Metabolic reprogramming induced by ketone bodies diminishes ...

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Sep 29, 2014 - ketone bodies diminishes pancreatic cancer cachexia. Surendra K . Shukla. University of Nebraska Medical Center, [email protected].
University of Nebraska - Lincoln

DigitalCommons@University of Nebraska - Lincoln Robert Powers Publications

Published Research - Department of Chemistry

2014

Correction: Metabolic reprogramming induced by ketone bodies diminishes pancreatic cancer cachexia Surendra K. Shukla University of Nebraska Medical Center, [email protected]

Teklab Gebregiworgis University of Nebraska-Lincoln, [email protected]

Vinee Purohit University of Nebraska Medical Center

Nina V. Chaika University of Nebraska Medical Center, [email protected]

Venugopal Gunda University of Nebraska Medical Center, [email protected] See next page for additional authors

Follow this and additional works at: http://digitalcommons.unl.edu/chemistrypowers Shukla, Surendra K.; Gebregiworgis, Teklab; Purohit, Vinee; Chaika, Nina V.; Gunda, Venugopal; Radhakrishnan, Prakash; Mehla, Kamiya; Pipinos, Iraklis I.; Powers, Robert; Yu, Fang; and Singh, Pankaj K., "Correction: Metabolic reprogramming induced by ketone bodies diminishes pancreatic cancer cachexia" (2014). Robert Powers Publications. Paper 37. http://digitalcommons.unl.edu/chemistrypowers/37

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Authors

Surendra K. Shukla, Teklab Gebregiworgis, Vinee Purohit, Nina V. Chaika, Venugopal Gunda, Prakash Radhakrishnan, Kamiya Mehla, Iraklis I. Pipinos, Robert Powers, Fang Yu, and Pankaj K. Singh

This article is available at DigitalCommons@University of Nebraska - Lincoln: http://digitalcommons.unl.edu/chemistrypowers/37

Shukla et al. Cancer & Metabolism 2014, 2:22 http://www.cancerandmetabolism.com/content/2/1/22

Cancer & Metabolism

CORRECTION

Open Access

Correction: Metabolic reprogramming induced by ketone bodies diminishes pancreatic cancer cachexia Surendra K Shukla1, Teklab Gebregiworgis2, Vinee Purohit1,3, Nina V Chaika1, Venugopal Gunda1, Prakash Radhakrishnan1, Kamiya Mehla1, Iraklis I Pipinos4,5, Robert Powers2, Fang Yu6 and Pankaj K Singh1,3,7,8* Correction After publication of this Research Article [1], we noticed we had included an incorrect image in Figure 1D in the panel for LiAcAc 20 mM. A corrected Figure 1 is included here. Author details 1 The Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 68198, USA. 2Department of Chemistry, University of Nebraska—Lincoln, Lincoln, NE 68588, USA. 3Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198, USA. 4Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, NE 68198, USA. 5Department of Surgery, University of Nebraska Medical Center, Omaha, NE 68198, USA. 6 Department of Biostatistics, University of Nebraska Medical Center, Omaha, NE 68198, USA. 7Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198, USA. 8Department of Genetic Cell Biology and Anatomy, University of Nebraska Medical Center, Omaha, NE 68198, USA. Received: 24 September 2014 Accepted: 24 September 2014 Published: 29 September 2014 Reference 1. Shukla SK, Gebregiworgis T, Purohit V, Chaika NV, Gunda V, Radhakrishnan P, Mehla K, Pipinos II, Powers R, Yu F, Singh PK: Metabolic reprogramming induced by ketone bodies diminishes pancreatic cancer cachexia. Canc Metabol 2014, 2:18. doi:10.1186/2049-3002-2-22 Cite this article as: Shukla et al.: Correction: Metabolic reprogramming induced by ketone bodies diminishes pancreatic cancer cachexia. Cancer & Metabolism 2014 2:22.

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* Correspondence: [email protected] 1 The Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 68198, USA 3 Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198, USA Full list of author information is available at the end of the article

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© 2014 Shukla et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

Shukla et al. Cancer & Metabolism 2014, 2:22 http://www.cancerandmetabolism.com/content/2/1/22

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Figure 1 Ketone bodies inhibit growth and induce apoptosis in pancreatic cancer cell lines. Capan1 (A) and S2-013 (B) cells were treated with different concentrations of sodium-3-hydroxybutyrate (NaHB) and lithium acetoacetate (LiAcAc) for 72 h, and cell viability was determined by MTT assay. Bar represents percent viability under indicated treatments relative to treatment with solvent control. Representative bright-field images of Capan1 (C) and S2-013 (D) cells under treatment with 10- and 20-mM concentrations of NaHB and LiAcAc for 72 h. (E) Multiple pancreatic cancer cell lines were treated with 10- and 20-mM concentrations of NaHB and LiAcAc for 72 h, and relative cell viability determined by MTT assay is plotted in the bar charts. (F) Capan1 and S2-013 cells treated with 10- and 20-mM concentrations of sodium-3-hydroxybutyrate and lithium acetoacetate for 48 h and the relative caspase 3/7 activity are plotted. Values represented are mean ± SEM. *P