Spinal tanycytic ependymoma associated with neurofibromatosis type 2. Santiago Cepeda1, Aurelio Hernández-. LaÃn2, Pablo M. Munárriz1, Miguel Ãngel.
Clinical Neuropathology, DOI 10.5414/NP300704 – Letter to the editor
LETTER TO THE EDITOR Spinal tanycytic ependymoma associated with Letter ©2014 Dustri-Verlag Dr. K. Feistle ISSN 0722-5091 DOI 10.5414/NP300704 e-pub: February 5, 2014
Santiago Cepeda1, Aurelio HernándezLaín2, Pablo M. Munárriz1, Miguel Ángel Martínez González2, and Alfonso Lagares1 1Department
of Neurosurgery, and of Pathology, Hospital Universitario 12 de Octubre, Madrid, Spain
2Department
NF-2
Figure 1. Sagittal magnetic resonance imaging (MRI) of cervical spine. A: Contrast enhanced T1weighted image showing well demarcated enhancing intramedullary tumors at C1 – C2 and C4 – C5 level. B: T2-weighted image shows an iso-intense solid component.
Figure 2. A, B, C: Elongated tumor cells with long cytoplasmic processes arranged in a fascicular pattern (H & E stain × 10; × 40; × 63). D: Intracytoplasmic dot-like immunoreactivity (head arrows; EMA × 63). E, F: Electron micrograph of the tumor showing intercellular junctions (white arrow) and sporadic cilia (white head arrow; × 5,000).
Table 1.
Reported cases of spinal tanycytic ependymomas.
Author/year
Sex
Age
Level
Treatment
Follow-up
F
38
C6 – D3
Subtotal resection
ND
F
46
T7 – L2
ND
ND
M
45
C1 – D1
ND
ND
M
17
C1 – C3
ND
ND
F
36
C1 – C6
Subtotal resection
ND
F
35
T10 – T11
ND
ND
Spaar 1986 [18]
M
32
D6 – T7
Total resection
Langford and Barré 1997 [7]
F
52
C6 – C7
Total resection
Death due to post-operative complication No recurrence after 2 years
Dvoracek and Kirby 2001 [8]
F
31
L5 – S1
Subtotal resection
No recurrence after 8 m
Kwano et al. 2001 [9]
M
45
T3 – T4
Total resection
No recurrence after 9 years
F
55
C7 – T2
Total resection
No recurrence after 9 years
F
36
C3 – C6
Total resection
No recurrence after 2 years
Kobata et al. 2001† [3]
M
30
T6 – T11
Total resection
No recurrence after 6 m
Ueki et al. 2001† [5]
F
13
C7 – T2
Total resection
ND
Boccardo et al. 2003 [10]
F
39
C5-C6
Total resection
No recurrence after 2 years
Ito et al. 2005 [11]
M
62
CMJ
Subtotal resection
No recurrence after 1 year
Sato et al. 2005 [12]
M
58
C2 – C4
Subtotal resection
No recurrence after 2 years
Mohindra et al. 2008 [13]
F
10
Filum
Total resection
No recurrence after 1 year
Shintaku et al. 2009 [14]
F
55
Filum
Total resection
No recurrence after 6 m
M
43
T2 – T5
Subtotal resection
No recurrence after 10 m
Friede and Pollak 1978 [2]
Bong-Suk 2010† [19]
F
16
C1
Subtotal resection
No recurrence after 2 years
Ishihama et al. 2011 [15]
F
40
T10 – T11
Total resection
No recurrence after 16 m
Radhakrishnan et al. 2011 [16]
M
44
T10 – L1
Total resection
ND
Krisht and Schmidt 2013 [17]
M
50
C3 – C5
Total resection
No recurrence after 16 m
ND = not described; CMJ = cervicomedullary junction; C = cervical; T = thoracic; L = lumbar; S = sacral; † matosis type 2.
Figure 3. Morphological comparison between tumor cells and fetal tanycytes. A: Spindle cells in tanycytic ependymoma with immunoreactivity to GFAP (black head arrows; GFAP × 63) B: Tanycytes observed in the ependymal lining in a 25week fetus, radial basal processes that extend into the subventricular zone (black arrows; GFAP × 63).
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36(9): Radhakrishnan N, Nair NS, Hingwala DR, Kapilamoorthy TR, Radhakrishnan VV. 114: Krisht KM, Schmidt MH.
Spaar FW, Ahyai A, Spaar U, Gazsó L, Zimmermann A
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