Immunosuppressive Natural Product Triptolide. Denis Vasilievich Titov1, Benjamin Gilman3, QingLi He1, Shridhar Bhat1,. WoonKai Low1, Michael Smeaton4, ...
Sign In
Marked List (0)
My EndNote Web
My ResearcherID
My Citation Alerts
My Journal List
My Saved Searches Log Out
Search
Author Search
Cited Reference Search
Advanced Search
Help
Search History
Web of Science ® Record 12 of 22
< < Back t o result s list
(0)
Sa ve to :
Re co rd fro m Web o f Science ®
mo re o p tio n s
Times Cited: 0
Mechanistic Studies of the Antiprolif erative and Immunosuppressive Natural Product Triptolide
Th is a rticle h a s b e e n cite d 0 time s in We b o f Kn o wle d g e .
Aut hor(s): Titov, DV (Titov, Denis Vasilievich)[ 1 ] ; Gilman, B (Gilman, Benjamin)[ 3 ] ; He, QL (He, QingLi)[ 1 ] ; Bhat, S (Bhat, Shridhar)[ 1 ] ; Low, WK (Low, WoonKai)[ 1 ] ; Smeaton, M (Smeaton, Michael)[ 4 ] ; Demain, A (Demain, Arnold)[ 5 ] ; Miller, P (Miller, Paul)[ 4 ] ; Kugel, J
Cited References: 0 Additional information
(Kugel, Jennifer)[ 3 ] ; Goodrich, J (Goodrich, James)[ 3 ] ; Liu, JO (Liu, Jun O.)[ 1,2 ] Source : FASEB JOURNAL Volume : 25 Publishe d: APR 2011
View the journal's impact f act or (in Journal Citation Reports ® )
T ime s Cit e d: 0 (from Web of Science) Cit e d Re f e re nce s: 0 Conf e re nce : Experimental Biology Meeting 2011 Locat ion: Washington, DC Dat e : APR 09 13, 2011 Sponsor(s): Amer Assoc Anatomists (AAA); Amer Physiolog Soc (APS); Amer Soc Biochem & Mol Biol (ASBMB); Amer Soc Investigat Pathol (ASIP); Amer Soc Nutrit (ASN); Amer Soc Pharmacol & Expt Therapeut (ASPET)
Suggest a correction If you would like to improve the quality of the data in this record, please suggest a correction.
Acce ssion Numbe r: WOS:000310708402954 Docume nt T ype : Meeting Abstract
Language : English Addre sse s: [ 1 ] Johns Hopkins Univ, Sch Med, Dept Pharmacol & Mol Sci, Baltimore, MD 21205 USA [ 2 ] Johns Hopkins Univ, Sch Med, Dept Oncol, Baltimore, MD 21205 USA [ 3 ] Univ Colorado, Dept Chem & Biochem, Boulder, CO 80309 USA [ 4 ] Johns Hopkins Univ, Dept Biochem & Mol Biol, Bloomberg Sch Publ Hlth, Baltimore, MD USA [ 5 ] Drew Univ, Charles A Dana Res Inst Scientists Emeriti RISE, Madison, NJ 07940 USA Publishe r: FEDERATION AMER SOC EXP BIOL, 9650 ROCKVILLE PIKE, BETHESDA, MD 208143998 USA We b of Scie nce Cat e gorie s: Biochemistry & Molecular Biology; Biology; Cell Biology Re se arch Are as: Biochemistry & Molecular Biology; Life Sciences & Biomedicine Other Topics; Cell Biology IDS Numbe r: 032IE ISSN: 08926638 Record 12 of 22
< < Back t o result s list
Re co rd fro m Web o f Science ®
Out put Re cord St e p 1: Select content. Authors, Title, Source
Abstract
St e p 2: Select destination. [Le a rn a b o u t sa vin g to b ib lio g ra p h ic so ftwa re ]
Sa ve to :
(The FASEB Journal. 2011;25:569.3) © 2011 FASEB
569.3
Mechanistic Studies of the Antiproliferative and Immunosuppressive Natural Product Triptolide Denis Vasilievich Tit ov1, Benjamin Gilman3, Qing Li He 1, Shridhar Bhat 1, Woon Kai Low1, Michael Smeat on4, Arnold Demain5, Paul Miller4, Jennif er Kugel 3, James Goodrich3 and Jun O Liu1,2 1 De p a rtme n t o f Ph a rma co lo g y a n d M o le cu la r Scie n ce s 2 De p a rtme n t o f On co lo g y, Jo h n s Ho p kin s Un ive rsity Sch o o l o f M e d icin e , Ba ltimo re , M D 3 De p a rtme n t o f Ch e mistry a n d Bio ch e mistry, Un ive rsity o f Co lo ra d o , Bo u ld e r, CO 4 De p a rtme n t o f Bio ch e mistry a n d M o le cu la r Bio lo g y, Blo o mb e rg Sch o o l o f Pu b lic He a lth , Jo h n s
Ho p kin s Un ive rsity, Ba ltimo re , M D 5 Ch a rle s A Da n a Re se a rch In stitu te fo r Scie n tists Eme riti (RISE), Dre w Un ive rsity, M a d iso n , NJ
Triptolide is a structurally unique diterpene triepoxide purified from Tripterygium wilfordii Hook F, commonly known as Lei Gong Teng or Thunder God Vine, a medicinal plant whose extracts have been used in traditional Chinese medicine for treating a wide variety of diseases from inflammation to arthritis for centuries. Preclinical studies have revealed that triptolide is effective against cancer, collagen induced arthritis, skin allograft rejection and bone marrow transplantation in animal models. Triptolide and derivatives have entered human clinical trials for cancer among other diseases. Its molecular mechanism of action, however, has remained largely elusive to date. Here we report studies that further enhance our understanding of the mechanism of action of triptolide. We used a variety of biochemical and cell biology methods to identify new cellular pathways affected by the drug. Our results should help explain the ability of triptolide to inhibit cell proliferation.