Low Ratio of Androstenedione to Testosterone in ... - Clinical Chemistry

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Nov 6, 1991 - To 1 mL of plasma 10000 dpm of. [1,2,6,7-3H]androst-4-ene-3,17-dione. [specific activity. 80-110 kCilmol (no. TRK454,. Ainersham; Aylesbury,.
CLIN.CHEM.38/9, 1819-1823

(1992)

Low Ratio of Androstenedione to Testosterone in Plasma and Saliva of Hirsute Women L. M. J. W. Swinkeis,’

H.

J. C.

van Hoof,’

H. A. Ross,2 A. G. H. Smals,2 and T.

To gain insight into the passage of androstenedione (A4) through the salivary gland, we measured concentrations of plasma total (TA.), free (FA4), and salivary (SA4) androstenedione during administration of dexamethasone and synthetic corticotropin to control subjects and hirsute women and compared these data with plasma total (TT), free (Fr), and salivary testosterone (ST) concentrations. TA4 and FA4 were significantly lower in control subjects throughout (0, 15, 45, and 75 mm) (P