Leptospira interrogans ... - PLOS

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12 Leptospira interrogans QINLFKKSNPYKAKVISNVLLTPETGTGKRPKKEGEALVHR--------IVLAIDHSA--YPYVIGQSGGVIPPGE-------DPE--KKAK--------84 Leptospira borgpetersenii12 QINLFKKSNPYKAKVISNVLLTPEAGTGKRPKKEGEALVHR--------ITLALDHSA--YPYLIGQSGGVIPPGE-------DPE--KKAK--------84 5 Leptospira biflexa QINLFKKSNPIQAQVLANTRLTPELGKGKRSMREGDAAVHR--------ITIAIDHSV--YPYMIGQSAGIIPPGL-------DPE--KQTK--------77 Bordetella petrii YVNLYTHKTPALATVVGNYRVTDADTDS---------DIHH--------IVLEFGSVP--FPVLEGQSIGILPPGT-------DAQ--GRPH-------Burkholderia phytofirmans YVNLYTHKEPTSATVVGNYRLTDGSTDS---------DIHH--------IVLDFGSMP--FPVLEGQSIGILPPGT-------AAD--GRAH-------Azoarcus evansii YVNLYTPANPITATVTGNYRLTAEDASS---------DIHH--------IVLDFGTTP--FPVLEGQSIGIIPPGV-------DEK--GKPH-------Variovorax paradoxus YTNLFAPKSPTTATVVGNFNCTEAGFDS---------ETHH--------IVLDFGVVP--FPVLEGQSIGIVPPGV-------DAI--GKRH-------19 Toxoplasma gondii AVNTFRPASPLICRVVSVTPVTSKDSSP---------DDSHGEAPQVFSIVLHH-GKQ--LPFVEGQGIGIMPPSRAAQAPVADES--TSQR-------N97 24 Pisum sativum(R) PLNLHKPKEPYTATIVSVERLVGPKAPG---------ETCH--------IVIN-HDGN--VPYWEGQSYGVIPPGE-------NPKKPGSP---------87 25 Oryza sativa(E) PLNLYKPKEPYTATIVSVERLVGPKAPG---------ETCH--------IVID-HGGN--VPYWEGQSYGVIPPGE-------NPKKPGSP---------88 24 Nicotiana tabacum(R) PLNIYKPKEPYTATIVSVERLVGPKAPG---------ETCH--------IVID-HDGN--LPYWEGQSYGVIPPGE-------NPKKPGNP---------87 Thalassiosira pseudonana PVNVYKNKAPFTGKVVSTKRIVGPQATG---------ETCH--------IVID-HQGN--FPYWEGQSWGVIPPGT-------REK-DGKP--------Bigelowiella natans PVNTHKNKAPLTAKVVSVERIVGPKATG---------ETCN--------IVID-HEGK--MPYWEGQSAGVIPPGI-------DPKR-NKP--------Chlamydomona reinhardtii 62 PLNTYSNKAPFKAKVRSVEKITGPKATG---------ETCH--------IIIE-TEGK--IPFWEGQSYGVIPPGT-------KINSKGKE---------125 12 Gloeobacter violaceus PVNIYRPASPFRGKALQNINLTPDDPDN---------DVRH--------VVLDLSGGD--LRYFEGQSIGIVPPGT-------DAQ--GKP---------74 Prochlorococcus marinus 79 PVNIYRPKTPYEGTVIENYSLLKEGAIG---------RVNH--------ITFDLKDSDPFLNYVEGQSIGIMPAGE-------DAN--GKP---------143 28 Spinacia oleracea (L) TVNKFKPKTPYVGRCLLNTKITGDDAPG---------ETWH--------MVFS-HEGE--IPYREGQSVGVIPDGE-------DKN--GKP---------89 