Magnetic nanoparticles-based drug and gene delivery systems for the ...

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delivery systems have been emerged for treatment of cystic fibrosis and lung cancer. This review ... delivery is at the leading edge of the rap- idly developed ...
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Magnetic nanoparticles-based drug and gene delivery systems for the treatment of pulmonary diseases

Magnetic nanoparticles (MNPs) have gained much attention due to their unique properties such as biocompatibility and biodegradability as well as magnetic and heat-medicated characteristics. Due to these inherent properties, MNPs have been widely used in various biomedical applications including targeted drug delivery and hyperthermia-based therapy. Hyperthermia is a promising approach for the thermal activation therapy of several diseases, including pulmonary diseases. Additionally, due to their large loading capacity and controlled release ability, several MNP-based drug delivery systems have been emerged for treatment of cystic fibrosis and lung cancer. This review provides an overview on the unique properties of MNPs and magneticmediated hyperthermia with emphasis on the recent biomedical applications of MNPs in treatment of both lung cancer and cystic fibrosis.

Ibrahim M El-Sherbiny*,1, Nancy M Elbaz†,1, Mohammed Sedki†,1, Abdulaziz Elgammal1 & Magdi H Yacoub2 Nanomaterials Laboratory, Center for Materials Science, Zewail City of Science & Technology, 6th October City, 12588 Giza, Egypt 2 Harefield Heart Science Centre, National Heart & Lung Institute, Imperial College, London, UK *Author for correspondence: Tel.: +20 238 540 407 Fax: +20 238 517 181 [email protected] † Authors contributed equally 1

First draft submitted: 24 September 2016; Accepted for publication: 9 December 2016; Published online: 12 January 2017 Keywords:  cystic fibrosis • hyperthermia • iron oxide nanoparticles • lung cancer • magnetic nanoparticles • targeted drug delivery

Magnetic nanoparticles (MNPs)-based drug delivery is at the leading edge of the rap-

10.2217/nnm-2016-0341 © 2017 Future Medicine Ltd

idly developed approaches for the treatment and diagnosis of various diseases. In this

Nanomedicine (Lond.) (Epub ahead of print)

part of

ISSN 1743-5889