LETTER TO THE EDITOR Spinal tanycytic ependymoma associated ...

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Spinal tanycytic ependymoma associated with neurofibromatosis type 2. Santiago Cepeda1, Aurelio Hernández-. Laín2, Pablo M. Munárriz1, Miguel Ángel.
Clinical Neuropathology, DOI 10.5414/NP300704 – Letter to the editor

LETTER TO THE EDITOR Spinal tanycytic ependymoma associated with Letter ©2014 Dustri-Verlag Dr. K. Feistle ISSN 0722-5091 DOI 10.5414/NP300704 e-pub: February 5, 2014

Santiago Cepeda1, Aurelio HernándezLaín2, Pablo M. Munárriz1, Miguel Ángel Martínez González2, and Alfonso Lagares1 1Department

of Neurosurgery, and of Pathology, Hospital Universitario 12 de Octubre, Madrid, Spain

2Department

NF-2

Figure 1. Sagittal magnetic resonance imaging (MRI) of cervical spine. A: Contrast enhanced T1weighted image showing well demarcated enhancing intramedullary tumors at C1 – C2 and C4 – C5 level. B: T2-weighted image shows an iso-intense solid component.

Figure 2. A, B, C: Elongated tumor cells with long cytoplasmic processes arranged in a fascicular pattern (H & E stain × 10; × 40; × 63). D: Intracytoplasmic dot-like immunoreactivity (head arrows; EMA × 63). E, F: Electron micrograph of the tumor showing intercellular junctions (white arrow) and sporadic cilia (white head arrow; × 5,000).

Table 1.

Reported cases of spinal tanycytic ependymomas.

Author/year

Sex

Age

Level

Treatment

Follow-up

F

38

C6 – D3

Subtotal resection

ND

F

46

T7 – L2

ND

ND

M

45

C1 – D1

ND

ND

M

17

C1 – C3

ND

ND

F

36

C1 – C6

Subtotal resection

ND

F

35

T10 – T11

ND

ND

Spaar 1986 [18]

M

32

D6 – T7

Total resection

Langford and Barré 1997 [7]

F

52

C6 – C7

Total resection

Death due to post-operative complication No recurrence after 2 years

Dvoracek and Kirby 2001 [8]

F

31

L5 – S1

Subtotal resection

No recurrence after 8 m

Kwano et al. 2001 [9]

M

45

T3 – T4

Total resection

No recurrence after 9 years

F

55

C7 – T2

Total resection

No recurrence after 9 years

F

36

C3 – C6

Total resection

No recurrence after 2 years

Kobata et al. 2001† [3]

M

30

T6 – T11

Total resection

No recurrence after 6 m

Ueki et al. 2001† [5]

F

13

C7 – T2

Total resection

ND

Boccardo et al. 2003 [10]

F

39

C5-C6

Total resection

No recurrence after 2 years

Ito et al. 2005 [11]

M

62

CMJ

Subtotal resection

No recurrence after 1 year

Sato et al. 2005 [12]

M

58

C2 – C4

Subtotal resection

No recurrence after 2 years

Mohindra et al. 2008 [13]

F

10

Filum

Total resection

No recurrence after 1 year

Shintaku et al. 2009 [14]

F

55

Filum

Total resection

No recurrence after 6 m

M

43

T2 – T5

Subtotal resection

No recurrence after 10 m

Friede and Pollak 1978 [2]

Bong-Suk 2010† [19]

F

16

C1

Subtotal resection

No recurrence after 2 years

Ishihama et al. 2011 [15]

F

40

T10 – T11

Total resection

No recurrence after 16 m

Radhakrishnan et al. 2011 [16]

M

44

T10 – L1

Total resection

ND

Krisht and Schmidt 2013 [17]

M

50

C3 – C5

Total resection

No recurrence after 16 m

ND = not described; CMJ = cervicomedullary junction; C = cervical; T = thoracic; L = lumbar; S = sacral; † matosis type 2.

Figure 3. Morphological comparison between tumor cells and fetal tanycytes. A: Spindle cells in tanycytic ependymoma with immunoreactivity to GFAP (black head arrows; GFAP × 63) B: Tanycytes observed in the ependymal lining in a 25week fetus, radial basal processes that extend into the subventricular zone (black arrows; GFAP × 63).

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36(9): Radhakrishnan N, Nair NS, Hingwala DR, Kapilamoorthy TR, Radhakrishnan VV. 114: Krisht KM, Schmidt MH.

Spaar FW, Ahyai A, Spaar U, Gazsó L, Zimmermann A

References Horstmann E.

5:

39: Lim BS, Park SQ, Chang UK, Kim MS

Friede RL, Pollak A. 37: Kobata H, Kuroiwa T, Isono N, Nagasawa S, Ohta T, Tsutsumi A. 20: Lim BS, Park SQ, Chang UK, Kim MS. 17: Ueki K, Sasaki T, Ishida T, Kirino T.

41: Sgouros S, Malluci CL, Jackowski A.

10: Langford LA, Barré GM. 21: Dvoracek MA, Kirby PA. 24: Kawano N, Yagishita S, Oka H, Utsuki S, Kobayashi I, Suzuki S, Tachibana S, Fujii K. 101: Boccardo M, Telera S, Vitali A. 49: Ito T, Ozaki Y, Nakagawara J, Nakamura H, Tanaka S, Nagashima K.

22: Sato K, Kubota T, Ishida M, Handa Y. 45: Mohindra S, Bal A, Singla N. 23: Shintaku M, Nagata N, Itoh H. 26: Ishihama H, Nakamura M, Funao H, Ishii K, Matsumoto M, Toyama Y, Chiba K.

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