22 Pisum sativum(L) VVNKFKPKEPYVGRCLLNTKITGDDAPG---------ETWH--------MVFS-TEGE--VPYREGQSIGIVPDGI-------DKN--GKP---------83 28 Zea mays (L) VTNLYKPKEPYVGRCLLNTKITGDDAPG---------ETWH--------MVFS-TEGK--IPYREGQSIGVIADGV-------DKN--GKP---------89 77 Cyanophora paradoxa PLNLFRPANPYIGKCIYNERIVGEGAPG---------ETKH--------IIFT-HEGK--VPYLEGQSIGIIPPGT-------DKD--GKP---------138 Acaryochloris marina PINIYRPNKPFVGKCISNEELVGPGGIG---------TCRH--------LIFDISAGD--LKYVEGQSIGIIADGT-------DDK--GKP--------Cyanothece PVNIYKPKNPYIGKCVENYPLVAEGGSG---------IVQH--------LTFDISGGD--LHYLEGQSIGIIPPGT-------DDN--GKP--------126 Synechocystis PVNIYRPKTPYIGKVLENYPLVREGAIG---------TVQH--------LTFDLSAGD--LRYLEGQSIGIIPPGE-------DDK--GKP---------188 12 Anabaena variabilis PVNLYRPNAPFIGKVISNEPLVKEGGIG---------IVQH--------IKFDLTGGN--LKYIEGQSIGIIPPGV-------DKN--GKP---------73 Nostoc commune PVNTYRPNAPFIGKVISNEPLVKEGGIG---------IVQH--------LKFDISAGD--LKYIEGQSIGIIPPGL-------DKN--GKP--------Synechococcus elongatus 112PVNIYRPNKPFVGKVLSNEPLVQEGGIG---------VVQH--------LTFDISEGD--LRYIEGQSIGIIPDGT-------DDK--GKP---------174 6 Plasmodium falciparum FINLYTVKNPLKCKIVDKINLVRPNSPN---------EVYH--------LEIN-HNGL--FKYLEGHTCGIIPYYN-------ELD--NNPNNQINKDHN76

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85 Leptospira interrogans ---------------GLADVGYTVRLYSIASPSYSFGMKEDNIEFIIKRDNIYDE---NGNIQFKGVCSNYMCDLKPGDEVTMTGPSGKKFLLPNT--DF164 Leptospira borgpetersenii85 ---------------GLADASYTVRLYSIASPSYSFGMKEDNIEFIIKRDNVYDE---NGNLQFKGVCSNYMCDLKPGDEVIMTGPSGKKFLLPAT--DF164 78 Leptospira biflexa ---------------GLADASYTVRLYSIASPSYSFGQTKDNIEFVVKRDNVYDE---NGNLLHKGVCSNYLCDLKPGDVVTMTGPAGKKFLLPQT--DF157 Bordetella petrii ----------------------HARQYSLASPRDGERAGYNNLSLTVKRVTED-----HQGQPARGVCSNYLCDLAKNDTVQVIGPFGNTFLMPN---HA Burkholderia phytofirmans ----------------------HARQYSIASPRDGERPGYNNVSLTVKRVSQQ------HGDSLDGVCSNYLCDLKKGDVVKVIGPFGGTFLMPN---HP Azoarcus evansii ----------------------LLRMYSVASPRDGERPHYNNLSLTVKRVVED-----HEGNPTRGVASNYVCDLKKGDKVQVTGPYGSTYLMPN---HP Variovorax paradoxus ----------------------HARQYSVASPRNGERPGYNNVSLTVKRVTED-----HQGDPVRGVCSNYVCDLKVGDTVQVVGPFGSSFLMPN---HP 