Lp(a) LipoproteinConcentration in Serum of ... - Clinical Chemistry

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trations in serum of three patients with primary amyloidosis and nephrosis syndrome. Our results indicate a regulatory role of the kidney in the metabolism of ...

DLIN. CHEM. 35/10,

2121-2123 (1989)

Lp(a) Lipoprotein Concentration in Serum of Patients with Heavy Proteinuria of Different Origin sWan Karadl,1 L#{243}szI#{243} Romlcs,1 G#{224}bor P#{225}los,’ J#{243}zsef Dom#{243}n,2 Ilona Kaszas,3 Arpad Hesz,1 and Gerhard M. Kostner4

We measuredserumcholesterol,triglyceride,and lipoprotein Lp(a) concentrationsin serum of 37 patients with massive proteinuria of different origin, comparing values with those for age- and sex-matched controls and finding significantlyin-

creased Lp(a) concentrationin the total group of patients compared with controls. Lp(a) concentrationwas not correlated with serum cholesterol, triglycende, serum creatinine, daily urinary protein loss, or selectivity index. Selecting the

patientsaccordingto their histologicaldiagnosisobtainedby renal needle biopsy, we found divergent results in seven patientswith minimalchange disease (MCD) compared with 11 patients with membranoproliferativeglomerulonephritis. Lp(a) in MCD patientsdid not differ fromthat in controls(101 ± 102 and 90 ± 115 mg/L) and correlatedpositivelywithtotal daily urinary proteinloss (r = 0.7962, P 300 mg/L was fourfold that for the controls. We found no correlation between Lp(a) concentration and urinary protein loss, selectivity index, or endogenous creatinine clearance in the total group of patients. In contrast, in the seven patients with minimal change disease (MCD) there was a significant positive correlation between urinary protein and

Lp(a)

concentration

(Figure

1). In the

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Results

excretion

.7,

D

3

C

3

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‘V

a

0

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400

(.9/I.)

Lp(a)

Fig.1. Correlation between daily urinaryproteinexcretionand Lp(a) concentration inserum of patients with minimalchangedisease(n = 7; r = 0.7962; P

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