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Received: 28 June 2016 Accepted: 12 December 2016 DOI: 10.1111/micc.12345
ORIGINAL ARTICLE
Melatonin pretreatment improves gastric mucosal blood flow and maintains intestinal barrier function during hemorrhagic shock in dogs Christian Vollmer1 | Andreas P. M. Weber2 | Martin Wallenfang1 | Till Hoffmann3 | Tabea Mettler-Altmann4 | Richard Truse1 | Inge Bauer1 | Olaf Picker1 | Alexander M. Mathes1,5 1 Department of Anesthesiology, Düsseldorf University Hospital, Düsseldorf, Germany
Abstract
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Objective: Melatonin improves hepatic perfusion after hemorrhagic shock and may
Institute of Plant Biochemistry, Cluster of Excellence on Plant Sciences (CEPLAS), Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany 3
Department of Hemostaseology, Düsseldorf University Hospital, Düsseldorf, Germany 4
Plant Metabolism and Metabolomics Laboratory, Cluster of Excellence on Plant Sciences (CEPLAS), Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany 5
Department of Anesthesiology and Intensive Care Medicine, University Hospital Cologne, Cologne, Germany Correspondence Christian Vollmer, Department of Anesthesiology Düsseldorf University Hospital, Düsseldorf, Germany. Email:
[email protected]. de Funding Information This work was supported by departmental funds and in parts by a grant of the German Research Foundation (APMW and TMA: DFG grant EXC 1028).
reduce stress-induced gastric lesions. This study was designed to investigate whether pretreatment with melatonin may influence gastric mucosal microcirculatory perfusion (μflow), oxygenation (μHbO2), or intestinal barrier function during physiological and hemorrhagic conditions in dogs. Methods: In a randomized crossover study, five anesthetized foxhounds received melatonin 100 μg kg−1 or vehicle (ethanol 5%) intravenously in the absence or presence of hemorrhagic shock (60 minutes, −20% blood volume). Systemic hemodynamic variables, gastric mucosal perfusion, and oxygenation were recorded continuously; intestinal barrier function was assessed intermittently via xylose absorption. Results: During hemorrhagic shock, melatonin significantly attenuated the decrease in μflow, compared with vehicle (−19±9 vs −43±10 aU, P