98 Toxoplasma gondii SVQPDGQGQQPTTVASICKRRLLPRIYSIASSRDGDDGCGSTLTLCVKKHIYADPVTGKRDRQKDGICSTYICDAKCGDEVEVTGPVGKALLLPT---ST194 88 Pisum sativum(R) ---------------------HNVRLYSIASTRYGDNFDGKTASLCVRRAVYYDPVTGKEDPSKNGVCSNFLCDSKPGDKIKIAGPSGKIMLLPED--DP164 89 Oryza sativa(E) ---------------------NTVRLYSIASTRYGDSFDGKTASLCVRRAVYYDPETGKEDPTKKGICSNFLCDSKPGDKVQITGPSGKIMLLPED--DP165 88 Nicotiana tabacum(R) ---------------------HNVRLYLIASTRYGDSFDGKTASLCVRRAVYYDPETGKEDPSKNGVCSNFLCDSKPGDKVKITGPSGKIMLLPEE—-IP164 Thalassiosira pseudonana ---------------------HSVRLYSIASSRYGDDFTGNTGSLCVRRATYWCPELKADDPAKKGICSNFLCDTTAGDEVMMTGPAGKVMLMPEE--DP Bigelowiella natans ---------------------YGVRLYSIASTRYGDDFTGKTMTLCVRRATYWDPELGKEDPAKKGVCSNYLCDAKPGTELALTGPAGKVMLMPEE--KP Chlamydomona reinhardtii 126--------------------VPTARLYSIASSRYGDDGDGQTASLCVRRAVYVDPETGKEDPAKKGLCSNFLCDATPGTEISMTGPTGKVLLLPAD---A202 75 Gloeobacter violaceus ---------------------HKLRLYSIASSRIGDNKDGKTVSLCVKRVVYKHP---ETGEIVRGVASNFICDLAPGDDVSITGPTGKTFLLPED---P147 Prochlorococcus marinus 144---------------------HKLRLYSIASTRHGDDYKGNTVSLCVRQLQYE-----KDGETINGVCSTYLCDIKPGDKVKITGPVGKEMLLPDE---E214 90 Spinacia oleracea (L) ---------------------HKLRLYSIASSALGDFGDAKSVSLCVKRLIYTN----DAGETIKGVCSNFLCDLKPGAEVKLTGPVGKEMLMPKD---P161 84 Pisum sativum(L) ---------------------HKLRLYSIASSAIGDFGDSKTVSLCVKRLVYTN----DAGEVVKGVCSNFLCDLKPGSEVKITGPVGKEMLMPKD---P155 90 Zea mays (L) ---------------------HKVRLYSIASSAIGDFGDSKTVSLCVKRLIYTN----DAGEIVKGVCSNFLCDLQPGDNVQITGPVGKEMLMPKD---P161 139 Cyanophora paradoxa ---------------------HKLRLYSIASTRHGDFGDDKTVSLSVKRLEYTD----ANGNLVKGVCSNYLCDLKPGDEVMITGPVGTTMLMPED---Q210 Acaryochloris marina ---------------------HKIRLYSIASAHRGDYLDDKTVSLCVRQLEYPDP---DTGKTVYGVCSSFLCNLKPGDDVKITGPVGKEMLLPDD---P Cyanothece ---------------------HKLRLYSIASTRHGDKLDDKTVSLCVRQLEYQHP---ETNETVYGVCSTHLCNLEVGADVAITGPVGKEMLLPDD---E 189 Synechocystis ---------------------HKLRLYSIASTRHGDFGDDKTVSLCVRQLEYQN----EAGETVQGVCSTYLCNIKEGDDIAITGPVGKEMLLPPD---E260 74 Anabaena variabilis ---------------------EKLRLYSIASTRHGDDVDDKTISLCVRQLEYKHP---ESGETVYGVCSTYLTHIEPGSEVKITGPVGKEMLLPDD---P147 Nostoc commune ---------------------EKLRLYSIASTRHGDDVDDKTVSLCVRQLEYKHP---ESGETVYGVCSTHLCFLEPGADVKITGPVGKEMLLPND---P Synechococcus elongatus 175---------------------HKLRLYSIASTRHGDHVDDKTVSLCVRQLQYQN----EAGETINGVCSTFLCGLKPGDDVKITGPVGKEMLLPAD---T246 77 Plasmodium falciparum IINTTNHTNHNNIALSHIKKQRCARLYSISSSNN-----MENLSVAIKIHKYEQTEN-APNITNYGYCSGFIKNLKINDDIYLTGAHG-YFNLPNDAIQK170

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165 Leptospira interrogans SGDIMFLATGTGIAPFIGMSEELLEHKLI----------------------KFTGNITLVYGAPYSDELVMMDYLKGLESKH-KNF-KLITAISREEKNS240 Leptospira borgpetersenii165EKDIMFLATGTGIAPFIGMSEELLEHKLI----------------------KFTGNITLVYGAPYSDELVMMDYLRGLESKH-KNF-KLITAISREEKNP240 158 Leptospira biflexa SGDIFFFATGTGISPFLGMVEELLVQKLI----------------------QFQGNLWLIYGAPYSDEIVLRDYFEDKTKEF-SNF-HFVTAISREEKNS232 Bordetella petrii RANLMMICTGTGSAPMRAMTERCRRRIER----------------------GTNGRLMLFFGARTQRELPYFGPLMKLPRDFI----DINLALSRDASQP Burkholderia phytofirmans NSHLLMICTGTGSAPMRAMTEYRRRRRLK----------------------GATGKLMLFFGARTKEELPYFGPLTNLPKDFI----DTNLAFSRTPGQP Azoarcus evansii GSSIMMICTGTGSAPMRAMTERRRRRMDR----------------------KEGGELVLFFGARAPEELPYFGPLQKLPKEFI----DINFAFSRVPGEP Variovorax paradoxus RSHIVMICTGTGSAPMRAMTEWRRRLR--------------------KSGKFEGGKLMLFFGARTQQELPYFGPLQSLPKDFI----DINLAFSRTPGQP 195 Toxoplasma gondii ETPLVMLATGTGVAPFRSHLQALRRKLLSAGGP------------SAAQP-ANRPKVLLFIGARTAAAVPYMNEWRDIEAQRDGNFVDIHFALSRQMKNP281 165 Pisum sativum(R) NATHIMIATGTGVAPYRGYLRRMFMESV-------------------PTF-KFGGLAWLFLGVANVDSLLYDDEFTKYLKDYPDNF-RYNRALSREEKNK243 166 Oryza sativa(E) NATHIMIATGTGVAPYRGYLRRMFMEDV-------------------PSF-KFGGLAWLFLGVANTDSLLYDEEFTNYLQQYPDNF-RYDKALSREQKNK244 165 Nicotiana tabacum(R) NATHIMIGTGTGVAPFRGYLRRMFMESV-------------------PT--KFNGLAWLFLGVANTDSLLYDDEFTKYLNDYPGNF-RYDRALSREQKNN242 Thalassiosira pseudonana KTDYIMVATGTGIAPFRGFVRRLFFEST-------------------PAAKAYQGQAWLFLGVANSDALLYDDEFQEAKSKFPDNF-RLDYALSREQNNK Bigelowiella natans ETPIIMLATGTGIAPYRGFLRRLFVENT-------------------EAAEKFKGLAWLFLGVANSDALLYDEDWKAMQEKYPEKF-RYDVALSREQKNK Chlamydomona reinhardtii 203NAPLICVATGTGIAPFRSFWRRCFIENV-------------------PSY-KFTGLFWLFMGVGNSDAKLYDEELQAIAKAYPGQF-RLDYALSREQNNR281 148 Gloeobacter violaceus