3000. 4000. 5000. 6000. 7000. 8000. 9000. 10000. **. **. **. **. 0. 0.2. 0.4. 0.6. 0.8. 1. 1.2. 1.4. 1.6. 1.8. Fold of le ptin Inc re a s ing. IL-6. C o n c e n tra tio n. (p g.
Azizah Al-Anazi Department Of Cell Biology, King Faisal Specialist Hospital and Research Centre Riyadh, Saudi Arabia.
FACTS: • Globally, there are more than 1.4 billion adults, 20 and older, were overweight, at least 300 million of them obese.
• More than 40 million children under the age of five were overweight in 2011. • The key causes are increased consumption of energydense foods high in saturated fats and sugars, and reduced physical activity.
Medical Complications of Obesity • • • •
Types 2 diabetes Cardiovascular Diseases Hypertension Cancer
Obesity in KSA
Adipose Tissue
British Journal of Nutrition
Endocrine function of the adipocyte
Journal of Clinical Endocrinology & Metabolism 2004
Adipocytes alone may constitute the major source of inflammatory adipokines and cytokines.
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Hypoxia may be a sufficient stimulus for adiopocyte dependent inflammatory mediators release.
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Our result with YC-1 suggest HIF-1α - dependent and independent interplay in the production of these inflammatory cytokines.
Department of Cell Biology, KFSH&RC Dr. Futwan Al-Mohanna, Director Dr. Kate Collison Dr. Ranjit Parhar Reem Al-Hijailan Soad Saleh Angela Inglis Dr. Walter Conca, Department of Medicine. Dr. Mansour Al-Jufan, Department of Surgery.
Collaboration with KSU Dr. Mohammed D. Bazzi, Department of Biochemistry.
