UOC di Diabetologia Universitaria, Ospedale Santa Maria. Goretti, Latina, Italy. 6. Division of Endocrinology and Metabolism, University of Foggia, Foggia, Italy.
Eur J Nutr DOI 10.1007/s00394-015-0983-1
ORIGINAL CONTRIBUTION
Influence of dietary fat and carbohydrates proportions on plasma lipids, glucose control and low‑grade inflammation in patients with type 2 diabetes—The TOSCA.IT Study M. Vitale1 · M. Masulli1 · A. A. Rivellese1 · A. C. Babini2 · M. Boemi3 · E. Bonora4 · R. Buzzetti5 · O. Ciano1 · M. Cignarelli6 · M. Cigolini4 · G. Clemente1 · G. Citro7 · L. Corsi8 · E. Dall’Aglio9 · S. Del Prato10 · G. Di Cianni11 · M. A. Dolci12 · C. Giordano13 · R. Iannarelli14 · C. Iovine1 · A. Lapolla15 · D. Lauro16 · S. Leotta17 · C. Mazzucchelli18 · V. Montani19 · G. Perriello20 · G. Romano1 · F. Romeo21 · L. Santarelli22 · R. Schiano di Cola1 · S. Squatrito23 · L. Tonutti24 · R. Trevisan25 · A. A. Turco1 · C. Zamboni26 · G. Riccardi1 · O. Vaccaro1
Abstract Purpose The optimal macronutrient composition of the diet for the management of type 2 diabetes is debated, particularly with regard to the ideal proportion of fat and carbohydrates. The aim of the study was to explore the association of different proportions of fat and carbohydrates
Electronic supplementary material The online version of this article (doi:10.1007/s00394-015-0983-1) contains supplementary material, which is available to authorized users. On behalf of the TOSCA.IT Study Group.
of the diet—within the ranges recommended by different guidelines—with metabolic risk factors. Methods We studied 1785 people with type 2 diabetes, aged 50–75, enrolled in the TOSCA.IT Study. Dietary habits were assessed using a validated food-frequency questionnaire (EPIC). Anthropometry, fasting lipids, HbA1c and C-reactive protein (CRP) were measured. Results Increasing fat intake from