Original Article
http://dx.doi.org/10.3349/ymj.2014.55.4.912 pISSN: 0513-5796, eISSN: 1976-2437
Yonsei Med J 55(4):912-919, 2014
Increased Serum Cathepsin K in Patients with Coronary Artery Disease Xiang Li,1 Yuzi Li,1 Jiyong Jin,1 Dehao Jin,2 Lan Cui,1 Xiangshan Li,3 Yanna Rei,1,4 Haiying Jiang,5 Guangxian Zhao,1 Guang Yang,1 Enbo Zhu,1 Yongshan Nan,4 and Xianwu Cheng1,6,7 Department of Cardiology, 2Intervention Laboratory, 3Central Laboratory, and 4Anesthesiology, Yanbian University Hospital, Yanji, Jilin P.R., China; 5 Department of Physiology and Pathophysiology, Yanbian University Medical College, Yanji, Jilin P.R., China; 6 Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan; 7 Department of Internal Medicine, Kyung Hee University Hospital, Seoul, Korea.
1
Received: September 13, 2013 Revised: October 5, 2013 Accepted: October 11, 2013 Co-corresponding authors: Dr. Lan Cui, Department of Cardiology, Yanbian University Hospital, Yanjishi 133000, Jilin Province, China. Tel: 86-433-2660063, Fax: 86-433-2513510 E-mail:
[email protected] and Dr. Xianwu Cheng, Department of Cardiology, Nagoya University Graduate School of Medicine, 65 Tsuruma-cho, Showa-ku, Nagoya 466-8550, Japan. Tel: 81-52-744-2364, Fax: 81-52-744-2371 E-mail:
[email protected] ∙ The authors have no financial conflicts of interest.
Purpose: Cathepsin K is a potent collagenase implicated in human and animal atherosclerosis-based vascular remodeling. This study examined the hypothesis that serum CatK is associated with the prevalence of coronary artery disease (CAD). Materials and Methods: Between January 2011 and December 2012, 256 consecutive subjects were enrolled from among patients who underwent coronary angiography and percutaneous coronary intervention treatment. A total of 129 agematched subjects served as controls. Results: The subjects’ serum cathepsin K and high sensitive C-reactive protein (hs-CRP) and high-density lipoprotein cholesterol were measured. The patients with CAD had significantly higher serum cathepsin K levels compared to the controls (130.8±25.5 ng/mL vs. 86.9±25.5 ng/mL, p
