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Letters to the Editor
Irinotecan as a maintenance therapy for hepatoblastoma: A comment E of cells exposed to irinotecan is related to increased degree of genotoxicity.[4] Hence, vitamin status should be addressed in using irinotecan for the treatment of hepatoblastoma.
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DOI: 10.4103/0973-1482.77092
V. Wiwanitkit Wiwanitkit House, Bang Khae, Bangkok, Thailand
PMID: ***
Sir, Several novel therapeutic approaches for the treatment of children with hepatoblastoma are currently available. Irinotecan is a new drug proposed for its effectiveness in highrisk patients with hepatoblastoma.[1] Qayed et al. found that irinotecan can be used as an effective maintenance therapy for hepatoblastoma.[2] However, hepatoblastoma is rare and clinical trials on irinotecan have usually included only a few subjects. Hence, it remains uncertain whether irinotecan is the optimal treatment for hepatoblastoma. Side effects of irinotecan should also be of concern. An important serious side effect of irinotecan is chemotherapy-induced diarrhea that can be a significant problem for patients.[3] For the studies with few subjects, it might be difficult to assess the magnitude of this side effect of irinotecan. Another important side effect is the genotoxicity. It should be noted that increased vitamin A, C and
For Correspondence: V. Wiwanitkit, Wiwanitkit House, Bang Khae, Bangkok, Thailand 10160 E-mail:
[email protected]
REFERENCES 1. Katzenstein HM, Rigsby C, Shaw PH, Mitchell TL, Haut PR, Kletzel M. Novel therapeutic approaches in the treatment of children with hepatoblastoma. J Pediatr Hematol Oncol 2002;24:751-5. 2. Qayed M, Powell C, Morgan ER, Haugen M, Katzenstein HM. Irinotecan as maintenance therapy in high-risk hepatoblastoma. Pediatr Blood Cancer. 2010. 3. Richardson G, Dobish R. Chemotherapy induced diarrhea. J Oncol Pharm Pract 2007;13:181-98. 4. Kontek R, Drozda R, Sliwinski M, Grzegorczyk K. Genotoxicity of irinotecan and its modulation by vitamins A, C and E in human lymphocytes from healthy individuals and cancer patients. Toxicol in Vitrol 2009.
Ameloblastoma mimicking as mucoepidermoid carcinoma on cytology A 30-year-old female presented with a painless left submandibular swelling. The patient gave a history of surgery eight years back in the same region. Previous surgical notes and histopathology sections could not be procured for a review. On examination a submandibular swelling was seen measuring 4×3 cm.
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DOI: 10.4103/0973-1482.77093 PMID: ***
Sir, A mass in the salivary gland region often presents a diagnostic challenge with regard to its site of origin (salivary versus non-salivary), benign or malignant nature, and tissue-specific diagnosis. 588
The smears were hypercellular and showed a mucoid background with debris. There were tight clusters and sheets of hyperchromatic epithelial cells [Figure 1]. Keratinized squamous cells were seen among cells with intercellular cytoplasmic vacuoles containing mucin which stained metachromatically with MGG [Figure 2]. Mitotic figures were absent. On the basis of these cytomorphorphological features from a submandibular
Journal of Cancer Research and Therapeutics - October-December 2010 - Volume 6 - Issue 4