STNLVLIATGTGIAPFRAFLRRIYDEM---------------------DT-PWQGKVWLFFGMQNSNSYLYQDELAGYTAK--GDF-EIVEAISREQKNA222 Prochlorococcus marinus 215DANIVMLATGTGIAPMRAYLRRMFEATEKE----------------KNKW-NFKGKAWLFMGAPKSANLLYEEDLQRYLTDYPDNF-TYTKAISREQQNT296 162 Spinacia oleracea (L) NATIIMLGTGTGIAPFRSFLWKMFFEKH-------------------DDY-KFNGLAWLFLGVPTSSSLLYKEEFEKMKEKAPDNF-RLDFAVSREQTNE240 156 Pisum sativum(L) NATVIMLGTGTGIAPFRSFLWKMFFEKH-------------------EDY-QFNGLAWLFLGVPTSSSLLYKEEFEKMKEKAPENF-RLDFAVSREQVND234 162 Zea mays (L) NATIIMLATGTGIAPFRSFLWKMFFEKH-------------------DDY-KFNGLGWLFLGVPTSSSLLYKEEFGKMKERAPENF-RVDYAVSREQTNA240 211 Cyanophora paradoxa SATIIMLATGTGIAPFRSFLRRMFEETH-------------------ADY-KFNGLAWLFLGVPTSSTLLYREELEKMQKANPNNF-RLDYAISREQTDS289 Acaryochloris marina NANIIMLGTGTGIAPFRSFLWHLFKENEDANANPFWLPKLLGWVKPSDKP-KFNGKTWLIFGVATTPNILYNKDLEDLQRRYPDNF-RLTKAISREQKNP Cyanothece DANIVMLATGTGIAPFRAFLWRMFFEKH-------------------EDY-KFKGKSWLIFGVPYTANILYKDKLEEIQTNYPDNF-ELTYAISREQKNS 261 Synechocystis DANIVMLATGTGIAPFRAFLWRMFKEQH-------------------EDY-KFKGLAWLIFGIPKSENILYKDDLEKMAAEFPDNF-RLTYAISREQQNA339 148 Anabaena variabilis EANVIMLATGTGIAPMRTYLWRMFKDAERA-AN--------------PEY-QFKGFSWLVFGVPTTPNILYKEELEEIQQKYPDNF-RLTYAISREQKNP220 Nostoc commune DANVIMLATGTGIAPMRAYLWRQFKDAERA-AN--------------PEY-QFKGFSWLIFGVPTTPNLLYKEELEEIQQKYPDNF-RLTAAISREQKNP Synechococcus elongatus 247DANVIMMGTGTGIAPFRAYLWRMFKDNERA-IN--------------SEY-QFNGKAWLIFGIPTTANILYKEELEALQAQYPDNF-RLTYAISREQKNE329 171 Plasmodium falciparum NTNFIFIATGTGISPYISFLKKLFAYDKNNLYN--------------RNS-NYTGYITIYYGVYNEDSILYLNELEYFQKMYPNNI-NIHYVFSYKQ-NS252

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241 Leptospira interrogans FDGGRMYISHRVREQAEAVKKILNGGGRFYICGGPKGMEKGVIEEIQKISGNTGT-YEEFKHHLEGAHQLFVETY314 Leptospira borgpetersenii241FDGGRMYISHRVREQAEIVKKILNGGGRFYICGGPKGMEKGVIEEIQKTAEHAGT-YEEFKHHLEGAHQLFVETY314 233 Leptospira biflexa FDGGKMYITHRAKENAEAIKNAVNGNGKFYICGGPKGMEKGVIQEIMSACGTDST-YEAFKKHLEEKEQLFVETY307 Bordetella petrii ----RRYVQDLIRERAADVLDLLADPNTCIYVCGLKGMESGVLDALRDVVVQAGQDWTILHAALRREGRLHFETY Burkholderia phytofirmans ----KRYVQDAMRERAVDVAHMLKDDNTHIYVCGLKGMEDGVLQALKEIGERHQLDWEALWVKLKKEGRLHLETY Azoarcus evansii ----KRYVQDAIRERADKVFQMLQDDNCYIYICGLKGMEAGVLEAFRDICRAKGADWDALRPQLLSKARFHVETY Variovorax paradoxus ----RRYVQDLMRERAADLAALLKDGASHFYVCGLKSMEEGVVLALRDVAKEAGLDWDTVGAALKREGRLHLETY 282 Toxoplasma gondii -QGKKLYIQDVVWQEREKVWKALDRDGGHLYACGLKNMMVGVHEVLGNMAEEKGLPRDHLASLLKHQRRWHVEVY355 244 Pisum sativum(R) -NGGKMYVQDKIEEYSDEIFKLL-DNGAHIYFCGLRGMMPGIQETLKRVAEKRGESWEEKLSQLKKNKQWHVEVY316 245 Oryza sativa(E) -NGGKMYVQDKIEEYSDEIFKLL-DGGAHIYFCGLKGMMPGIQDTLKRVAEQRGESWEQKLSQLKKNKQWHVEVY317 243 Nicotiana tabacum(R) -KGGKMYVQDKIEEYSDEIFKLL-DEGAHIYFCGLKGMMPGIQDTLKRVAERRGESWEQKLSQLKKNKQWHVEVY315 Thalassiosira pseudonana -KGGKMYIQDKVEEYADEVFNKL-NNGAHIYFCGLKGMMPGIQDMLAEVCKSKGLDYDEWIKELKGKKQWHVEVY Bigelowiella natans -SGGKMYIQDKVEEYGKEVFELM-NLGAHIYFCGLKGMMPGVLGAMESVAKSQGVNWEETLQKWKKAGQWHVEVY Chlamydomona reinhardtii 282-KGGKMYIQDKVEEYADEIFDLL-DNGAHMYFCGLKGMMPGIQDMLERVAKEKGLNYEEWVEGLKHKNQWHVEVY354 223 Gloeobacter violaceus -QGGRMYVQHRIAEHAAALWELISGGNTYTYICGLKGMEDGIDDAFTAAAAAKDTVWKDYRYNLKQSGFWHVETY296 Prochlorococcus marinus 297-KGGRMYIQDRVLESANELFNMIEDEKTHIYLCGLKGMEPGIDEAMTKAAEEKGLNWSELRPQLKKAGRWHVETY370 241 Spinacia oleracea (L) -KGEKMYIQTRMAQYAVELWEMLKKDNTYFYMCGLKGMEKGIDDIMVSLAAAEGIDWIEYKRQLKKAEQWNVEVY314 235 Pisum sativum(L) –KGEKMYIQTRMAQYAEELWELLKKDNTFVYMCGLKGMEKGIDDIMVSLAAKDGIDWIEYKRTLKKAEQWNVEVY308 241 Zea mays (L) -AGERMYIQTRMAEYKEELWELLKKDNTYVYMCGLKGMEKGIDDIMVSLAEKDGIDWFDYKKQLKRGDQWNVEVY314 290 Cyanophora paradoxa -KGEKMYIQNRIAEYANEFWNMIQKPNTFVYMCGLRGMEDGIQQCMEDIAKANGTTWDAVVKGLKKEKRWHVETY363 Acaryochloris marina -EGGRMYIQHRVAEHAEELWQMIQQENTHTYICGLKGMEKGIDEALSAVASKDGVNWSDYQREMKKAHRWHVETY Cyanothece -EGGRMYIQHRVAEQAEKLWNMLQDPKTHLYMCGLKGMEAGIEEGLKPFAEKQGVEWSDFVKGLKKEHRWHVEVY 340 Synechocystis -EGGRMYIQHRVAENAEELWNLMQNPKTHTYMCGLKGMEPGIDEAFTALAEQNGKEWTTFQREMKKEHRWHVETY413 221 Anabaena variabilis -QGGRMYIQDRVAEHADELWQLIKNQKTHTYICGLRGMEEGIDAALSAAAAKEGVTWSDYQKDLKKAGRWHVETY304 Nostoc commune -QGGRMYIQDRVAEHADELWQLIKNEKTHTYICGLRGMEEGIDAALTGAAAKEGVTWSDYQKELKKAHRWHVETY Synechococcus elongatus 330-AGGRMYIQDRVAEHADEIWNLLKDEKTHVYICGLRGMEDGIDQAMTVAAAKEDVVWSDYQRTLKKAGRWHVETY403 253 Plasmodium falciparum -DATSFYVQDEIYKRKTEFLNLFNNYKCELYICGHKSIRYKVMDILK----------SHDQFDEKKKKRVHVEVY316