OBES SURG (2013) 23:1790–1798 DOI 10.1007/s11695-013-1033-9
ORIGINAL CONTRIBUTIONS
Long-term Changes in Leptin, Chemerin and Ghrelin Levels Following Different Bariatric Surgery Procedures: Roux-en-Y Gastric Bypass and Sleeve Gastrectomy Ximena Terra & Teresa Auguet & Esther Guiu-Jurado & Alba Berlanga & Josep Maria Orellana-Gavaldà & Mercè Hernández & Fàtima Sabench & Jose Antonio Porras & Jordi Llutart & Salomé Martinez & Carmen Aguilar & Daniel Del Castillo & Cristóbal Richart Published online: 7 July 2013 # Springer Science+Business Media New York 2013
Abstract Background Different studies have evaluated changes in adipo/cytokine levels after bariatric surgery and have given conflicting results. The adipo/cytokines, leptin and chemerin, and the orexigenic hormone, ghrelin, have been shown to play a role in the regulation of metabolism and appetite. The aims of our study were to test the levels of these molecules after bariatric surgery and to compare the results between Roux-enY gastric bypass and laparoscopic sleeve gastrectomy. Methods We analysed circulating levels of chemerin, ghrelin and leptin in 30 morbidly obese women (body mass index of >40 kg/m2). Subjects were studied at three time points: baseline (before the surgery started), and after 6 and 12 months. Results After surgery, chemerin (baseline, 95.03±23.79; after 12 months, 76.80±21.51; p=0.034) and leptin levels (baseline, X. Terra and T. Auguet contributed equally to this work. X. Terra : T. Auguet : E. Guiu-Jurado : A. Berlanga : J. M. Orellana-Gavaldà : C. Aguilar : C. Richart Grup d’Estudi de Malalties Metabòliques Associades a Insulin Resistència (GEMMAIR), Departament de Medicina i Cirurgia, Universitat Rovira i Virgili (URV), Tarragona, Spain T. Auguet : J. A. Porras : J. Llutart : C. Richart Servei Medicina Interna, Hospital Universitari Joan XXIII Tarragona, Tarragona, Spain M. Hernández : F. Sabench : D. Del Castillo Servei de Cirurgia, Hospital Sant Joan de Reus, Tarragona, Spain S. Martinez Servei Anatomia Patològica, Hospital Universitari Joan XXIII Tarragona, Tarragona, Spain T. Auguet (*) Department of Internal Medicine, Hospital Universitari de Tarragona Joan XXIII, Universitat Rovira i Virgili, c/ Mallafré Guasch, 4, 43007 Tarragona, Catalonia, Spain e-mail:
[email protected]
248.17±89.16; after 12 months, 63.85±33.48; p40 kg/m2) and 60 women whose weight was
1791
normal (controls; BMI,
