Oct 20, 2014 - bIVIOMICS, Paterna, Valencia, Spain; cIllumina, Fulbourn, Cambridge, United. Kingdom; dFundación Instituto Valenciano de Infertilidad, Incliva ...
OHSS IVF and SC children. Intima-media thickness and arterial stiffness indices were similar in three groups. In proteomics study, 1640 proteins were identified from OHSS and SC umbilical arteries, and, 39 differentially expressed proteins were selected for further analysis. Estradiol was identified as activated upstream regulators. CONCLUSION: Children born to women with OHSS displayed cardiovascular dysfunctions. The underlying mechanisms may involve the effect of supraphysiological estradiol levels. Supported by: This work was Supported by the National Basic Research Program of China (2012CB944900, No.2013CB967404), the National Natural Science Foundation of China (31171444, 81170310, 81200485). Talent Project of Zhejiang Province (2011RCA028), Public Welfare Technology Project of Zhejiang Province (2010C33167). O-68 Monday, October 20, 2014 05:45 PM COMPARATIVE ANALYSIS OF THE CLINICAL RESULTS OF MILD STIMULATION CYCLES AND CONTROLLED STIMULATION CYCLES FOR ART PATIENTS LESS THAN 40 YEARS OLD. A. Tanaka. Saint Mother Hospital, Kitakyushu, Fukuoka, Japan. OBJECTIVE: The aim of this study is to compare the conventional controlled ovarian hyper stimulation method with the mild stimulation method, from a Japanese perspective. In 2011, Japan reported the largest number of ART cycles performed (161,980) and the largest number of ART institutions (650) in the world. Consequently, the present article has significant global relevance. DESIGN: Randomized prospective study to compare the clinical results of MS (Mild stimulation) and CS (Controlled stimulation) in Japan. MATERIALS AND METHODS: At 18 Institutional members of JISART (Japanese Institution for Standardizing Assisted Reproductive Technology) conducted a randomized prospective study to compare the clinical results of MS and CS in Japan. Patients were divided by age into two groups, younger than 35 years old (referred to as the ‘Younger Group’) and between 35 and 39 years old (referred to as the ‘Older Group’). We analyzed clinical outcomes of MS and CS methods from two points of view, as detailed below: 1. A comparison of results between the two groups according to fresh embryo transfer or frozen-thawed embryo transfer. 2. A comparison of clinical results in the mild stimulation group according to the volume of hMG used (two or less 150 IU ampoules versus 3 or more 150 IU ampoules). RESULTS: 1. Results are summarized in table. Clinical results in MS or CS Fresh embryo transfer MS %34
Pregnancy rates (per cycle) %34 Miscarriage rates R35%39 Pregnancy rates (per cycle) R35%39 Miscarriage rates
CS
Frozen-thawed embryo transfer MS
CS
22.7% 34.9% 55.8% (24/43) 53.2% (17/75) (37/106) (50/94) 23.5% 24.3% 25.0% (6/24) 14.3% (4/17) (9/37) (7/49) 10.3% A 34.2% a 20.4% B 42.7% b (10/97) (52/152) (11/54) (35/82) 10.0% 28.8% 27.3% (3/11) 22.9% (1/10) (15/52) (8/35)
2. Statistically significant differences were found between CS and MS in older group when three Ampoles or more of hMG (3A hMG) were used after frozen-thawed embryo transfer.
O-69 Monday, October 20, 2014 06:00 PM GONADOTROPIN DOSE IS INVERSELY CORRELATED WTH LIVE BIRTH RATE: AN ANALYSIS OF 541,967 ART CYCLES. V. L. Baker,a M. B. Brown,b B. Luke,c G. W. Smith,d J. J. Ireland.e aObstetrics and Gynecology, Stanford University, Palo Alto, CA; bBiostatistics, School of Public Health, University of Michigan, Ann Arbor, MI; cObstetrics, Gynecology, and Reproductive Biology, Michigan State University, East Lansing, MI; dAnimal Science, Michigan State University, East Lansing, MI; eAnimal Science, Michigan State University, East Lansing, MI. OBJECTIVE: To examine the correlation between total gonadotropin dosage and live birth rate. DESIGN: Retrospective analysis of fresh autologous cycles reported to the Society for Assisted Reproductive Technology from 2004 to 2011. MATERIALS AND METHODS: Logistic regression models were created using categorical values for total gonadotropin dose as the primary predictor variable and live birth rate as the primary outcome variable. Differences were evaluated based on number of oocytes retrieved. RESULTS: Live birth rate decreased with increasing gonadotropin dose, regardless of the number of oocytes retrieved (see Table, p30, except for cycles for women >40 years of age with 1-5 oocytes retrieved.
Effect of gonadotropin dose on live birth rate
Live birth rate (%) Number of oocytes retrieved
All
1-5 6-10 11-15 16-20 21-25 >25
Gonadotropin dose (IU)
