are newer options. In this study we compared the outcomes of hyperopic LASIK, SMILE and lenticule re-implantation in a primate model at +2D/+4D treatment. While re-implantation showed the greatest regression, broadly comparable refractive results were seen at 3-months with SMILE and LASIK (
