Increased serum adiponectin levels in type 1 diabetic ... - Springer Link

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Aug 3, 2005 - (n=106) or proliferative retinopathy (n=19), and nephrop- athy with simplex (n=62) or proliferative retinopathy. (n=137). Healthy control subjects ...
Diabetologia (2005) 48: 1911–1918 DOI 10.1007/s00125-005-1850-z

ARTICLE

J. Frystyk . L. Tarnow . T. Krarup Hansen . H.-H. Parving . A. Flyvbjerg

Increased serum adiponectin levels in type 1 diabetic patients with microvascular complications Received: 21 December 2004 / Accepted: 18 April 2005 / Published online: 3 August 2005 # Springer-Verlag 2005

Abstract Aims/hypothesis: Low serum adiponectin (ADPN) has been associated with increased risk of cardiovascular disease (CVD) and retinopathy in patients with type 2 diabetes mellitus. In type 1 diabetic patients, the relationship between ADPN and the presence of vascular complications is largely unknown. Methods: We investigated the relationship between serum ADPN and the presence of retinopathy, nephropathy and CVD in patients with type 1 diabetes, divided into matched groups with normoalbuminuria and no retinopathy (n=67), simplex retinopathy (n=106) or proliferative retinopathy (n=19), and nephropathy with simplex (n=62) or proliferative retinopathy (n=137). Healthy control subjects (n=25) were included. Results: Serum ADPN was increased in subjects with type 1 diabetes compared with control subjects (p